Advancing primate models of human auditory cognitive control
推进人类听觉认知控制的灵长类动物模型
基本信息
- 批准号:10564530
- 负责人:
- 金额:$ 45.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-01-01 至 2027-12-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAreaAttentionAuditoryBehavioral AssayBehavioral ModelBiomedical ResearchBrainCognitiveCommunicationCommunication impairmentComparative StudyComplementDataDecision MakingDevelopmentDiagnosticDiagnostic testsDissociationDorsalFoundationsFutureGoalsHearing TestsHumanIndividualInstructionInterventionIntervention StudiesLanguageLinkMacaca mulattaMaintenanceMemoryMissionModalityModelingMonkeysNational Institute on Deafness and Other Communication DisordersOutcomeOutcomes ResearchPathway interactionsPongo pygmaeusPrimatesProcessPublic HealthReportingResearchResearch PersonnelRoleShort-Term MemorySpeechStreamSystemTechniquesTestingTrainingVisualWorkattentional controlattenuationauditory pathwaycognitive abilitycognitive capacitycognitive controlcognitive loadcognitive processcognitive systemdirected forgettingexperimental studyflexibilityhuman modelinnovationlanguage impairmentmemory processneuralneuromechanismnonhuman primatenovelskillsspeech processing
项目摘要
Abstract
The development of more powerful primate models of auditory cognitive control is critical for
advancing understanding of the cognitive and neural systems underlying the capacity for human
communication. Valid models depend on identification of which aspects of these systems are
present in monkeys. The long-term goal of this work is to better understand the relations
between auditory cognitive control in humans and primates, enhancing the utility of primate
models for research on auditory-communicative disorders. The overall objective of this
application is to identify some aspects of auditory cognitive control in humans that can be
modeled in primates. The central working hypothesis is that the same experimental techniques
used to establish visual cognitive control can also elucidate components of auditory cognitive
control. The rationale is that valid behavioral models of auditory cognitive control in primates are
foundational for studies of the relevant neural systems, and ultimately for developing and testing
novel treatments for individuals with communication disorders. The central hypothesis will be
tested by accomplishing three specific aims: (1) Use tests that are diagnostic of working
memory to determine which components of human auditory working memory can be modeled in
rhesus monkeys, (2) Assess cognitive control of auditory attention and decision-making in
monkeys, and (3) Evaluate a putative neural substrate of auditory cognitive control using
comparative studies across humans, orangutans, and monkeys. For the first aim, whether
monkeys engage in active maintenance of information in auditory working memory will be tested
using competing cognitive load and directed forgetting manipulations in auditory memory tests.
For the second aim, control of auditory attention will be evaluated using tasks that require
flexibly focusing auditory attention and filtering auditory distractors. Cognitive control of
decision-making will be evaluated using tests of adaptive information-seeking. For the third aim,
auditory cognitive abilities will be compared across monkeys, orangutans, and humans to
evaluate the putative correlation between these skills and expansion of the dorsal auditory
pathway. The proposed research is innovative because it uses novel tests of auditory working
memory, attentional control, and adaptive decision-making that specifically dissociate these
processes from non-controlled, passive, or automatic mechanisms. The work also achieves a
systematic comparison of auditory memory across primates using equivalent tests. The
proposed research is significant because it is expected to provide a robust foundation for future
biomedical research on auditory-communicative deficits using proven primate models.
抽象的
开发更强大的听觉认知控制灵长类动物模型对于
增进对人类能力背后的认知和神经系统的理解
沟通。有效的模型取决于对这些系统的哪些方面的识别
存在于猴子体内。这项工作的长期目标是更好地理解这些关系
人类和灵长类动物的听觉认知控制之间的关系,增强灵长类动物的效用
听觉交流障碍研究模型。本次活动的总体目标
应用程序是确定人类听觉认知控制的某些方面,这些方面可以
以灵长类动物为模型。中心工作假设是相同的实验技术
用于建立视觉认知控制也可以阐明听觉认知的组成部分
控制。基本原理是灵长类动物听觉认知控制的有效行为模型是
为相关神经系统的研究以及最终的开发和测试奠定基础
针对患有沟通障碍的个体的新疗法。中心假设将是
通过实现三个具体目标进行测试:(1)使用诊断工作的测试
记忆以确定人类听觉工作记忆的哪些组成部分可以建模
恒河猴,(2) 评估听觉注意力和决策的认知控制
猴子,以及(3)使用评估听觉认知控制的假定神经基础
人类、猩猩和猴子的比较研究。对于第一个目标,是否
猴子对听觉工作记忆中信息的主动维护将受到测试
在听觉记忆测试中使用竞争性认知负荷和定向遗忘操作。
对于第二个目标,将使用需要的任务来评估听觉注意力的控制
灵活地集中听觉注意力并过滤听觉干扰。认知控制
将使用适应性信息寻求测试来评估决策。为了第三个目标,
将比较猴子、猩猩和人类的听觉认知能力
评估这些技能与背听觉扩展之间的假定相关性
途径。拟议的研究具有创新性,因为它使用了新颖的听觉工作测试
记忆、注意力控制和适应性决策专门将这些
来自非受控、被动或自动机制的过程。该工作还取得了
使用等效测试对灵长类动物的听觉记忆进行系统比较。这
拟议的研究意义重大,因为预计它将为未来提供坚实的基础
使用经过验证的灵长类动物模型对听觉交流缺陷进行生物医学研究。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT R HAMPTON其他文献
ROBERT R HAMPTON的其他文献
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{{ truncateString('ROBERT R HAMPTON', 18)}}的其他基金
Memory Monitoring and Declarative Memory: Behavior and Brain
记忆监控和陈述性记忆:行为和大脑
- 批准号:
8089362 - 财政年份:2008
- 资助金额:
$ 45.14万 - 项目类别:
Memory Monitoring and Declarative Memory: Behavior and Brain
记忆监控和陈述性记忆:行为和大脑
- 批准号:
8279096 - 财政年份:2008
- 资助金额:
$ 45.14万 - 项目类别:
Memory Monitoring and Declarative Memory: Behavior and Brain
记忆监控和陈述性记忆:行为和大脑
- 批准号:
7905782 - 财政年份:2008
- 资助金额:
$ 45.14万 - 项目类别:
Memory Monitoring and Declarative Memory: Behavior and Brain
记忆监控和陈述性记忆:行为和大脑
- 批准号:
7652492 - 财政年份:2008
- 资助金额:
$ 45.14万 - 项目类别:
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