ETIOLOGIC FACTORS FOR PREGNANCY-INDUCED HYPERTENSION

妊娠高血压的病因

• 批准号: 2403471
• 负责人: AUDREY FRIEDA SAFTLAS
• 金额: $ 9.8万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2403471
• 关键词: alcoholic beverage consumption; behavioral /social science research tag; cardiovascular disorder epidemiology; diet; disease /disorder proneness /risk; employment /unemployment; female; gestational age; human subject; leisure; longitudinal human study; nutrition related tag; occupational hazard; pathologic process; preeclampsia; prenatal care

DESCRIPTION: (Adapted from Investigator's Abstract) The proposed research is designed to assess the impact of dietary behaviors and activity-related variables on the risk of pregnancy-induced hypertension in a cohort of pregnant women. Only a handful of studies to date have evaluated such associations. Identification of risk factors for pregnancy-induced hypertension (PIH) has assumed even greater importance in the 1990s in light of recent evidence that calcium supplementation and aspirin use during pregnancy may reduce the risk of these conditions. In regard to the outcomes of preeclampsia and gestational hypertension, this research will examine the following: 1) whether caffeine intake is a positive risk factor; 2) whether alcoholic beverage consumption during pregnancy influences risk; 3) whether employment status and occupational factors such as organic solvent exposure increase risk; and 4) whether leisure time physical activity during pregnancy confers protection. Dose-response relationships and risks associated with early and late pregnancy exposures will also be examined. Data for this research come form the Yale Health in Pregnancy Study (1988-1992), a longitudinal epidemiological study of pregnancy outcomes among 2967 pregnant women who received private prenatal care from one of 13 practices in the New Haven area. All women were personally interviewed before 16 weeks gestation, on one to three other occasions during pregnancy, and within days of delivery regarding the factors targeted for analysis. The cohort to be analyzed for the proposed research will be restricted to women who had a live or still- birth after 20 weeks gestation (n=2657). Because the original study was not designed to evaluate PIH as a primary outcome of interest, the principal investigator will review the prenatal and delivery charts of all women who had any mention of hypertension on their charts (N=382) in order to diagnose preeclampsia and gestational hypertension using standardized case definitions. Preeclampsia is defined as hypertension in pregnancy diagnosed after 20 weeks gestation in the presence of proteinuria, and/or edema, and/or a five pound weight gain in one week. Gestational hypertension is hypertension in pregnancy diagnosed after 20 weeks gestation in the absence of proteinuria, edema, and a five pound weight gain in one week. This research will employ standard epidemiologic analytic techniques, including logistic regression analysis, to evaluate exposure/disease associations while controlling simultaneously for the potential effects of interaction and confounding.

描述：（根据调查员的摘要进行了改编）提议 研究旨在评估饮食行为和 与活动相关的变量有关妊娠引起的高血压的风险 在一群孕妇中。迄今为止只有少数研究 评估了此类关联。确定风险因素 怀孕引起的高血压（PIH）已假定更重要 在1990年代，鉴于最近补充钙的证据 怀孕期间使用阿司匹林可能会降低这些风险 状况。关于先兆子痫和妊娠的结果 高血压，这项研究将检查以下：1）是否是否 咖啡因摄入量是一个积极的危险因素。 2）是否酒精饮料 怀孕期间的消费会影响风险； 3）是否就业 状态和职业因素，例如有机溶剂暴露 增加风险； 4）是否在休闲时间进行体育锻炼 怀孕赋予保护。剂量反应关系和风险 与早期和晚期妊娠暴露有关也将是 检查。这项研究的数据构成了耶鲁大学怀孕的健康 研究（1988-1992），一项怀孕的纵向流行病学研究 2967名接受私人产前护理的孕妇的成果 从纽黑文地区的13种实践之一中。所有妇女都是 在妊娠16周之前亲自接受采访，另外一到三个 怀孕期间以及分娩的几天之内 针对分析的因素。要分析的队列 拟议的研究将仅限于现场直播或仍在的妇女 妊娠20周后出生（n = 2657）。因为最初的研究是 并非旨在评估PIH作为感兴趣的主要结果，而是 首席调查员将审查产前和递送图表 所有在图表上提到高血压的女性（n = 382） 为了使用先兆子痫和妊娠高血压诊断 标准化案例定义。子痫前期定义为高血压 在妊娠20周后妊娠妊娠的怀孕中 蛋白尿和/或水肿，和/或一周内体重增加了五磅。 妊娠高血压是在诊断20后诊断出的妊娠高血压 在没有蛋白尿，水肿和五磅的情况下进行妊娠周 体重增加一周。这项研究将采用标准 流行病学分析技术，包括逻辑回归 分析，在控制同时评估暴露/疾病关联 同时，相互作用和混淆的潜在影响。