SMOOTH PURSUIT IN ACUTE AND RECOVERING CEREBRAL INJURY

急性脑损伤和康复过程中的顺利追踪

• 批准号: 2444359
• 负责人: MARK J MORROW
• 金额: $ 8.56万
• 依托单位: OLIVE VIEW-UCLA EDUCATION AND RES INST
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2444359
• 关键词: brain injury; cerebral dominance; human subject; infarct; smooth pursuit eye movement; stroke

We propose to study smooth pursuit eye movements in a selected group of patients who have suffered unilateral cerebral infarction. The smooth pursuit system provides a quantifiable model of sensorimotor interaction that incorporates cortical mechanisms for visual motion processing, attention and ocular motor control. Patterns of defective smooth pursuit resulting from focal brain damage reflect the asymmetrical organization of cerebral hemispheric smooth pursuit pathways according to the retinal hemifield and direction of target motion and the gaze field in which eye motion takes place. We will measure horizontal and vertical eye movements with magnetic search coil oculography, using step-ramp and sinusoidal stimuli to identify retinotopic, directional and craniotopic asymmetries of smooth pursuit in patients. Our testing paradigms will explore the physiological bases of directional and craniotopic pursuit deficits. Mathematical modeling of results will be used to describe the operations taking place in cerebral cortex. Pursuit impairment in patients will be correlated with the anatomy of cerebral damage as demonstrated by neuroimaging procedures, to refine localization of cortical regions that participate in smooth pursuit control in humans. In monkeys, significant recovery of smooth pursuit impairment has been documented after cerebral cortical injury. Both local and remote neural plasticity probably facilitate this adaptation. We will compare results, of ocular motor testing done in patients within the first week after cerebral infarction to testing done after four to six months of recovery. This analysis will provide quantitative assessment of the dysfunction caused by focal neural damage in humans and of the degree to which the impairment can be compensated. Comparison of the nature and extent of recovery to the type of pursuit deficit and to the anatomy of the cerebral damage will help characterize the adaptive mechanisms used by the smooth pursuit system.

我们建议在选定的一组中研究平稳的追捕眼动。 患有单侧脑梗塞的患者。光滑 追踪系统提供了可量化的感觉运动相互作用的模型 结合了视觉运动处理的皮质机制， 注意力和眼部运动控制。缺陷平稳追捕模式 局灶性脑损伤导致的反映了不对称的组织 根据视网膜 半运动和目标运动的方向和眼睛的凝视场 运动发生。我们将测量水平和垂直眼动 使用磁性搜索线圈眼镜摄影，使用阶梯型或 刺激以识别视网膜，定向和颅骨不对称 患者的平稳追求。我们的测试范例将探索 定向和颅骨追求缺陷的生理基础。 结果的数学建模将用于描述操作 发生在脑皮质中。患者的追求障碍将是 与大脑损伤的解剖结构相关，如 神经影像学程序，以完善皮质区域的定位 参加人类的平稳追求控制。 在猴子中，平稳追求障碍的重大恢复已经 脑皮质损伤后记录。局部和远程神经 可塑性可能有助于这种适应。我们将比较结果 在后的第一周内进行的眼运动测试 恢复四到六个月后进行的测试脑梗塞。 该分析将提供功能障碍的定量评估 由人类的局灶性神经损害以及 损害可以得到补偿。比较性质和范围 恢复追求不足的类型和大脑的解剖结构 损坏将有助于表征光滑使用的自适应机制 追求系统。