Trajectories and Environments in Autism: a Multi-cohort Study (TEAMS) following autism families in ECHO Phase 2

自闭症的轨迹和环境：ECHO 第 2 阶段中对自闭症家庭进行的多队列研究 (TEAMS)

• 批准号: 10745068
• 负责人: KRISTEN Lyall
• 金额: $ 113.7万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745068
• 关键词: Abbreviations; Address; Adolescence; Adolescent; Adult; Age; Air Pollutants; Air Pollution; Area; Attention deficit hyperactivity disorder; Automobile Driving; Behavioral; Child; Child Health; Childhood; Cohort Studies; Collection; Communities; Cross-Sectional Studies; Data; Data Collection; Diagnosis; Diagnostic; Diet; Dietary Factors; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Etiology; Exposure to; Family; Fatty Acids; Fishes; Folic Acid; General Population; Genetic; Genetic Variation; Goals; Health; Healthcare; Healthy Eating; Heritability; Incentives; Intake; Intellectual functioning disability; Joints; Language; Life; Longevity; Longitudinal Studies; Measurement; Measures; Mental Health; Methods; Modification; Names; Neighborhoods; Neurodevelopmental Disorder; Nutrient; Outcome; Participant; Pattern; Personal Satisfaction; Phase; Phenotype; Play; Population; Prevalence; Property; Protocols documentation; Psyche structure; Psychometrics; Research; Resources; Risk; Risk Factors; Role; Sample Size; Science; Siblings; Site; Uterus; Work; adolescent health outcomes; adolescent with autism spectrum disorder; adult with autism spectrum disorder; age group; autism spectrum disorder; autistic; autistic children; care burden; cohort; dietary; dimensional analysis; early childhood; early life exposure; emerging adult; epidemiology study; follow-up; health assessment; indexing; individuals with autism spectrum disorder; neurodevelopment; outcome prediction; physical conditioning; polygenic risk score; prenatal; prenatal exposure; programs; recruit; retention rate; sex; support network; trait; Abbreviations; Address; Adolescence; Adolescent; Adult; Age; Air Pollutants; Air Pollution; Area; Attention deficit hyperactivity disorder; Automobile Driving; Behavioral; Child; Child Health; Childhood; Cohort Studies; Collection; Communities; Cross-Sectional Studies; Data; Data Collection; Diagnosis; Diagnostic; Diet; Dietary Factors; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Etiology; Exposure to; Family; Fatty Acids; Fishes; Folic Acid; General Population; Genetic; Genetic Variation; Goals; Health; Healthcare; Healthy Eating; Heritability; Incentives; Intake; Intellectual functioning disability; Joints; Language; Life; Longevity; Longitudinal Studies; Measurement; Measures; Mental Health; Methods; Modification; Names; Neighborhoods; Neurodevelopmental Disorder; Nutrient; Outcome; Participant; Pattern; Personal Satisfaction; Phase; Phenotype; Play; Population; Prevalence; Property; Protocols documentation; Psyche structure; Psychometrics; Research; Resources; Risk; Risk Factors; Role; Sample Size; Science; Siblings; Site; Uterus; Work; adolescent health outcomes; adolescent with autism spectrum disorder; adult with autism spectrum disorder; age group; autism spectrum disorder; autistic; autistic children; care burden; cohort; dietary; dimensional analysis; early childhood; early life exposure; emerging adult; epidemiology study; follow-up; health assessment; indexing; individuals with autism spectrum disorder; neurodevelopment; outcome prediction; physical conditioning; polygenic risk score; prenatal; prenatal exposure; programs; recruit; retention rate; sex; support network; trait

Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders diagnosed in childhood, with a prevalence of 2% or higher. ASD presents along a spectrum, and characterization according to quantitative measures demonstrates continuous distribution of core traits extending into the general population. While both ASD diagnosis and ASD-related traits have been shown to be highly heritable, evidence also supports contributions of environmental risk factors, including prenatal exposure to air pollution and intake of certain nutrients. In order to address prior gaps in the understanding of environmental risk factors for autism, our team developed the Autism Spectrum Disorder Enriched Risk (ASD-ER) “cohort of cohorts.” In the first phase of ECHO, our cohort contributed to harmonization efforts of diet, air pollution, and neurodevelopment, and advanced use of abbreviated measures of the ASD-related phenotype, while capitalizing on the unique data for autism research presented by ECHO. Here, we propose to build off of these efforts while continuing follow-up of ASD-ER ECHO Phase-1 children through the critical and under-studied period of adolescence and early adulthood in the Trajectories and Environments in Autism: a Multi-cohort Study (TEAMS) project. The goals of this project are to: 1) Examine joint effects of early life air pollution exposure and diet on neurodevelopmental outcomes in ECHO-wide data, addressing the role that folate, fish/fatty acids, and other dietary factors may play in mitigating air pollution associations across neurodevelopmental diagnoses and their related quantitative traits (ASD, ID, and ADHD); 2) Evaluate multi-domain health trajectories of adolescents across neurodevelopmental outcomes in ECHO-wide data, and identify predictors of positive trajectories and outcomes. Using the unique longitudinal data collected through ECHO efforts, we will examine trajectories across mental and physical health and examine how these differ across neurodevelopmental diagnoses and traits. We will also seek to further characterize our specialized outcome area of neurodevelopment, and autism specifically, by conducting psychometric analyses of dimensional measures. Finally, we will 3) Maximize recruitment and retention of our cohort participants via implementation of the ECHO protocol. We will implement a unified recruitment and retention strategy facilitated by incentives and a network of support for adolescents with neurodevelopmental conditions, transition-age autistic youth, and their families. TEAMS will be the first longitudinal study of autistic younger sibling children followed from the womb to adulthood. In doing so, our project presents unique opportunities to advance understanding of environmental predictors and modifiers, conduct cross-outcome comparisons of neurodevelopmental disorders and their latent traits, characterize multi-domain trajectories and identify predictors of positive outcomes in autistic adolescents, and implement the ECHO Phase 2 protocol to ensure an expanded set of research possibilities in this important population, and ultimately, optimize outcomes for autistic individuals and their families.

自闭症谱系障碍（ASD）是最常见的神经发育障碍之一 童年，患病率为2％或更高。 ASD沿频谱呈现，并根据表征 定量措施表明，延伸到一般的核心特征的连续分布 人口。尽管ASD诊断和与ASD相关的特征都被证明是高度可遗传的，但证据 还支持环境风险因素的贡献，包括产前暴露于空气污染和摄入量 某些营养素。为了解决对自闭症环境风险因素的理解， 我们的团队开发了自闭症谱系障碍富含风险（ASD-ER）的“同类队列”。在第一阶段 回声，我们的队列有助于饮食，空气污染和神经发育的统一努力以及 高级使用ASD相关表型的缩写措施，同时利用了独特的数据 自闭症研究由Echo提出。在这里，我们建议在继续进行这些努力的同时继续进行这些努力 通过青少年和早期的关键和研究不足的时期ASD-ER Echo 1阶段儿童 在自闭症的轨迹和环境中成年：多核研究（团队）项目。目标 该项目是：1）检查早期生命的空气污染暴露和饮食对 回声范围数据中的神经发育结果，解决了叶酸，鱼/脂肪酸和其他的作用 饮食因素可能在缓解神经发育诊断及其的空气污染关联及其 相关的定量性状（ASD，ID和ADHD）； 2）评估青少年的多域健康轨迹 跨回声数据中的神经发育结果，并确定阳性轨迹的预测指标 和结果。使用通过回声努力收集的独特纵向数据，我们将检查轨迹 在精神和身体健康中，研究这些在神经发育诊断的跨性别以及 特质。我们还将寻求进一步描述我们的专业成果领域，以及 自闭症特别是通过进行维度测量的心理测量分析。最后，我们将3）最大化 通过实施回声协议招募和保留我们的队列参与者。我们将 实施由激励措施制定的统一招聘和保留策略和支持网络 具有神经发育状况，过渡年龄的青年及其家人的青少年。团队会 首次对令人印象深刻的年轻人兄弟姐妹的纵向研究随后从子宫到成年。在 这样做，我们的项目提供了独特的机会，以提高对环境预测变量的了解 修饰符，进行神经发育障碍及其潜在特征的盘次比较， 表征多域轨迹，并确定加速量的积极结果的预测因素，并确定 实施回声2阶段协议，以确保在这一重要的 人口，最终，为加速的个人及其家人优化结果。