Advancing primate models of human auditory cognitive control

推进人类听觉认知控制的灵长类动物模型

• 批准号: 10564530
• 负责人: ROBERT R HAMPTON
• 金额: $ 45.14万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10564530
• 关键词: Address; Area; Attention; Auditory; Behavioral Assay; Behavioral Model; Biomedical Research; Brain; Cognitive; Communication; Communication impairment; Comparative Study; Complement; Data; Decision Making; Development; Diagnostic; Diagnostic tests; Dissociation; Dorsal; Foundations; Future; Goals; Hearing Tests; Human; Individual; Instruction; Intervention; Intervention Studies; Language; Link; Macaca mulatta; Maintenance; Memory; Mission; Modality; Modeling; Monkeys; National Institute on Deafness and Other Communication Disorders; Outcome; Outcomes Research; Pathway interactions; Pongo pygmaeus; Primates; Process; Public Health; Reporting; Research; Research Personnel; Role; Short-Term Memory; Speech; Stream; System; Techniques; Testing; Training; Visual; Work; attentional control; attenuation; auditory pathway; cognitive ability; cognitive capacity; cognitive control; cognitive load; cognitive process; cognitive system; directed forgetting; experimental study; flexibility; human model; innovation; language impairment; memory process; neural; neuromechanism; nonhuman primate; novel; skills; speech processing

Abstract The development of more powerful primate models of auditory cognitive control is critical for advancing understanding of the cognitive and neural systems underlying the capacity for human communication. Valid models depend on identification of which aspects of these systems are present in monkeys. The long-term goal of this work is to better understand the relations between auditory cognitive control in humans and primates, enhancing the utility of primate models for research on auditory-communicative disorders. The overall objective of this application is to identify some aspects of auditory cognitive control in humans that can be modeled in primates. The central working hypothesis is that the same experimental techniques used to establish visual cognitive control can also elucidate components of auditory cognitive control. The rationale is that valid behavioral models of auditory cognitive control in primates are foundational for studies of the relevant neural systems, and ultimately for developing and testing novel treatments for individuals with communication disorders. The central hypothesis will be tested by accomplishing three specific aims: (1) Use tests that are diagnostic of working memory to determine which components of human auditory working memory can be modeled in rhesus monkeys, (2) Assess cognitive control of auditory attention and decision-making in monkeys, and (3) Evaluate a putative neural substrate of auditory cognitive control using comparative studies across humans, orangutans, and monkeys. For the first aim, whether monkeys engage in active maintenance of information in auditory working memory will be tested using competing cognitive load and directed forgetting manipulations in auditory memory tests. For the second aim, control of auditory attention will be evaluated using tasks that require flexibly focusing auditory attention and filtering auditory distractors. Cognitive control of decision-making will be evaluated using tests of adaptive information-seeking. For the third aim, auditory cognitive abilities will be compared across monkeys, orangutans, and humans to evaluate the putative correlation between these skills and expansion of the dorsal auditory pathway. The proposed research is innovative because it uses novel tests of auditory working memory, attentional control, and adaptive decision-making that specifically dissociate these processes from non-controlled, passive, or automatic mechanisms. The work also achieves a systematic comparison of auditory memory across primates using equivalent tests. The proposed research is significant because it is expected to provide a robust foundation for future biomedical research on auditory-communicative deficits using proven primate models.

抽象的 听觉认知控制更强大的灵长类动物模型的发展对于 促进对人类能力背后的认知和神经系统的理解 沟通。有效模型取决于确定这些系统的哪些方面 在猴子中存在。这项工作的长期目标是更好地了解关系 在人类和灵长类动物的听觉认知控制之间，增强灵长类动物的效用 研究听觉传说疾病的研究模型。总体目标 应用是确定人类听觉认知控制的某些方面 在灵长类动物中建模。中心工作假设是相同的实验技术 用于建立视觉认知控制的人还可以阐明听觉认知的组成部分 控制。理由是灵长类动物中听觉认知控制的有效行为模型是 相关神经系统研究的基础，最终用于开发和测试 沟通障碍的人的新型治疗方法。中心假设将是 通过完成三个具体目标测试：（1）使用诊断的测试 记忆以确定可以在 （2）评估听觉关注和决策的认知控制 猴子和（3）使用使用听觉控制的推定神经基板使用 跨人类，猩猩和猴子的比较研究。对于第一个目标，是否 将测试猴子在听觉工作记忆中积极维护信息 使用竞争性的认知负载和在听觉记忆测试中的定向遗忘操作。 对于第二个目标，将使用需要的任务来评估听觉关注的控制 灵活地关注听觉注意力并过滤听觉干扰器。认知控制 将使用自适应信息寻求的测试对决策进行评估。对于第三个目标， 将在猴子，猩猩和人类中比较听觉认知能力 评估这些技能与背部听觉扩展之间的推定相关性 路径。拟议的研究具有创新性，因为它使用了新颖的听觉测试 记忆，注意力控制和自适应决策，专门解离这些 来自非控制，被动或自动机制的过程。这项工作也取得了成就 使用等效测试对灵长类动物的听觉记忆进行系统比较。这 拟议的研究很重要，因为它有望为未来提供强大的基础 使用经过验证的灵长类动物模型对听觉交流缺陷的生物医学研究。