University of Iowa Institute for Clinical and Translational Science

爱荷华大学临床与转化科学研究所

• 批准号: 10622212
• 负责人: Marlan R Hansen
• 金额: $ 403.08万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10622212
• 关键词: Acceleration; Adoption; Affect; Age; Ally; Automobile Driving; Basic Science; Biomedical Research; Caring; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Community Practice; Computerized Medical Record; Data; Data Collection; Development; Disease Outcome; Diverse Workforce; Education; Environment; Family Physicians; Funding; Genetic; Geography; Goals; Health; Health Personnel; Health system; Healthcare; Healthcare Systems; Home; Human; Human Subject Research; Individual; Informatics; Infrastructure; Institution; Integrated Health Care Systems; Intervention; Iowa; Learning; Life; Link; Longevity; Measurable; Medical Care Team; Mentors; Methods; Mission; Modeling; Outcome; Patient Participation; Patients; Pharmacists; Physicians; Play; Population; Population Heterogeneity; Process; Provider; Research; Research Methodology; Research Personnel; Role; Rural; Rural Community; Rural Population; School Nursing; Science; Scientist; Side; System; Technology; Testing; Time; Training; Translational Research; Translations; Universities; Work; care systems; catalyst; clinical care; clinical implementation; clinical practice; clinical translation; community engagement; community organizations; community setting; data infrastructure; data warehouse; demographics; design; efficacy testing; evidence base; geographic barrier; health care availability; health care delivery; health disparity; implementation science; improved; informatics infrastructure; innovation; interoperability; medical specialties; member; mobile computing; multidisciplinary; new technology; novel; novel strategies; novel therapeutics; population health; practice-based research network; precision medicine; programs; rural area; rural disparities; rural dwellers; rurality; social; stakeholder perspectives; systems research; tool; translational scientist; underserved community; virtual; workforce needs

ABSTRACT The Institute for Clinical and Translational Science (ICTS) at the University of Iowa (UI) has three aims – (1) to promote an innovative, integrated, geographically distributed framework for conducting clinical and translational research, 2) to create new methods and tools that promote research participation, data collection, and interventions that link the clinic to the home and 3) to develop the diverse workforce needed to catalyze innovative science throughout populations. ICTS tackles large problems affecting translational science that require institutional solutions, such as transforming regulatory processes for human subjects research, developing an informatics infrastructure for integrating electronic medical record and other health care data, establishing bi-directional relationships with community organizations, and revitalizing the pipeline of well- trained clinical and translational researchers. Our overarching goal is to accelerate integration of research into clinical partnerships around the state and, through team science, bringing our basic, translational and clinical research workforce together to escalate the pace and breadth of scientific discovery to impact healthcare for the state and beyond. Iowa is a rural state, which brings special health care needs and challenges. We have used these rural considerations as a catalyst for driving our approach to clinical and translational research pushing our teams to develop strategies to engage rural populations of all ages and backgrounds and to create new approaches that overcome the geographic barriers in a rural state. We are capitalizing on our established community practice networks of family physicians, clinics, school nurses and pharmacists. We utilize mobile platforms in novel ways and will test the efficacy of these methods of engagement. As we move research to “IMpact Across Geographies using Innovation, Networks and Engagement- IMAG-INE” we have created methods to capture real-time, real-life data from the home and to correlate this environmentally specific, comprehensive data to human health research and outcomes. The ICTS is engaging with other CTSA hubs and national clinical and translational research systems to empirically test different approaches and to develop the evidence base of proven strategies for accelerating translation that can be more broadly disseminated. Though distance and rurality drive our approaches, the strategies that we develop are simply new and potentially better ways to generate broad representation and improved participation by patients, healthcare teams and academicians. Through our local, state and national collaborations, UI and the ICTS are poised to move clinical and translational discovery rapidly into healthcare practice in a variety of clinical settings.

抽象的 爱荷华大学 (UI) 临床与转化科学研究所 (ICTS) 的三个目标 – (1) 促进创新、综合、地理分布的框架来开展临床和 转化研究，2）创造新的方法和工具来促进研究参与、数据收集， 以及将诊所与家庭联系起来的干预措施，以及 3) 培养促进 ICTS 解决了影响转化科学的重大问题。 需要制度解决方案，例如改变人类受试者研究的监管流程， 开发信息学基础设施以整合电子病历和其他医疗保健数据， 与社区组织建立双向关系，并重振良好的管道 我们的首要目标是加速将研究融入到训练有素的临床和转化研究人员中。 全国范围内的临床合作伙伴关系，并通过团队科学，将我们的基础、转化和临床 研究人员共同提高科学发现的速度和广度，以影响医疗保健 国家及其他地区。 爱荷华州是一个农村州，这给我们带来了特殊的医疗保健需求和挑战。 作为推动我们临床和转化研究方法的催化剂，推动我们的团队 制定战略，让所有年龄和背景的农村人口参与进来，并制定新的方法 我们正在利用我们既定的社区实践克服农村地区的地理障碍。 家庭医生、诊所、学校护士和药剂师网络我们利用移动平台。 当我们将研究转向“影响力”时，我们将测试这些参与方法的有效性。 使用创新、网络和参与的地理区域 - IMAG-INE”我们已经创建了方法 从家里捕获实时、真实的数据，并将这些数据与环境特定的、全面的数据关联起来 ICTS 正在与其他 CTSA 中心和国家合作。 临床和转化研究系统，以经验方式测试不同的方法并开发证据 加速翻译的经过验证的策略的基础，可以通过距离进行更广泛的传播。 乡村推动了我们的方法，我们制定的战略只是新的、可能更好的方法 产生广泛的代表性并提高患者、医疗团队和学者的参与度。 通过我们地方、州和国家的合作，UI 和 ICTS 准备推动临床和 将发现迅速转化为各种临床环境中的医疗保健实践。