Electrochemical Paper-Based Analytical Devices for Metal Determination

用于金属测定的电化学纸基分析装置

• 批准号: 9409222
• 负责人: Daniel D Miller-Lionberg
• 金额: $ 49.12万
• 依托单位: ACCESS SENSOR TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9409222
• 关键词: Address; Aerosols; Air Pollution; Airborne Particulate Matter; Analytical Chemistry; Anodes; Car Phone; Cardiovascular Diseases; Cathodes; Chemicals; Chemistry; Collection; Communication; Complex Mixtures; Computer software; Consult; Cost Analysis; Data; Devices; Digestion; Elements; Environmental Hazards; Environmental Health; Environmental Monitoring; Epidemiology; Exposure to; Failure; Feedback; Food Analysis; Funding; Generations; Goals; Gold; Health; Heavy Metals; Human Resources; Individual; Industrial Health; Laboratories; Laboratory Study; Link; Lung diseases; Malignant Neoplasms; Measurement; Measures; Metals; Methods; Monitor; National Institute of Environmental Health Sciences; Outcome; Paper; Particulate; Particulate Matter; Performance; Phase; Play; Poison; Population; Predisposition; Process; Publications; Recording of previous events; Reference Standards; Research; Risk; Risk Assessment; Risk Factors; Role; Sampling; Soil; System; Systems Analysis; Techniques; Technology; Testing; Toxic effect; Traction; Transition Elements; Ultrasonics; Vision; Water; air sampling; base; burden of illness; consumer product; cost; design; field study; health disparity; human morbidity; human mortality; improved; innovation; light weight; multidisciplinary; nervous system disorder; new technology; operation; personal exposure monitor; real world application; sensor; success; tool; toxic metal; toxicant

Project Summary The goal of this project is to develop a new sampling and analysis system combining two new technologies. A lightweight ultrasonic sampler will be paired with an electrochemical paper-based analytical device (ePAD) for measurement of metals in airborne particulate matter (PM). Exposure to particulate matter (PM) air pollution ranks as the 5th leading risk factor for human morbidity and mortality worldwide – outpacing the health risks of all other environmental hazards combined. Although PM is a complex mixture of many potentially toxic compounds, the transition and heavy metal content present in PM is thought to play a significant role in toxicity. The disease burden posed by PM is supported by strong epidemiologic links between population exposure and many forms of ill health (e.g., cardiovascular disease, respiratory disease, neurological disorders, and cancer). Despite these scientific links, little is known about individual (i.e., personal) air pollution exposures because existing technologies for assessing personal PM exposure are expensive, burdensome, and complicated. Furthermore, PM sample analysis techniques (especially for transition and heavy metals) are prohibitively high ($100s/sample) and require the use of a centralized laboratory and specialized staff. Access Sensor Technologies has a vision to change this sampling and measurement paradigm by providing low-cost, high- performance tools for quantifying personal exposure to PM toxicants, with an emphasis on metals. The global market for air pollution monitoring exceeds $4B; we seek to leverage this market with a disruptive technology than can revolutionize the state-of-the-art in personal exposure monitoring. During Phase I, the basic analytic chemistry using electrochemical paper-based analytic devices (ePADs) and sample processing componentry for measuring metals were developed and demonstrated. During Phase II, we will develop a product line that includes a wearable (silent, lightweight, compact) air sampler, a streamlined module for chemical analysis, and the software/interface necessary for mobile-phone operation and communications; this ‘total analysis system’ will streamline the process of exposure and risk assessment while dramatically lowering cost. We will validate this system through laboratory and field studies against gold-standard methods. The outcome of this project will be products designed to penetrate research and consulting markets in industrial hygiene and environmental monitoring, with a long-term goal of offering a low-cost consumer product.For this Phase II project, we will 1) Integrate AST's proprietary air sampling technology with a streamlined analytic kit for in-field filter ex-traction and metals analysis 2) Develop an inexpensive and disposable sensor for rapid, simultaneous quantification of multiple met-als from a single air sampling filter and 3) Demonstrate product viability through field testing with early-stage commercial partners. If successful, we will also have product applications beyond particulate air pollution, as the sensor paradigm is amenable for water, soil, and food analyses as well. There is an urgent global need for simpler cheaper analysis of the world around us.

项目概要 该项目的目标是开发一种结合两种新技术的新采样和分析系统。 轻型超声波采样器将与电化学纸质分析装置 (ePAD) 配对，用于 测量空气中颗粒物 (PM) 中的金属 暴露于颗粒物 (PM) 空气污染。 被列为全球人类发病率和死亡率的第五大风险因素——超过了以下健康风险 尽管 PM 是多种潜在有毒物质的复杂混合物。 化合物、PM 中存在的过渡金属和重金属含量被认为在毒性中起着重要作用。 PM 造成的疾病负担得到了人口暴露与 PM 之间强有力的流行病学联系的支持。 许多形式的健康不良（例如心血管疾病、呼吸系统疾病、神经系统疾病和癌症）。 尽管存在这些科学联系，但人们对个人（即个人）空气污染暴露知之甚少，因为 现有的评估个人 PM 暴露的技术昂贵、繁琐且复杂。 此外，PM 样品分析技术（尤其是过渡金属和重金属）的要求过高 （100 美元/样品）并需要使用集中实验室和专业人员。 Technologies 的愿景是通过提供低成本、高性价比来改变这种采样和测量范式。 用于量化个人接触 PM 有毒物质的性能工具，重点是金属。 空气污染监测市场超过 4B 美元；我们寻求通过颠覆性技术来利用这个市场 在第一阶段，基本分析可以彻底改变个人暴露监测的最先进水平。 使用电化学纸基分析装置 (ePAD) 和样品处理组件进行化学分析 在第二阶段，我们将开发用于测量金属的产品线。 包括一个可穿戴（静音、轻便、紧凑）空气采样器、一个用于化学分析的流线型模块，以及 手机操作和通信所需的软件/界面；这个“全面分析系统” 将简化暴露和风险评估的过程，同时大幅降低成本。 该系统是通过针对黄金标准方法的实验室和现场研究得出的。 这些产品旨在渗透工业卫生和咨询领域的研究和咨询市场 环境监测，长期目标是提供低成本的消费产品。对于第二阶段 项目中，我们将 1) 将 AST 专有的空气采样技术与简化的现场分析套件集成 过滤提取和金属分析 2) 开发一种廉价且一次性的传感器，用于快速、同步 对单个空气采样过滤器中的多种金属进行定量，以及 3) 通过以下方式展示产品的可行性 与早期商业合作伙伴进行现场测试，如果成功，我们还将有更多的产品应用。 颗粒空气污染，因为传感器范式也适用于水、土壤和食品分析。 全球迫切需要对我们周围的世界进行更简单、更便宜的分析。