Skin-like wearable biosensors for multimodal mental health biomarker monitoring

用于多模式心理健康生物标志物监测的类肤可穿戴生物传感器

• 批准号: 10750863
• 负责人: Chuanzhen Zhao
• 金额: $ 7.18万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10750863
• 关键词: Acute; Affect; Anxiety; Behavioral Sciences; Biological Markers; Biosensing Techniques; Biosensor; Body Temperature; Cardiovascular Diseases; Chemicals; Chronic stress; Circadian Rhythms; Clinical; DNA; Data; Data Collection; Detection; Development; Device Designs; Devices; Diagnosis; Electrical Engineering; Electrodes; Environment; Feedback; Galvanic Skin Response; Glucose; Goals; Health Personnel; Health Services Accessibility; Health Status; Hormones; Hospitals; Human body; Hydrocortisone; Hydrogels; Immune response; Individual; Knowledge; Measurable; Measurement; Measures; Mental Depression; Mental Health; Mental Health Services; Mental disorders; Mentors; Molecular Conformation; Monitor; Morphologic artifacts; Motion; National Institute of Biomedical Imaging and Bioengineering; Noise; Patients; Persons; Physiological; Prevention; Psychiatry; Research; Research Project Grants; Research Proposals; Resources; Scientist; Secure; Signal Transduction; Skin; Stigmatization; Stress; System; Techniques; Technology; Testing; Time; Training; Transistors; Translations; Universities; Work; acute stress; aptamer; bioelectronics; career; cost; data exchange; design; experience; fabrication; flexibility; high risk; human subject; insight; mental disorder prevention; mental state; monitoring device; multimodality; new technology; novel; personalized health care; post-doctoral training; prevent; printed circuit board; professor; psychobiologic; real world application; response; sensor; skills; social; social stigma; stress state; stressor; technology platform; tool; wearable device; wearable platform; wearable sensor technology; wireless; wireless electronic; wireless sensor; Acute; Affect; Anxiety; Behavioral Sciences; Biological Markers; Biosensing Techniques; Biosensor; Body Temperature; Cardiovascular Diseases; Chemicals; Chronic stress; Circadian Rhythms; Clinical; DNA; Data; Data Collection; Detection; Development; Device Designs; Devices; Diagnosis; Electrical Engineering; Electrodes; Environment; Feedback; Galvanic Skin Response; Glucose; Goals; Health Personnel; Health Services Accessibility; Health Status; Hormones; Hospitals; Human body; Hydrocortisone; Hydrogels; Immune response; Individual; Knowledge; Measurable; Measurement; Measures; Mental Depression; Mental Health; Mental Health Services; Mental disorders; Mentors; Molecular Conformation; Monitor; Morphologic artifacts; Motion; National Institute of Biomedical Imaging and Bioengineering; Noise; Patients; Persons; Physiological; Prevention; Psychiatry; Research; Research Project Grants; Research Proposals; Resources; Scientist; Secure; Signal Transduction; Skin; Stigmatization; Stress; System; Techniques; Technology; Testing; Time; Training; Transistors; Translations; Universities; Work; acute stress; aptamer; bioelectronics; career; cost; data exchange; design; experience; fabrication; flexibility; high risk; human subject; insight; mental disorder prevention; mental state; monitoring device; multimodality; new technology; novel; personalized health care; post-doctoral training; prevent; printed circuit board; professor; psychobiologic; real world application; response; sensor; skills; social; social stigma; stress state; stressor; technology platform; tool; wearable device; wearable platform; wearable sensor technology; wireless; wireless electronic; wireless sensor

PROJECT SUMMARY Mental disorders affect one in four people worldwide (~2 billion people), with the cost of mental health conditions projected to reach $6 trillion by 2030. Unfortunately, mental disorders are difficult to diagnose, monitor, and treat. Repeated triggering of daily stress can also lead to chronic stress, associated with higher risks of mental disorders, weakening immuneresponse, and cardiovascular diseases. Despite the mental health crisis, available resources and access to care scarcely begin to meet the need. Moreover, there are no objective tests or scalable technologies for detecting chronic stress. To advance precision mental healthcare, we need continuous, predictive, and quantitative measurements of mental states for stress, anxiety, and depression. Wearable devices can transform mental health care due to their ability to monitor previously inaccessible biodata. However, there are limited wearable devices designed for mental health monitoring. In the proposed research, I will tackle the mentioned problems in mental health monitoring by developing platform technologies based on skin-like wearable biosensors. The focus of the proposed study is to create a soft and wearable biosensor that can measure multiple mental health biomarkers wirelessly in real-time, providing quantifiable metrics to assist diagnosis, treatment, monitoring, and prevention of mental disorders. Two new technologies will be developed: a soft and wireless patch to measure mental health-related physical biomarkers on the skin and a new organic biosensor platform to monitor chemical biomarkers in sweat. First, I will design a soft and wireless sensor patch to monitor skin conductance changes in response to acute stressors and circadian rhythm. The designed skin conductance sensor patch, composed of intrinsically stretchable and soft materials, will provide seamless integration with skin and accurate measurement with high signal-to-noise ratios. Second, I will fabricate a soft chemical biosensor to monitor the stress hormone in sweat using organic field-effect transistors. A highly sensitive and selective aptamer chemical biosensor will be utilized in a skin-like organic material system. Both alone and combined, the skin-like wearable systems will allow continuous quantitative monitoring of mental health biomarkers, assisting in the prevention and treatment of mental disorders. Professor Zhenan Bao, Professor Leanne Williams, and Stanford University provide the tools and expertise needed to accomplish the proposed research. Working with Professor Bao, a leading scientist in the field of intrinsically stretchable materials, I will acquire scientific skills in the design, fabrication, and characterization techniques of organic materials and bioelectronics. In addition, I will gain experience working with human subjects during this postdoctoral training. For this reason, I am working with Professor Williams, my co-mentor, who is a leading professor in psychiatry and behavioral sciences. Moreover, I will obtain training in psychiatry and electrical engineering by taking classes at Stanford. This environment provides the expertise needed to accomplish the proposed research and provide me with the appropriate training to pursue a career in academic research.

项目摘要 精神障碍影响全球四分之一的人（约20亿人），其精神健康状况的成本 预计到2030年将达到6万亿美元。不幸的是，精神障碍很难诊断，监测和治疗。 重复触发日常压力也可能导致慢性压力，与更高的心理风险有关 疾病，免疫响应和心血管疾病。尽管精神健康危机，可用 资源和护理机会几乎无法开始满足需求。此外，没有客观测试或可扩展的 检测慢性应激的技术。为了提高精度心理保健，我们需要连续 精神状态的预测和定量测量，以减轻压力，焦虑和抑郁。可穿戴 由于能够监视以前无法接近的生物疾病，设备可以改变心理保健。然而， 设计用于心理健康监测的可穿戴设备有限。在拟议的研究中，我将解决 通过开发基于皮肤的平台技术，提到的心理健康监测问题 可穿戴生物传感器。拟议的研究的重点是创建一个柔软可穿戴的生物传感器，可以 实时测量多个心理健康生物标志物，提供可量化的指标来协助 诊断，治疗，监测和预防精神障碍。将开发两种新技术： 一种柔软无线的补丁，可在皮肤上测量与心理健康相关的物理生物标志物和新的有机物 生物传感器平台监测汗水中的化学生物标志物。首先，我将设计一个柔软的无线传感器补丁 以响应急性应激源和昼夜节律而监测皮肤电导的变化。设计的皮肤 由本质上可拉伸和柔软材料组成的电导传感器贴片将提供无缝的 与皮肤和准确的测量与高信噪比相结合。其次，我会捏造一个柔软的 化学生物传感器使用有机田间效应晶体管监测汗液中的应激激素。高度 敏感和选择性的适体化学生物传感器将用于皮肤样有机材料系统。两个都 单独并结合使用，皮肤般的可穿戴系统将允许对心理进行持续的定量监控 卫生生物标志物，协助预防和治疗精神障碍。 Zhenan Bao教授， Leanne Williams教授和Stanford University提供了实现这一目标所需的工具和专业知识 拟议的研究。与Bao教授合作，Bao教授是本质上可拉伸领域的主要科学家 材料，我将获得有机设计，制造和表征技术方面的科学技能 材料和生物电子学。此外，在此期间，我将获得与人类主题合作的经验 博士后培训。因此，我正在与我的同事威廉姆斯教授合作，后者是领导者 精神病学和行为科学教授。而且，我将获得精神病学和电气的培训 通过在斯坦福大学上课的工程。这个环境提供了完成的专业知识 拟议的研究，并为我提供适当的培训，以从事学术研究的职业。