Prenatal exposure to phthalates and associations with gestational weight gain and fetal growth trajectories.

产前接触邻苯二甲酸盐以及与妊娠体重增加和胎儿生长轨迹的关系。

• 批准号: 10746946
• 负责人: Shabnaz Siddiq
• 金额: $ 4.77万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746946
• 关键词: Asian; Biological Process; Biometry; Birth Weight; Black race; Body Weight; Chemicals; Classification; Complex Mixtures; Data; Development; Disparity; Education; Endocrine; Endocrine Disruptors; Ensure; Environment; Environmental Exposure; Epidemiology; Epigenetic Process; Equation; Ethnic Origin; Ethnic Population; Exposure to; Failure; Fetal Development; Fetal Growth; General Population; Genetic; Goals; Gonadal Steroid Hormones; Growth; Health; Hispanic; Hormonal; Immunity; Individual; Intervention; Kilogram; Knowledge; Life Cycle Stages; Literature; Longevity; Maternal and Child Health; Measures; Metabolism; Methodology; Methods; Mission; Modeling; Modification; Mothers; National Institute of Environmental Health Sciences; Nested Case-Control Study; Not Hispanic or Latino; Nulliparity; Outcome; Oxidative Stress; Participant; Pattern; Placenta; Placentation; Plastics; Policies; Population Heterogeneity; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Pregnant Women; Process; Productivity; Proxy; Race; Regulation; Reproduction; Research; Research Personnel; Research Proposals; Risk; Socioeconomic Factors; Specific qualifier value; Statistical Methods; Sum; Testing; Time; Training; United States; Universities; Woman; Work; advanced analytics; analytical method; career; cohort; critical period; environmental agent; environmental chemical; ethnic disparity; fetal; flexibility; gestational weight gain; glucose metabolism; healthy pregnancy; innovation; insulin sensitivity; lipid metabolism; maternal obesity; maternal outcome; maternal weight; obesity in children; personal care products; phthalates; pregnant; prenatal; prenatal exposure; racial disparity; racial diversity; racial population; sex; skills; theories; therapy design; urinary; Asian; Biological Process; Biometry; Birth Weight; Black race; Body Weight; Chemicals; Classification; Complex Mixtures; Data; Development; Disparity; Education; Endocrine; Endocrine Disruptors; Ensure; Environment; Environmental Exposure; Epidemiology; Epigenetic Process; Equation; Ethnic Origin; Ethnic Population; Exposure to; Failure; Fetal Development; Fetal Growth; General Population; Genetic; Goals; Gonadal Steroid Hormones; Growth; Health; Hispanic; Hormonal; Immunity; Individual; Intervention; Kilogram; Knowledge; Life Cycle Stages; Literature; Longevity; Maternal and Child Health; Measures; Metabolism; Methodology; Methods; Mission; Modeling; Modification; Mothers; National Institute of Environmental Health Sciences; Nested Case-Control Study; Not Hispanic or Latino; Nulliparity; Outcome; Oxidative Stress; Participant; Pattern; Placenta; Placentation; Plastics; Policies; Population Heterogeneity; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Pregnant Women; Process; Productivity; Proxy; Race; Regulation; Reproduction; Research; Research Personnel; Research Proposals; Risk; Socioeconomic Factors; Specific qualifier value; Statistical Methods; Sum; Testing; Time; Training; United States; Universities; Woman; Work; advanced analytics; analytical method; career; cohort; critical period; environmental agent; environmental chemical; ethnic disparity; fetal; flexibility; gestational weight gain; glucose metabolism; healthy pregnancy; innovation; insulin sensitivity; lipid metabolism; maternal obesity; maternal outcome; maternal weight; obesity in children; personal care products; phthalates; pregnant; prenatal; prenatal exposure; racial disparity; racial diversity; racial population; sex; skills; theories; therapy design; urinary

PROJECT SUMMARY/ABSTRACT Widespread exposure to ubiquitous endocrine disrupting chemicals, such as phthalates, during pregnancy, a sensitive period in the life course for both mother and baby, is of global concern. Phthalates and their metabolites (PMs) are associated with increased oxidative stress, hormonal disturbances and epigenetic changes that may interfere with maternal gestational weight gain (GWG) and fetal growth patterns. Maternal GWG and fetal growth rates are important as they influence both short and long-term health outcomes of the mother and baby. Further, pregnancy related racial and ethnic disparities in pregnancy outcomes have persisted over time and environmental exposures may contribute to these. Non-Hispanic Black, Hispanic and Asian women have higher concentrations of PMs likely due to the use of specific personal care products. Although several studies have evaluated PM’s effect on birthweight (the end point of fetal growth) or on periods of GWG, few have considered associations between PMs and fetal growth and GWG rates and those that have are subject to methodological limitations. In addition, there is scarcity of evidence regarding associations between mixtures of PMs and adverse health outcomes. Using data from a nested case control study in a racially diverse population (Nulliparous Mothers To Be (nuMoM2b)), and specifically among healthy controls, we will explore associations between PMs and GWG and fetal growth trajectories using sophisticated statistical methods (i.e., growth mixture models, generalized estimating equations and weighted quantile sum regression) which account for multiple measures of both exposures and outcomes, and account for PM mixtures. We propose the following aims: 1) to examine associations between prenatal exposure to PMs (and their mixtures), measured in each pregnancy trimester and a) GWG and b) estimated fetal growth trajectories among 960 healthy pregnant women across the United States; 2) to evaluate modification by race/ethnicity and fetal-sex between PMs and GWG and fetal growth. This will be the first study to evaluate the effect of a ubiquitous environmental exposure on GWG and fetal growth trajectories. Findings from the proposed study are important to identify critical windows of gestation when maternal GWG and fetal growth may be more be more sensitive to insults from PMs. Importantly, this will aid the design of interventions to reduce phthalate exposure levels, inform policies to regulate phthalate concentrations in products, and educate and target women at greatest risk of exposure. Execution of these specific aims will advance NIEHS’s mission to understand the impact of a ubiquitous environmental exposure, phthalates, on salient maternal fetal outcomes. The proposed training plan will be delivered within Columbia University, one of the world’s preeminent research universities, providing skills in environmental exposures including mixtures analysis, maternal child health and advanced analytic methods that will, with the support of an excellent sponsor team, will ensure successful completion of the study aims and prepare me to a career as an independent productive researcher.

项目摘要/摘要 在怀孕期间，普遍暴露于无处不在的内分泌化学物质（例如邻苯二甲酸盐） 母亲和婴儿的生活课程敏感时期引起了全球关注。邻苯二甲酸盐及其 代谢物（PMS）与氧化应激，激素障碍和表观遗传学有关 可能会干扰物物妊娠体重增加（GWG）和胎儿生长模式的变化。母亲 GWG和胎儿生长率很重要，因为它们影响了短期和长期健康结果 母亲和婴儿。此外，怀孕结局中的与孕妇有关的种族和种族分布 随着时间的流逝，环境暴露可能会导致这些。非西班牙裔黑人，西班牙裔和 亚洲妇女的PM浓度较高，可能是由于使用了特定的个人护理产品。 尽管几项研究评估了PM对出生体重的影响（胎儿生长的终点）或时期 在GWG中，很少有人考虑PMS与胎儿生长与GWG率之间的关联以及 受到方法论上的局限性。此外，关于关联的证据很少 在PM的混合物和不良健康结果之间。使用来自嵌套案例控制研究的数据 种族多样化的人群（无效母亲为（NUMOM2B）），特别是在健康对照中， 我们将使用复杂的统计数据探索PMS和GWG与胎儿生长轨迹之间的关联 方法（即生长混合模型，广义估计方程和加权分位数总和回归） 这是对暴露和结果的多种量度，并解释了PM混合物。我们 提案以下目的：1）检查产前暴露与PMS的关联（及其 混合物），在每个怀孕三个月和a）GWG和b）估计胎儿生长轨迹 在美国的960名健康孕妇中； 2）通过种族/种族和种族和 PMS和GWG和胎儿生长之间的胎儿性质。这将是评估A的效果的第一项研究 GWG和胎儿生长轨迹的无处不在环境暴露。拟议研究的发现 当Mater GWG和胎儿生长可能更重要时，要确定关键的妊娠窗户很重要 对PMS的侮辱更敏感。重要的是，这将有助于设计干预措施以减少邻苯二甲酸酯 暴露水平，告知政策以调节产品中的邻苯二甲酸盐浓度，并教育和目标 妇女面临最大的风险。执行这些特定目标将使Niehs的使命 了解无处不在的环境暴露，邻苯二甲酸盐对显着物质胎儿结局的影响。 拟议的培训计划将在哥伦比亚大学（Columbia University）内交付，这是世界上最杰出的 研究大学，提供环境暴露技能，包括混合物分析，遗产儿童 健康和高级分析方法将在出色的赞助商团队的支持下，将确保 成功完成研究的目的是为了成为独立产品研究人员的职业。