LEAD MOBILIZATION & BONE TURNOVER IN PREGNANCY/LACTATION

领导动员

• 批准号: 2444230
• 负责人: Theresa O. Scholl
• 金额: $ 50.21万
• 依托单位: UNIV OF MED/DENT NJ-SCH OSTEOPATHIC MED
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2444230
• 关键词: adolescence (12-20); blood chemistry; blood pressure; bone metabolism; clinical research; densitometry; developmental nutrition; diet; epidemiology; female; gestational age; human birth weight; human milk; human pregnant subject; human subject; infant human (0-1 year); lactation; lead; longitudinal human study; metal metabolism; mother /infant health care; nutrition related tag; placental transfer; pregnancy

Lead ingestion is considered a major public health problem for infants and children with deleterious effects observed at lower blood lead levels than previously believed. The investigators propose a prospective study of 1000 pregnant women ages 11-30 years, in a triracial community, to examine the role of maternal bone turnover during pregnancy and lactation as a potential source of lead exposure for the fetus and infant (during lactation). The lead sequestered in maternal bone may be mobilized in the process of providing calcium for the fetal and newborn skeleton. This prospective study will allow the investigators to examine lead mobilization from bone turnover in still- growing, adolescent and mature mothers. The specific aims are as follow. 1: To measure maternal blood lead levels and bone (by ultrasound of the os calcis and bone turnover markers) during pregnancy, to correlate these measurements, and to describe them according to characteristics of the mother. 2: To measure maternal blood lead levels and bone (by dual X-ray densitometry, os calcis ultrasound and bone turnover markers) in adolescent and adult women at parturition and at 3, 6, 12 months postpartum to describe the association of these levels by breastfeeding practice and/or maternal growth characteristics. 3: To measure the amount of lead in breast milk and to describe these amount according to maternal bone turnover, growth, chronological and gynecological age, and dietary practices. 4: To measure cord blood lead and whole blood lead in the infant at 6 months postpartum for correlation with maternal lead levels (both blood and breast milk, if applicable), type of infant feeding (breast or bottle feeding), and infant growth characteristics. 5: To relate maternal blood lead levels during pregnancy to maternal blood pressure (during pregnancy), duration of gestation, and infant birthweight. The investigators state that this study has important public health ramifications for understanding if and how accelerated bone turnover in reproduction can accelerate exposure to lead with implications for maternal and infant morbidity.

铅摄入被认为是婴儿的主要公共卫生问题 和在血液铅下观察到有害作用的儿童 水平比以前认为的水平。 调查人员建议 对1000名11-30岁孕妇的前瞻性研究， 三口社区，检查母体骨骼更新的作用 在怀孕和泌乳期间，作为潜在铅暴露的潜在来源 对于胎儿和婴儿（泌乳期间）。 铅隔离 在提供钙的过程中，可能会动员孕产妇骨骼 胎儿和新生儿骨骼。 这项前瞻性研究将允许 研究人员检查静止的骨转换中的铅动员 成长，青少年和成熟的母亲。 具体目的是 跟随。 1：测量母体血铅水平和骨骼（通过超声 OS CALCIS和骨转换标记）在怀孕期间，以相关 这些测量值，并根据特征描述它们 母亲。 2：测量母体血铅水平和骨骼（通过双X射线 光密度法，OS CALCIS超声和骨转换标记） 青少年和成年妇女分娩时以及3、6、12个月 产后通过母乳喂养来描述这些水平的关联 实践和/或产妇生长特征。 3：测量母乳中的铅量并描述这些 根据母体的骨骼更新，生长，年代和 妇科年龄和饮食实践。 4：测量婴儿的脐带血铅和全血铅 产后几个月与孕产妇铅水平相关（两种血液 和母乳，如果适用），是婴儿喂养的类型（乳房或 奶瓶喂养）和婴儿生长特征。 5：将怀孕期间的孕妇血铅水平与母亲联系起来 血压（怀孕期间），妊娠持续时间和婴儿 出生体重。 调查人员指出，这项研究很重要 公共卫生的后果，以理解是否以及如何加速 繁殖中的骨转换可以加速接触 对母亲和婴儿的发病率的影响。