Stephenson Cancer Center - Cancer Center Support Grant

史蒂芬森癌症中心 - 癌症中心支持补助金

• 批准号: 10906448
• 负责人: ROBERT S. MANNEL
• 金额: $ 52.33万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10906448
• 关键词: Address; African American; American Indians; Biomedical Research; Black race; Cancer Center; Cancer Center Support Grant; Cancer health equity; Catchment Area; Clinical; Clinical Trials; Collaborations; Colon Carcinoma; Communities; Community Outreach; Disparity; Education; Ensure; Faculty; Fostering; Funding; Goals; Grant; Growth; Health; Health Professional; Health Technology; Incidence; Individual; Infrastructure; Intervention; Investments; Leadership; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of pancreas; Mentorship; Minority Groups; Mission; NCI-Designated Cancer Center; Oklahoma; Oncology; Persons; Population; Positioning Attribute; Publications; Reporting; Research; Research Activity; Research Peer Review; Resources; Rural Population; Science; Site; Strategic Planning; Students; Therapeutic; Training; Training Activity; Translating; Translations; Tribes; United States National Institutes of Health; Universities; Vision; Vulnerable Populations; Woman; cancer care; cancer health disparity; cancer prevention; cancer risk; community setting; design; health equity; health equity promotion; improved outcome; innovation; mHealth; member; morphogens; mortality; multidisciplinary; next generation; novel; outreach; patient oriented; programs; recruit; social health determinants; tobacco control; underserved minority

OVERALL: ABSTRACT Since achieving NCI designation in 2018, the Stephenson Cancer Center (SCC) at the University of Oklahoma has continued to grow and mature as an organization. The SCC’s vision to eliminate cancer in Oklahoma and beyond is advanced through its mission to provide patient-centered, research-driven, multidisciplinary cancer care to all Oklahomans. As Oklahoma’s only NCI-designated cancer center, the SCC serves a statewide catchment area that presents unique challenges with social determinants of health and high disparities in cancer incidence and mortality, especially for the state’s American Indian (AI), Black/African American, and rural populations. The SCC has the ability to be impactful in its catchment area and nationally due to strategically targeted recruitments and investments that have leveraged key differentiating factors: 1) the SCC continues to invest in creating and sustaining health and research partnerships with AI tribal partners throughout Oklahoma and currently has 22 NIH funded projects addressing AI cancer disparities; 2) the SCC continues to be a national leader in the NCI/NCTN and has established a statewide network of affiliate sites to ensure access to NCI-sponsored clinical trials throughout its catchment area; 3) the SCC has developed strong team-based research across all of its programs with national leadership in gynecologic, colon, and pancreatic cancers, cancer prevention, cancer therapeutics, gero-oncology, and tobacco control; and 4) the SCC is building upon its national leadership in mobile health technologies to address the burden on cancer in rural and vulnerable populations. Multiple NCI CCSG metrics emphasize the growth and maturation of the SCC during the reporting period (2017-21). SCC membership increased from 83 to 120 (45%), with 31 of these new members being externally recruited to add expertise to programs. Annual, peer-reviewed research funding (DC) grew 61% ($14.28M  $22.97M) and total annual research funding grew 42% ($30.13M  $43.09M). The overall five-year number of scientific publications has increased by 54% since the last reporting period (945  1,454), with 16% having an impact factor ≥10 (up from 7%). Team science has been emphasized resulting in 139 collaborative grants (36% increase) and a 17% inter-programmatic publication rate (up from 4%) over the prior reporting period. The number of annual active interventional IITs has doubled from 20 to 40 over the past five years, with annual accruals to interventional IITs increasing from 661 (2017) to 927 (2021) – a 40% increase. This degree of impactful growth has been possible due to the infrastructure made available through the CCSG and has positioned the SCC for a successful renewal as a NCI-designated cancer center.

总体：摘要 自2018年获得NCI指定以来，俄克拉荷马大学的斯蒂芬森癌症中心（SCC） 作为一个组织，继续成长并成熟。 SCC消除俄克拉荷马州癌症的愿景和 通过其使命提供以患者为中心的，以研究为导向的多学科癌症的使命，超越了 照顾所有俄克拉荷马人。作为俄克拉荷马州唯一的NCI指定的癌症中心，SCC在全州范围内服务 集水区，以健康的社会决定者和高度差异提出了独特的挑战 癌症发病率和死亡率，特别是对该州的美洲印第安人（AI），黑人/非裔美国人和 农村人口。 SCC具有在其集水区的影响力，并且由于 策略性地针对利用主要区别因素的招聘和投资：1）SCC 继续投资于与AI部落合作伙伴建立和维持健康和研究合作伙伴关系 在整个俄克拉荷马州，目前拥有22个NIH资助的项目，这些项目针对AI癌症分布； 2）SCC 继续是NCI/NCTN的国家领导者，并建立了全州范围的会员网站网络 确保在整个集水区中访问NCI赞助的临床试验； 3）SCC发展了很强 基于团队的研究在其所有计划中都具有妇科，结肠和胰腺的国家领导 癌症，预防癌症，癌症治疗，Gero肿瘤学和烟草控制； 4）SCC是 基于其在移动健康技术方面的国家领导地位，以解决农村癌症的烧伤和 脆弱的人群。 多个NCI CCSG指标强调报告期SCC的增长和成熟 （2017-21）。 SCC会员资格从83个增加到120（45％），其中31名新成员在外部 招募以增加计划的专业知识。一年一度的，同行评审的研究资金（DC）增长61％（1428万美元 2297万美元）和年度研究资金增长42％（$ 3013亿美元4309万美元）。总五年 自上次报告期（9451,454）以来，科学出版物已增长了54％，其中16％ 影响因子≥10（从7％高出）。团队科学已被强调，导致139个合作赠款 （增长36％）和前期报告期间的17％的截期发表率（高于4％）。 在过去的五年中，年度活跃介入的IIT数量从20倍到40个增加了一倍，年度 对介入的IIT的应计增长率从661（2017）增加到927（2021），增长了40％。这个程度 由于通过CCSG提供的基础设施，有影响力的增长是可能的 将SCC定位为成功续签，成为NCI指定的癌症中心。