Atlas55+: Creation and Validation of a Reference Brain Functional Atlas for Late Adulthood

Atlas55：成年晚期参考脑功能图谱的创建和验证

基本信息

批准号：
9803960
负责人：
Gaelle Eve Doucet
金额：
$ 8.48万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9803960
关键词：
Adult Age Age-Years Aging Alzheimer&apos s Disease Architecture Atlases Brain Brain Mapping Cognition Cognitive Communities Data Data Set Databases Elderly Event Functional Magnetic Resonance Imaging Functional disorder Impaired cognition Individual Intelligence Lead Life Life Expectancy Link Liquid substance Literature Longevity Maps Measurable Measures Nerve Degeneration Neurodegenerative Disorders Neurosciences Participant Patients Physiological Processes Physiology Population Procedures Public Health Reproducibility Research Research Personnel Rest Sampling Sex Differences Testing United States Universities Validation Validity and Reliability Woman Work age related aged aging brain base brain dysfunction cognitive function cohort connectome healthy aging improved indexing interest lens men mental state mild cognitive impairment network dysfunction neuroimaging older men older women repository sex sexual dimorphism young adult

项目摘要

PROJECT SUMMARY Older individuals represent 15% of the United States population, and this is expected to exceed 20% by 2050. It is therefore critical that we improve our understanding of the physiology of healthy brain aging and the mechanisms that may lead to dysfunction in older people. It is well accepted that the brain is functionally organized into multiple interacting networks. The reliable and reproducible identification of brain functional networks crucially depends on the use of reference functional atlases. Extensive literature has demonstrated that the spatial and functional organization of the brain connectome shows age-related alterations in later life. Yet, there is currently no reference brain functional atlas derived from older adults, and this may undermine the validity and reliability of neuroimaging research in late adulthood. Using pilot data for this application, we show that an age-appropriate brain functional atlas will improve the characterization of the brain functional connectome and its links to cognition in late adulthood. In this context, the aim of this application is to construct and validate the first reference brain functional atlas in healthy adults above the age of 55 years. To achieve this, we will use resting-state functional magnetic resonance imaging (rs-fMRI) from three large, independent and publicly available neuroimaging datasets. Our first aim (Aim 1) is to generate a reference atlas, called “Atlas55+”, using the largest rs-fMRI dataset currently available from the Cambridge Centre for Ageing and Neuroscience (CamCAN) repository (n=326). We will demonstrate the replicability of Atlas55+ in two independent large samples of older healthy participants derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI, n=200) and the Southwest University Adult Lifespan Dataset (n=191) (Aim 2). Because women, on average, have a longer life expectancy than men, we will test whether older women show brain network differences compared to older men. In the event of significant sex differences, we will create the first sex-specific brain functional atlases in older adults (Aim 3). Fourth, we will demonstrate the superiority of network connectivity features derived from Atlas55+ compared to an atlas based on data from younger people in predicting a greater amount of the variance in fluid intelligence in healthy older adults and in Mini Mental Status Examination score in patients with Alzheimer's disease or mild cognitive impairment (Aim 4). The successful completion of this project will provide the first reliable brain functional atlas for adults over the age of 55 years which will be made freely available to other researchers. By mapping the brain functional connectome underlying late adulthood, this work has the potential to elucidate how dysfunction of the brain networks contributes to neurodegenerative conditions.

项目概要老年人占美国人口的 15%，预计到 2050 年这一比例将超过 20%。因此，提高我们对健康大脑衰老的生理学和大脑衰老的生理学的理解至关重要。可能导致老年人功能障碍的机制人们普遍认为大脑功能正常。组织成多个相互作用的网络，可靠且可重复地识别大脑功能。网络关键取决于参考功能图谱的使用。大量文献已经证明。大脑连接组的空间和功能组织在晚年表现出与年龄相关的变化。然而，目前还没有来自老年人的参考脑功能图谱，这可能会破坏我们使用该应用的试点数据展示了成年晚期神经影像学研究的有效性和可靠性。适合年龄的大脑功能图谱将改善大脑功能的表征在这种情况下，该应用程序的目的是构建连接组及其与成年晚期认知的联系。并验证 55 岁以上健康成年人的第一个参考脑功能图谱。为此，我们将使用来自三个大型独立的静息态功能磁共振成像 (rs-fMRI) 我们的第一个目标（目标 1）是生成一个参考图集，称为 “Atlas55+”，使用剑桥老龄化中心目前提供的最大的 rs-fMRI 数据集神经科学 (CamCAN) 存储库 (n=326) 我们将在两个方面演示 Atlas55+ 的可复制性。来自阿尔茨海默病神经影像的老年健康参与者的独立大样本倡议（ADNI，n=200）和西南大学成人寿命数据集（n=191）（目标 2）。女性平均寿命比男性长，我们将测试老年女性是否表现出大脑与年长男性相比的网络差异如果存在显着的性别差异，我们将创建第一个。第四，我们将证明老年人性别特异性大脑功能图谱的优越性。与基于年轻人数据的地图集相比，源自 Atlas55+ 的网络连接功能预测健康老年人和迷你智力的更大程度的流体智力差异阿尔茨海默病或轻度认知障碍患者的状态检查评分（目标 4）。该项目的成功完成将为10岁以上成年人提供第一个可靠的脑功能图谱 55 年，通过绘制大脑功能连接组图，将免费提供给其他研究人员。这项工作有可能阐明成年晚期的大脑网络功能障碍是如何发生的导致神经退行性疾病。