Pre-exposure prophylaxis (PrEP) information on social media

社交媒体上的暴露前预防 (PrEP) 信息

• 批准号: 10619946
• 负责人: Eric Richard Walsh-Buhi
• 金额: $ 21.02万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-09 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10619946
• 关键词: 18 year old; AIDS prevention; Address; Adherence; Adolescent; Adult; Anal Sex; Area; Awareness; Behavioral; Bisexual; Black Populations; Black race; Characteristics; Clinic; Clinical Trials; Code; Cohort Studies; Communication; Couples; Data; Development; Diffusion; Education; Epidemic; Evaluation; FDA approved; Facebook; Future; Gays; HIV; HIV Infections; HIV Seronegativity; HIV diagnosis; HIV risk; HIV/AIDS; Health; Heterosexuals; Human; Human immunodeficiency virus test; Individual; Injectable; Injecting drug user; Instagram; Institution; Intervention; Knowledge; Lesbian; Lesbian Gay Bisexual Transgender Queer; Libraries; Methods; Modality; Modeling; Oral; Persons; Population; Populations at Risk; Prevention; Prevention strategy; Probability; Reporting; Research; Research Project Grants; Risk; Risk Reduction; Sampling; Services; Social Marketing; Social Network; Source; Testing; Theory of Change; Training; Twitter; Update; Youth; aged; analytical method; behavior change; black men who have sex with men; cis-male; condoms; cost; design; digital tool; evidence base; gender diversity; health communication; human centered design; improved; infection burden; innovation; machine learning method; medication compliance; men; men who have sex with men; multidisciplinary; multilevel analysis; new technology; nonbinary; pilot test; posters; pre-exposure prophylaxis; predictive modeling; recruit; sexually active; social influence; social media; social stigma; study population; theories; transgender; transgender women; uptake

Project Abstract The continuing HIV epidemic in the U.S. remains a critical health issue for young priority populations bearing a disproportionate burden of infection. Daily oral PrEP (and as of December 2021, a long-acting injectable cabotegravir) is safe and effective in reducing the risk of sexual HIV acquisition in adults and adolescents, yet PrEP awareness/usage remains low. Accordingly, interventions are sorely needed to address PrEP awareness and mitigate potential barriers related to PrEP use. One such intervention modality is social media (SM), as HIV knowledge, PrEP awareness, and communicating issues, such as access and cost, are easily addressable via clear SM messages on platforms young people already use frequently. Given that PrEP awareness/usage remains low and that SM may be a viable intervention modality for increasing PrEP facilitators and reducing barriers, the overall objective of this proposed exploratory research project is to 1) characterize the SM landscape regarding PrEP and HIV prevention messages and 2) develop new and improved behavioral theory-based messages about PrEP that are clear, specific, consistent, and scientifically up to date. With a robust and multidisciplinary team across 2 institutions, we will accomplish this objective via 3 SPECIFIC AIMS: AIM 1: Characterize PrEP-related communications across 3 popular social media platforms (Facebook, Instagram, and Twitter), identifying message and source characteristics. Using content analytic methods, we will access, human code, and analyze publicly available PrEP-related SM posts/messages, describing features of messages, posters/users, and social networks. AIM 2: Build a predictive, explainable health communication model, guided by the Multilevel Model of Meme Diffusion (M3D), to determine the diffusion potential of PrEP-related messages. We will apply machine learning methods to characterize PrEP message features; develop/evaluate a predictive model of a message diffusion potential using large-scale training data; and apply the model to predict a set of online diffusion metrics for a given message and assess its ability to reach online PrEP-relevant populations. AIM 3: Develop and pilot test PrEP promotion messages, for several young priority populations, for implementation/evaluation in a future project. Using human- centered design (HCD) principles, we will engage 2-3 end-user segments in iterative rounds of SM message development and testing. This proposed R21 will yield a deeper understanding of PrEP promotion messaging on SM and produce a “library of messages,” tailored for several young priority populations at risk for HIV. Such messages will be empirically tested in a future R01 project, and assessed for evidence of behavior change (i.e., PrEP usage). Such knowledge may be employed in innovative/targeted efforts via well-liked and accessible digital tools, such as SM, effectively supporting the updated National HIV/AIDS Strategy for the U.S.

项目摘要 美国艾滋病毒的持续流行对于年轻的优先人群来说仍然是一个严重的健康问题 每日口服 PrEP（截至 2021 年 12 月，长效注射剂）的感染负担过大。 cabotegravir）可安全有效地降低成人和青少年性感染艾滋病毒的风险，但 PrEP 认知度/使用率仍然较低，因此，迫切需要采取干预措施来解决 PrEP 认知度问题。 并减轻与 PrEP 使用相关的潜在障碍，其中一种干预方式是社交媒体 (SM)，如艾滋病毒。 知识、PrEP 意识和沟通问题（例如获取和成本）可以通过以下方式轻松解决： 鉴于 PrEP 意识/使用情况，在年轻人经常使用的平台上发布清晰的 SM 信息。 仍然很低，SM 可能是增加 PrEP 促进者和减少风险的可行干预方式 障碍，本提议的探索性研究项目的总体目标是 1) 描述 SM 景观的特征 关于 PrEP 和 HIV 预防信息，2) 开发新的和改进的基于行为理论的 有关 PrEP 的信息清晰、具体、一致且科学最新。 跨 2 个机构的多学科团队，我们将通过 3 个具体目标实现这一目标：目标 1： 描述 3 个流行社交媒体平台（Facebook、Facebook、 Instagram 和 Twitter），使用内容分析方法识别消息和来源特征。 我们将访问人类代码并分析公开的与 PrEP 相关的 SM 帖子/消息，描述 消息、海报/用户和社交网络的特征 目标 2：建立可预测的、可解释的健康。 通信模型，以模因扩散多级模型 (M3D) 为指导，确定 PrEP 相关信息的传播潜力 我们将应用机器学习方法来表征 PrEP。 消息特征；开发/评估大规模消息传播潜力的预测模型 训练数据；并应用该模型来预测给定消息的一组在线传播指标并评估其 能够接触到在线 PrEP 相关人群 目标 3：开发和试点测试 PrEP 推广信息， 针对几个年轻的优先人群，在未来的项目中实施/评估。 以中心设计（HCD）原则，我们将让 2-3 个最终用户群体参与迭代的 SM 消息 拟议的 R21 的开发和测试将使人们对 PrEP 推广信息有更深入的了解。 并为一些面临艾滋病毒风险的年轻优先人群量身定制“信息库”。 消息将在未来的 R01 项目中进行实证测试，并评估行为改变的证据（即， PrEP 的使用）。这些知识可以通过广受欢迎且易于理解的方式用于创新/有针对性的工作中。 SM 等数字工具有效支持更新后的美国国家艾滋病毒/艾滋病战略