Examining Factors of Phantom Limb Pain through Person-Centered Assessment

通过以人为本的评估检查幻肢痛的因素

• 批准号: 10750561
• 负责人: Kierra J Falbo
• 金额: $ 4.51万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-29 至 2026-09-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10750561
• 关键词: Address; Amputation; Anxiety; Biomedical Engineering; Cellular Phone; Characteristics; Clinic Visits; Clinical Treatment; Data; Data Analyses; Data Discovery; Development; Ecological momentary assessment; Engineering; Environment; Environmental Risk Factor; Focus Groups; Frequencies; Future; Goals; Health Care Costs; Heterogeneity; Impairment; Individual; Interview; Laboratories; Lower Extremity; Measures; Medical center; Mental Depression; Mentors; Mentorship; Method Acceptability; Methods; Migraine; Minnesota; Mission; Nature; Notification; Outcome; Pain; Pain management; Participant; Patients; Persons; Phantom Limb Pain; Population; Positioning Attribute; Predictive Factor; Prosthesis; Protocols documentation; Public Health; Qualitative Research; Quality of life; Recommendation; Reporting; Research; Research Infrastructure; Research Personnel; Review Literature; Rheumatoid Arthritis; Sampling; Science; Structure; Survey Methodology; Surveys; Techniques; Testing; Time; Training; Universities; Work; acceptability and feasibility; career; chronic pain; clinical care; clinical practice; contextual factors; design; disability; effective intervention; evidence base; experience; handheld mobile device; improved; ineffective therapies; innovation; interest; limb amputation; multidisciplinary; pain reduction; participant retention; person centered; personalized medicine; precision medicine; programs; recruit; rehabilitation research; rehabilitation science; research data dissemination; response; retention rate; skills; stem; success; symptom management; therapy design; Address; Amputation; Anxiety; Biomedical Engineering; Cellular Phone; Characteristics; Clinic Visits; Clinical Treatment; Data; Data Analyses; Data Discovery; Development; Ecological momentary assessment; Engineering; Environment; Environmental Risk Factor; Focus Groups; Frequencies; Future; Goals; Health Care Costs; Heterogeneity; Impairment; Individual; Interview; Laboratories; Lower Extremity; Measures; Medical center; Mental Depression; Mentors; Mentorship; Method Acceptability; Methods; Migraine; Minnesota; Mission; Nature; Notification; Outcome; Pain; Pain management; Participant; Patients; Persons; Phantom Limb Pain; Population; Positioning Attribute; Predictive Factor; Prosthesis; Protocols documentation; Public Health; Qualitative Research; Quality of life; Recommendation; Reporting; Research; Research Infrastructure; Research Personnel; Review Literature; Rheumatoid Arthritis; Sampling; Science; Structure; Survey Methodology; Surveys; Techniques; Testing; Time; Training; Universities; Work; acceptability and feasibility; career; chronic pain; clinical care; clinical practice; contextual factors; design; disability; effective intervention; evidence base; experience; handheld mobile device; improved; ineffective therapies; innovation; interest; limb amputation; multidisciplinary; pain reduction; participant retention; person centered; personalized medicine; precision medicine; programs; recruit; rehabilitation research; rehabilitation science; research data dissemination; response; retention rate; skills; stem; success; symptom management; therapy design

PROJECT SUMMARY Phantom limb pain is common after amputation, but the mechanisms and associated factors contributing to this pain remain unclear. Without an understanding of associated factors, it is difficult for clinicians to recommend effective pain treatments. The long-term goal of this research is to better understand contributing factors to phantom limb pain on an individual level to guide effective, personalized treatment approaches in the future. The overall objective of this project is to establish the feasibility and acceptability of the ecological momentary assessment (EMA) method in measuring person-centered factors contributing to phantom limb pain. EMA is a systematic survey methodology to evaluate real-time personal and environmental factors in an individual’s natural environment. The hypothesis is that EMA surveys will achieve at least 80% retention rate and 75% response rate in the amputation population. This hypothesis will be tested through two specific aims. Aim 1: Investigate factors contributing to phantom limb pain among individuals with amputations. The approach for this aim will be to conduct focus group sessions with individuals with amputations to discuss their experiences with phantom limb pain and any aggravating or relieving factors. Data from the focus groups will be used to refine a list of EMA questions on phantom limb pain contributing factors. Aim 2: Determine the feasibility and acceptability of EMA to identify phantom limb pain factors. The approach for this aim will be to use repeated EMA surveys to measure phantom limb pain and its contributing factors in individuals with amputations in real time and in their natural environment. Responses to EMA questions will be analyzed to explore factors that contribute to phantom limb pain in each participant. The feasibility and acceptability of this method in this population will be determined using recruitment rate, retention rate, response rate, and semi- structured interviews with participants. This proposed research will contribute to science through an improved understanding of contributing factors to phantom limb pain after amputation and the establishment of feasibility and acceptability of the EMA method in measuring these factors. These contributions are expected to be significant because the systematic identification of patient-specific factors will guide informed future treatment recommendations for effective, personalized medicine for phantom limb pain, addressing a critical public health need. This research is part of a comprehensive training plan that includes advanced coursework on qualitative research and causal discovery data analysis, professional development through seminars, networking, and research dissemination, and mentored training in the research skills needed to continue the applicant’s trajectory to becoming an independent researcher. The University of Minnesota’s expansive research infrastructure, the multidisciplinary doctoral program in Rehabilitation Science, and the Minneapolis Adaptive Design and Engineering laboratory create an ideal environment for completing this research and training.

项目摘要 截肢后的幻影肢体疼痛是常见的，但是导致此的机制和相关因素 疼痛尚不清楚。没有了解相关因素，临床医生很难推荐 有效的疼痛治疗。这项研究的长期目标是更好地了解 幻影肢体疼痛在个人层面上，以指导未来有效的个性化治疗方法。 该项目的总体目标是确定生态瞬间的可行性和可接受性 评估（EMA）方法在测量以人为中心的因素导致幻影肢体疼痛的方法。 Ema是一个 系统的调查方法，以评估个人的实时个人和环境因素 自然环境。假设是EMA调查将至少达到80％的保留率和75％ 截肢人群的回应率。该假设将通过两个具体目标进行检验。目标1： 研究有助于肢体肢体疼痛的因素。这 实现此目标的方法是与有截肢的人进行焦点小组会议，以讨论他们的 幻影肢体疼痛以及任何加重或缓解因素的经历。焦点小组的数据将 用于完善有关幻影肢体疼痛促成因素的EMA问题的清单。目标2：确定 EMA识别幻影肢体疼痛因素的可行性和可接受性。这个目标的方法 使用重复的EMA调查来测量幻影肢体疼痛及其在患有 实时截肢及其自然环境。将对EMA问题的回答分析 探索导致每个参与的幻影肢体疼痛的因素。此的可行性和可接受性 该人群中的方法将使用招聘率，保留率，反应率和半 与参与者的结构化访谈。这项拟议的研究将通过改进来为科学做出贡献 理解截肢后幻影肢体疼痛的因素和可行性的建立 EMA方法在测量这些因素方面的可接受性。这些贡献预计将是 意义重大，因为对患者特异性因素的系统识别将指导知情的未来治疗 建议有效的个性化药物幻影肢体疼痛，解决关键的公共卫生 需要。这项研究是一项全面培训计划的一部分，该计划包括定性的高级课程 研究和因果发现数据分析，通过半手，网络和网络的专业发展和 研究传播，并为继续申请人的研究技能进行了指导的培训 成为独立研究人员的轨迹。明尼苏达大学的广泛研究 基础设施，康复科学的多学科博士课程和明尼阿波利斯自适应 设计和工程实验室为完成这项研究和培训创造了理想的环境。