Data Management and Statistical Core

数据管理与统计核心

• 批准号: 10620675
• 负责人: Sudeshna Das
• 金额: $ 34.63万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10620675
• 关键词: Acceleration; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Basic Science; Biological Markers; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communication; Communities; Community Outreach; Computer software; Consultations; Data; Data Analyses; Data Set; Databases; Development; Disease; Early identification; Education; Electronic Health Record; Engineering; Ensure; Epidemiology; Future; Genotype; Goals; Heterogeneity; Image; Impaired cognition; Individual; Informatics; Infrastructure; Link; Massachusetts; Measures; Memory; Methodology; Methods; Participant; Publications; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resource Informatics; Resources; Sampling Biases; Science; Scientist; Secure; Selection Bias; Source; Source Code; Standardization; Statistical Methods; Statistical Models; Subjects Selections; System; Terminology; Training; Translational Research; Underrepresented Minority; Videotape; Visualization software; Vocabulary; analytical method; biobank; bioinformatics resource; clinical database; cohort; data exchange; data integration; data management; data quality; design; education research; electronic health database; flexibility; improved; informatics tool; innovation; interoperability; investigator training; novel; open source; query tools; rare condition; research study; statistical learning; statistics; symposium; tool; translational scientist; web site

Massachusetts Alzheimer’s Disease Research Center: Data Core The Data Management and Statistics Core (Data Core) of the Massachusetts Alzheimer’s Disease Research Center (MADRC) provides state-of-the-art data management and statistical expertise for the MADRC and affiliated research studies, for collaborative efforts with other ADRCs, and for national AD/ADRD research initiatives. The Data Core is an essential component of the MADRC research enterprise as it facilitates scientific rigor, regulatory-compliance and strong connectedness across cores within our Center, and with NACC and others outside our Center. It serves to minimize the burdens of research by optimizing study efficiencies through subject selection, endpoint selection, facile and adaptive designs, as well as provides guidance on rigorous study design and analyses. The Data Core provides informatics expertise and assistance, including data-management, timely data transmission to NACC, and query and reporting support to all the MADRC Cores. We will contribute to MADRC’s goal of understanding heterogeneity through formal statistical modeling and use of latent variables, through statistical learning approaches that accommodate longitudinal and survival data under biased sampling and through analysis of omics data. We will contribute to MADRC’s goal of accelerating toward a cure by developing, importing and disseminating innovative statistical methods and informatics tools that will optimize resources. The Core aims to marshal resources (Aims 1,2) to support clinical, translational, and basic research in AD/ADRD by contributing statistical and informatics expertise to interdisciplinary teams. The Core aims to develop new strategies (Aims 3,4) to provide practical and efficient study designs and unbiased analytic methods, and to implement innovative informatics resources. The Core aims to build the future (Aims 5,6) by collaborating with the Research Education Component (REC) to train clinical and translational researchers in quantitative methods and to attract quantitative scientists to AD/ADRD research. The Data Core provides guidance on scientific rigor: it assists MADRC researchers with study design and ensures valid and accurate analyses of studies across all MADRC Cores. The Data Core also advises MADRC researchers on data quality, version control and tracking measures. It ensures all systems are secure and within the Partners IT Infrastructure. The Core promotes open and reproducible science by disseminating methodological innovations to the scientific community and through data and software sharing.

马萨诸塞州阿尔茨海默氏病研究中心：数据核心 马萨诸塞州阿尔茨海默氏病研究的数据管理和统计核心（数据核心） 中心（MADRC）为MADRC和 会员研究，与其他ADRC进行合作以及国家广告/ADRD研究 倡议。数据核心是MADRC研究企业的重要组成部分，因为它有助于 科学严谨，遵守法规符合性和跨核心的紧密联系，并与 NACC和我们中心外的其他人。它通过优化研究来最大程度地减少研究的伯恩。 通过主题选择，端点选择，便捷和自适应设计的效率，并提供 严格的研究设计和分析指南。数据核心提供了信息的专业知识和 协助，包括数据管理，及时向NACC传输数据以及查询和报告支持 所有的马德核心。 我们将为马德克的目标做出贡献，即通过正式的统计建模和 通过适应纵向和生存数据的统计学习方法的使用，使用潜在变量 在偏见的采样和通过分析OMICS数据下。我们将为马德克的目标做出贡献 通过开发，进口和传播创新的统计方法和 提供优化资源的信息工具。核心旨在元帅资源（目标1,2）支持 通过贡献统计和信息专业知识， 跨学科团队。核心旨在制定新策略（目标3,4），以提供实用和高效 研究设计和公正的分析方法，并实施创新的信息资源。核心 旨在通过与研究教育部分（REC）合作培训来建立未来（目标5,6） 定量方法的临床和翻译研究人员，并吸引定量科学家进行AD/ADRD 研究。 数据核心提供了有关科学严谨的指导：它协助马德里研究人员进行研究设计和 确保对所有MADRC核心研究的有效和准确分析。数据核心还建议MADRC 数据质量，版本控制和跟踪措施的研究人员。它确保所有系统都安全，并且 在合作伙伴中IT基础架构。核心通过传播来促进开放和可重复的科学 通过数据和软件共享对科学界的方法论创新。