Influence of Vision Impairments on Dementia in Stroke Survivors: A Longitudinal Analysis

视力障碍对中风幸存者痴呆的影响：纵向分析

• 批准号: 10592061
• 负责人: Kimberly Patrice Hreha
• 金额: $ 12.14万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-07 至 2026-04-06
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592061
• 关键词: Address; Advanced Development; Age; Age related macular degeneration; Atherosclerosis Risk in Communities; Award; Career Mobility; Characteristics; Clinic; Clinical; Clinical Research; Clinical assessments; Cognitive; Communities; Community Participation; Complex; Data; Data Set; Dementia; Development; Disease; Early Diagnosis; Educational workshop; Enrollment; Epidemiology; Eye diseases; Funding; Future; Goals; Health; Health Services Research; Impaired cognition; Intervention; Knowledge; Learning; Mediating; Medical center; Mental Depression; Mental Health; Mentors; Mentorship; Methods; Minority Groups; Neurologic; Neuropsychology; Occupational Therapist; Outcome; Persons; Population; Prevalence; Prevention strategy; Productivity; Research; Research Activity; Research Methodology; Research Personnel; Research Proposals; Risk; Services; Statistical Data Interpretation; Stroke; Surveys; Testing; Training; Training Activity; Vision; Visual; Visual impairment; Vulnerable Populations; Work; career development; cohort; dementia risk; depressive symptoms; direct application; experience; functional disability; functional independence; functional status; improved; innovation; insight; leadership development; longitudinal analysis; meetings; novel; physically handicapped; post stroke; post stroke dementia; programs; prospective; psychologic; rehabilitation research; skill acquisition; skills; stroke survivor; symptomatology

PROJECT SUMMARY/ ABSTRACT This is an application for a K01 Mentored Research Scientific Development Award. The goal of the proposed project is to provide the candidate with the advanced skills needed to establish an independent research program examining the visual health needs of stroke survivors also living with dementia. To facilitate this long-term goal, the candidate proposes a comprehensive training plan, combining formal coursework and meetings overseen by her mentors, participation in applied training experiences and involvement in seminars and workshops. Specific training goals include: (1) gain advanced knowledge in the epidemiology and mechanisms of post-stroke dementia, (2) learn neuropsychological and clinical assessment of dementia, (3) acquire skills and training in clinical research methodology and statistical analysis, using both cross sectional and longitudinal data and (4) productively participate in career advancement and leadership development activities. The training plan will be executed in coordination with the set of research activities mentioned above, which are based on preliminary data collected by the applicant. The preliminary data show a lack of research on whether the presence of specific types of vision impairment and ocular deficits increase the risk of post-stroke dementia. The candidate will expand on these findings by using data from the Atherosclerosis Risk in Communities stroke cohort to complete the following aims: (1) characterize the prevalence and outcomes associated with vision impairment(s) among stroke survivors with and without dementia; (2) determine how pre-existing vision impairments impact the development of dementia, among those with stroke; and (3) determine the effect and downstream consequences of post-stroke vision impairment in persons without pre-existing vision impairment. The primary hypotheses include that: (1) the odds of developing dementia are higher for stroke survivors with pre-existing vision impairment, compared to stroke survivors with normal vision; (2) stroke survivors with vision impairment preceding the stroke are more likely to develop dementia earlier, compared to stroke survivors with normal vision; and (3) the impact of post-stroke vision impairment on dementia development is stronger for those with functional impairment, compared to those without functional impairment. The expected findings will provide critical insight into the types of vision impairment and ocular deficits experienced by people with post-stroke dementia, including more information on the significance of distinguishing between pre- and post-stroke visual impairments and the expected differential impact on dementia. Results from this research will be used to develop a subsequent R01 research proposal that will facilitate the candidate’s transition into an independent researcher focused on analysis of existent data and prospective enrollment to optimize the independence and community participation of stroke survivors with vision impairments and dementia.

项目概要/摘要 这是 K01 指导研究科学发展奖的申请 拟议的目标。 项目旨在为候选人提供建立独立研究计划所需的高级技能 检查同时患有痴呆症的中风幸存者的视觉健康需求为了实现这一长期目标， 候选人提出全面的培训计划，结合正式课程和监督会议 通过她的导师，参与应用培训经验并参加研讨会和讲习班。 具体培训目标包括：（1）获得中风后流行病学和机制的高级知识 痴呆症，(2) 学习痴呆症的神经心理学和临床评估，(3) 获得以下方面的技能和培训： 临床研究方法和统计分析，使用横截面和纵向数据以及 (4) 培训计划将有效地参与职业发展和领导力发展活动。 与上述一系列研究活动协调执行，这些活动基于初步 申请人收集的数据初步显示缺乏对是否存在特定情况的研究。 视力障碍和眼部缺陷的类型会增加中风后痴呆的风险。 候选人将利用社区中风中动脉粥样硬化风险的数据来扩展这些发现 队列完成以下目标：（1）描述与视力相关的患病率和结果 患有或不患有痴呆症的中风幸存者的损伤（2）如何确定预先存在的视力； 损伤会影响中风患者痴呆症的发展；(3) 确定影响； 对于没有预先存在视力障碍的人来说，中风后视力障碍的下游后果。 主要假设包括：(1) 患有以下疾病的中风幸存者患痴呆症的几率更高 (2) 中风幸存者有视力 与中风幸存者相比，中风前的损伤更有可能更早患上痴呆症 正常视力；(3) 中风后视力障碍对痴呆症发展的影响更大 与没有功能障碍的人相比，预期的结果将提供。 对中风后患者所经历的视力障碍和眼部缺陷类型的批判性见解 痴呆症，包括有关区分中风前和中风后视觉重要性的更多信息 这项研究的结果将用于开发损伤和对痴呆症的预期差异影响。 随后的 R01 研究计划将有助于候选人转变为独立研究员 专注于分析现有数据和预期入学，以优化独立性和社区 患有视力障碍和痴呆症的中风幸存者的参与。