Early Life Exposures and Subsequent Cancer Risk

生命早期的暴露和随后的癌症风险

• 批准号: 10918982
• 负责人: Gretchen Gierach
• 金额: $ 102.87万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10918982
• 关键词: AFP gene; Adult; Adult Children; Androstenedione; Animal Model; Behavioral; Biological Assay; Birth; Birth Weight; Blood specimen; Body of uterus; Boston; Breast Cancer Risk Factor; Categories; China; Cohort Studies; Collaborations; Collection; Contractor; Data; Daughter; Dehydroepiandrosterone Sulfate; Diethylstilbestrol; Disease; Electronics; Estradiol; Estriol; Estrogens; Estrone; Europe; Exposure to; Female; Functional disorder; Gestational Age; Health Sciences; Hormones; Immune system; Insulin-Like Growth Factor Binding Protein 3; Label; Laboratories; Link; Louisiana; Malignant Neoplasms; Maternal Age; Medical Records; Medical center; Mothers; National Institute of Child Health and Human Development; Pathology Report; Perinatal; Pharmaceutical Preparations; Phase; Placenta; Pre-Eclampsia; Pregnancy; Pregnant Women; Premature Birth; Preneoplastic Conditions; Prevention; Progesterone; Prolactin; Questionnaires; Reporting; Son; Spontaneous abortion; Standardization; Testosterone; Twin Multiple Birth; Umbilical Cord Blood; Umbilical cord structure; Universities; Uterine Diseases; Work; cancer risk; cohort; dehydroepiandrosterone; early life exposure; follow-up; high risk; in utero; male; medical schools; member; neoplasm registry; offspring; prenatal exposure; prostate cancer risk; reproductive; vaginal clear cell adenocarcinoma

00020 - Diethylstilbestrol (DES), a drug first synthesized in 1938, was administered to several million pregnant women in the U.S. and Europe for the prevention of spontaneous abortion and premature delivery. In 1971, Herbst reported a strong association between DES use in pregnancy and the occurrence of vaginal clear cell adenocarcinoma (CCA) in exposed female offspring. Animal models have demonstrated a range of DES effects on offspring exposed in utero, including reproductive dysfunction, immune system changes, behavioral and sexual abnormalities, and increases in various reproductive cancer in males and females. NCI, in collaboration with five field centers, reassembled previously studied cohorts of DES-exposed and unexposed mothers, daughters and sons, and identified subjects with documented exposure status who had not been studied previously, through familial links within the cohorts. Standardized baseline questionnaires were mailed to cohort members to ascertain the risk of cancer and other disorders. Pathology reports were collected for reported cancers and preneoplastic conditions. Theree separate phases of follow-up have been conducted. The purpose of this study is to continue the follow-up, by means of mailed questionnaires and medical record collection, which was begun during the the first phase of the study. Concern has arisen that DES-exposed daughters may be at higher risk of breast cancer. Exposure to high levels of endogenous estrogen in utero has been hypothesized to increase the risk of breast cancer and DESis a potent estrogen. Cacner risk in the sons will also continure to be assessed, especailly for increased risks of prostate cancer. since the offspring who were exposed to DES in utero are currently reaching their late forties, when cancer rates begin to rise, it is important to continue the follow-up of these cohorts to determine if there are long-term increases in cancer risk. 10039 - The proposed study involves collecting maternal and cord blood samples from monochorionic twin, dichorionic twin and singleton pregnancies of similar gestational age to quantify differences in concentrations of several hormones and other pregnancy products including estriol, estradiol, estrone, testosterone, androstenedione, dehydroepiandrosterone (DHEA), DHEA-sulfate, progesterone, AFP, prolactin, IGF and IGF-binding protein 3. Data from medical records and pathology reports will be abstracted to provide information on the mother, baby, pregnancy and placenta. The work will be done at Dartmouth Hitchcock Medical Center, Dartmouth Medical School. Blood samples labeled with a unique ID number only will be sent to Bioreliance, NCI's contractor, for preperation and shipment to the laboratory that will perform the hormone assays. NCI will receive the abstracted data in electronic form. no personal identifying information will be received by NCI or its contractor. The study has been approved by Dartmouth Medical School. 10041 - The Norwegian birth and cancer registries will be used to investigate the association of several pregnancy and perinatal factors and risk of cancer in adult offspring. 10032 - Collaboration with NICHD on a study of preeclampsia conducted at Louisiana State University Health Sciences Center. Blood samples are being collected from mothers and from umbilical cords with and without preeclampsia. The relationship of pregnancy hormone levels and preeclampsia will be analyzed. 01132 - In this study using data from a cohort study of preeclamptic and uncomplicated pregnancies at the University of Pittsburgh, we are analyzing maternal and cord blood samples from preeclamptic and normal pregnancies of similar gestational age to quantify differences in levels of various hormones. We will evaluate associations of several maternal, perinatal and pregnancy factors, such as maternal age and birth weight, with hormone levels in normal pregnancies. In addition, we will determine how well maternal levels represent levels in cord blood. 00043 - Umbilical cord blood samples were collected from 75 pregnancies in Boston, MA and 175 in Shanghai, China. Pregnancy hormone concentrations will be determined and correlated with putative breast cancer risk factors.

00020 -Diethylstilbestrol（DES）是1938年首次合成的药物，在美国和欧洲为预防自发流产和早产提供了数百万孕妇。 1971年，赫布斯特（Herbst）报道了在妊娠中使用的DES使用与暴露的雌性后代中阴道透明细胞腺癌（CCA）的发生之间的密切关联。动物模型已经证明了对子宫内暴露的后代的一系列影响，包括生殖功能障碍，免疫系统变化，行为和性异常，以及男性和女性的各种生殖癌的增加。 NCI与五个野外中心合作，重新组装了先前研究的人群和未暴露的母亲，女儿和儿子，并确定了以前没有研究过的暴露状态的受试者，这些受试者是通过人群中的家族链接进行的。标准化的基线问卷已邮寄给队列成员，以确定癌症和其他疾病的风险。收集病理报告的癌症和肿瘤性疾病。进行了随访的单独阶段。这项研究的目的是通过邮寄的问卷和病历收集来继续进行后续行动，这是在研究的第一阶段开始的。人们担心暴露的女儿可能患乳腺癌的风险更高。假设在子宫内暴露于高水平的内源性雌激素，以增加患乳腺癌的风险和有效的雌激素。儿子的卡斯纳风险也将继续进行评估，特别是增加了前列腺癌风险。由于目前在子宫内接触过DES的后代已经到了四十多岁，因此癌症发生率开始上升，重要的是要继续对这些同类群体进行随访，以确定癌症风险是否长期增加。 10039 - The proposed study involves collecting maternal and cord blood samples from monochorionic twin, dichorionic twin and singleton pregnancies of similar gestational age to quantify differences in concentrations of several hormones and other pregnancy products including estriol, estradiol, estrone, testosterone, androstenedione, dehydroepiandrosterone (DHEA), DHEA-sulfate, progesterone, AFP，催乳素，IGF和IGF结合蛋白3。这项工作将在达特茅斯医学院的达特茅斯希区柯克医学中心完成。只有唯一ID编号的血液样本将被发送给NCI承包商Biorliance，以进行预先处理和运送将执行激素测定法的实验室。 NCI将以电子形式接收抽象的数据。 NCI或其承包商不会收到个人身份信息。该研究已获得达特茅斯医学院的批准。 10041年 - 挪威出生和癌症登记处将用于调查成人后代的几种怀孕和围产期因素以及癌症风险的关联。 10032-与NICHD合作就在路易斯安那州立大学健康科学中心进行的先兆子痫进行研究。从母亲那里收集血液样本，并从有或没有先兆子痫的脐带中收集血液样本。将分析怀孕激素水平和先兆子痫的关系。 01132-在这项研究中，我们使用匹兹堡大学的先兆疗法和简单怀孕的队列研究数据，我们正在分析来自相似妊娠年龄的前疗和正常妊娠的母体和脐带血样本，以量化各种激素水平的差异。我们将评估几种产妇，围产期和妊娠因素（例如产妇年龄和出生体重）的关联，正常妊娠中的激素水平。此外，我们将确定孕产妇水平在脐带血中的水平。 00043-从马萨诸塞州波士顿的75例怀孕和中国上海的175例收集脐带血样本。怀孕激素浓度将确定并与推定的乳腺癌危险因素相关。

项目成果

A migrant study of pubertal timing and tempo in British-Bangladeshi girls at varying risk for breast cancer.

• DOI: 10.1186/s13058-014-0469-8
• 发表时间: 2014-11-15
• 期刊: Breast cancer research : BCR
• 作者: Houghton LC;Cooper GD;Bentley GR;Booth M;Chowdhury OA;Troisi R;Ziegler RG;Hoover RN;Katki HA
• 通讯作者: Katki HA

Associations of pregnancy characteristics with maternal and cord steroid hormones, angiogenic factors, and insulin-like growth factor axis.

• DOI: 10.1007/s10552-011-9835-3
• 发表时间: 2011-11
• 期刊: CANCER CAUSES & CONTROL
• 影响因子: 2.3
• 作者: Faupel-Badger, Jessica M.;Wang, Yuping;Karumanchi, S. Ananth;Stanczyk, Frank;Pollak, Michael;McElrath, Thomas;Hoover, Robert N.;Troisi, Rebecca
• 通讯作者: Troisi, Rebecca

Pregnancy weight gain is not associated with maternal or mixed umbilical cord estrogen and androgen concentrations.

• DOI: 10.1007/s10552-008-9235-5
• 发表时间: 2009-03
• 期刊: CANCER CAUSES & CONTROL
• 影响因子: 2.3
• 作者: Faupel-Badger, Jessica M.;Hoover, Robert N.;Potischman, Nancy;Roberts, James M.;Troisi, Rebecca
• 通讯作者: Troisi, Rebecca

Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies.

• DOI: 10.1016/j.ajog.2008.06.030
• 发表时间: 2008-12
• 期刊: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
• 影响因子: 9.8
• 作者: Troisi, Rebecca;Braekke, Kristin;Harsem, Nina Kittelsen;Hyer, Marianne;Hoover, Robert N.;Staff, Anne Cathrine
• 通讯作者: Staff, Anne Cathrine

Perinatal risk factors for childhood testicular germ-cell cancer: a Nordic population-based study.

儿童睾丸生殖细胞癌的围产期危险因素：一项基于北欧人群的研究。

• DOI: 10.1016/j.canep.2011.07.003
• 发表时间: 2011
• 期刊: Cancer epidemiology
• 影响因子: 2.6
• 作者: Stephansson,Olof;Wahnström,Caroline;Pettersson,Andreas;Sørensen,HenrikToft;Tretli,Steinar;Gissler,Mika;Troisi,Rebecca;Akre,Olof;Grotmol,Tom
• 通讯作者: Grotmol,Tom