ETIOLOGIC FACTORS FOR PREGNANCY-INDUCED HYPERTENSION

妊娠高血压的病因

• 批准号: 2403471
• 负责人: AUDREY FRIEDA SAFTLAS
• 金额: $ 9.8万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2403471
• 关键词: alcoholic beverage consumption; behavioral /social science research tag; cardiovascular disorder epidemiology; diet; disease /disorder proneness /risk; employment /unemployment; female; gestational age; human subject; leisure; longitudinal human study; nutrition related tag; occupational hazard; pathologic process; preeclampsia; prenatal care

DESCRIPTION: (Adapted from Investigator's Abstract) The proposed research is designed to assess the impact of dietary behaviors and activity-related variables on the risk of pregnancy-induced hypertension in a cohort of pregnant women. Only a handful of studies to date have evaluated such associations. Identification of risk factors for pregnancy-induced hypertension (PIH) has assumed even greater importance in the 1990s in light of recent evidence that calcium supplementation and aspirin use during pregnancy may reduce the risk of these conditions. In regard to the outcomes of preeclampsia and gestational hypertension, this research will examine the following: 1) whether caffeine intake is a positive risk factor; 2) whether alcoholic beverage consumption during pregnancy influences risk; 3) whether employment status and occupational factors such as organic solvent exposure increase risk; and 4) whether leisure time physical activity during pregnancy confers protection. Dose-response relationships and risks associated with early and late pregnancy exposures will also be examined. Data for this research come form the Yale Health in Pregnancy Study (1988-1992), a longitudinal epidemiological study of pregnancy outcomes among 2967 pregnant women who received private prenatal care from one of 13 practices in the New Haven area. All women were personally interviewed before 16 weeks gestation, on one to three other occasions during pregnancy, and within days of delivery regarding the factors targeted for analysis. The cohort to be analyzed for the proposed research will be restricted to women who had a live or still- birth after 20 weeks gestation (n=2657). Because the original study was not designed to evaluate PIH as a primary outcome of interest, the principal investigator will review the prenatal and delivery charts of all women who had any mention of hypertension on their charts (N=382) in order to diagnose preeclampsia and gestational hypertension using standardized case definitions. Preeclampsia is defined as hypertension in pregnancy diagnosed after 20 weeks gestation in the presence of proteinuria, and/or edema, and/or a five pound weight gain in one week. Gestational hypertension is hypertension in pregnancy diagnosed after 20 weeks gestation in the absence of proteinuria, edema, and a five pound weight gain in one week. This research will employ standard epidemiologic analytic techniques, including logistic regression analysis, to evaluate exposure/disease associations while controlling simultaneously for the potential effects of interaction and confounding.

描述：（改编自研究者摘要）提议的 研究旨在评估饮食行为的影响 与妊娠高血压风险有关的活动相关变量 在一群孕妇中。迄今为止只有少数研究表明 对此类协会进行了评估。识别风险因素 妊娠高血压综合征 (PIH) 变得更加重要 在 20 世纪 90 年代，根据最近的证据表明，钙补充剂 怀孕期间使用阿司匹林可能会降低这些风险 状况。关于先兆子痫和妊娠的结果 高血压，本研究将检查以下内容：1）是否 咖啡因摄入是一个积极的危险因素； 2）是否含酒精饮料 怀孕期间的消费会影响风险； 3）是否就业 状况和职业因素，例如有机溶剂接触 增加风险； 4) 闲暇时间是否进行体力活动 怀孕提供保护。剂量反应关系和风险 与怀孕早期和晚期暴露也有关 检查了。这项研究的数据来自耶鲁大学妊娠健康中心 研究（1988-1992），一项妊娠纵向流行病学研究 2967 名接受私人产前护理的孕妇的结果 来自纽黑文地区 13 个诊所之一。所有的女人都是 怀孕 16 周前进行了个人访谈，针对其他一到三项内容进行了访谈 怀孕期间以及分娩后几天内的情况 分析的目标因素。要分析的队列 拟议的研究将仅限于那些活着或仍然活着的女性 妊娠 20 周后出生 (n=2657)。因为最初的研究是 并非旨在将 PIH 作为主要关注结果进行评估， 主要研究者将审查产前和分娩图表 所有在图表上提及高血压的女性 (N=382) 为了诊断先兆子痫和妊娠高血压，使用 标准化案例定义。先兆子痫被定义为高血压 在妊娠 20 周后诊断的妊娠中，存在以下情况： 蛋白尿，和/或水肿，和/或一周内体重增加五磅。 妊娠高血压是指妊娠20岁以后诊断出的高血压 妊娠周，无蛋白尿、水肿和体重 5 磅的情况 一星期内体重增加。本研究将采用标准 流行病学分析技术，包括逻辑回归 分析，在控制的同时评估暴露/疾病关联 同时考虑相互作用和混杂的潜在影响。