The Contribution of Chronic Stress and Psychosocial Resources on Aging in Young and Early Midlife Black Women

慢性压力和心理社会资源对年轻和中年早期黑人女性衰老的贡献

• 批准号: 10740488
• 负责人: Telisa Spikes
• 金额: $ 16.34万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10740488
• 关键词: Acceleration; Adult; Adverse effects; Age; Aging; Biological; Biological Aging; Biological Assay; Biometry; Black race; Blood Vessels; Buffers; Cardiovascular Diseases; Chronic stress; Chronology; Creativeness; Cross-Sectional Studies; Data; Disease; Disparity; Education; Environment; Estrogens; Exhibits; Exposure to; Femur; Fostering; Functional disorder; Gender; Goals; Health; Heart; High Prevalence; Hypertension; Immune system; Income; Inflammation; Inflammatory; Interview; Knowledge; Left Ventricular Hypertrophy; Life; Life Cycle Stages; Linear Regressions; Link; Longitudinal cohort; Measurement; Measures; Mediating; Mentored Patient-Oriented Research Career Development Award; Methods; Morbidity - disease rate; National Institute of Nursing Research; Occupations; Organ; Organism; Outcome; Outcome Study; Pathogenicity; Pathway interactions; Pattern; Perception; Personal Satisfaction; Persons; Physiologic pulse; Physiological; Predisposition; Prevalence; Process; Production; Proliferating; Proxy; Psychoneuroimmunology; Qualitative Methods; Race; Research; Research Methodology; Resources; Risk; Risk Factors; Role; Social Environment; Social Network; Social isolation; Socioeconomic Status; Source; Stress; Structure; Subgroup; Sum; Time; Training; Training Activity; United States; Venous blood sampling; Vulnerable Populations; Weather; Woman; age related; aged; arterial stiffness; black men; black women; cardioprotection; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cohort; cytokine; design; early onset; experience; health equity; health equity promotion; heart disease risk; high risk; immunoregulation; indexing; lens; low socioeconomic status; men; middle age; mortality; mortality risk; outcome disparities; perceived stress; physical conditioning; predictive marker; psychosocial resources; resilience; response; skill acquisition; skills; social; social disparities; social health determinants; socioeconomics; standard measure; stress reduction; stressor; theories

Project Abstract In the United States, Black men and women develop hypertension (HTN) at younger ages and have the highest prevalence, 58% and 57%, compared to aged-matched White men and women 51% and 41%. Early onset HTN among early midlife Black women (BW) 35-44 years old is also linked to a higher burden of HTN- mediated organ damage and cardiovascular disease (CVD) morbidity and mortality. The exact cause of these disparate outcomes remains unknown but may be due to a greater burden of distinct stressors, i.e., racial, gender, financial, job, and social network, experienced by BW regardless of socioeconomic position (SEP), causing weathering and accelerated biological aging. The impact of social and environmentally influenced stressors are theorized to override the cardioprotective effects of endogenous estrogen in BW and may also underlie a key mechanism linking stress to acceleration of the aging process and poor cardiovascular health in this subgroup. Chronic stress is considered a potent risk factor of accelerated aging and age-related diseases, while aging is considered a potent risk factor of CVD and is linked with arterial stiffness, a predictive marker of subclinical CVD and mortality risk. Mounting evidence suggests that moderating resources such as resilience, the process or outcome of successful adaptation despite adversity, may modify the relationship between chronic stress and aging. Yet, resilience may not be uniformly beneficial and may enhance the adverse effects of stress. Aligned with the National Institute of Nursing Research high-priority focus on social determinants of health with an emphasis on the embodiment of social inequalities and health equity, the K23 training aims of this mixed-method cross sectional study of n=85 BW are: 1) Examine the associations between chronic stress burden (CSB) overall and each stressor separately on biologic age (BA) and carotid femoral pulse wave velocity (cf-PWV) stratified by socioeconomic position (SEP); 2) Examine the effects of SEP and resilience on BA and cf-PWV and whether resilience modifies the effect between CSB and BA, as well as arterial stiffness 3) Describe perceived sources of CSB and how they influence resilience using semi-structured interviews with a subsample of 18 women consisting of the highest (n=9) and lowest (n=9) combined tertiles for BA and cf-PWV. Specific training activities during the K23 award are to obtain: 1) expertise in psychoneuroimmunology, stress, and health; 2) conduct and interpret cf-PWV measurements; 3) Phlebotomy, lab assay processing and storage; 4) proficiency and acquisition of skills in mixed-methodology research; 5) conduct advanced biostatistical linear regression methods to measure biological aging. My long-term goal is to apply the knowledge and skills obtained under this K23 to establish a longitudinal cohort examining the role of SEP, chronic stress, and health protective resources that may enhance or mitigate physiologic dysregulation and CVD risk over time.

项目摘要 在美国，黑人男女在年轻时发展高血压（HTN），并拥有 最高患病率，58％和57％，而老年人匹配的白人男女为51％和41％。早期的 早期中年黑人妇女（BW）35-44岁的发作HTN也与HTN-的更高负担有关 介导的器官损伤和心血管疾病（CVD）发病率和死亡率。这些的确切原因 不同的结果仍然未知，但可能是由于更大的压力源负担，即种族， BW经历的性别，财务，工作和社交网络，无论社会经济地位如何（SEP）， 引起风化和加速生物衰老。社会和环境影响的影响 理论上认为应力源以覆盖内源性雌激素在BW中的心脏保护作用，也可能 是关键机制，将压力与衰老过程的加速和不良心血管健康联系起来 这个子组。慢性压力被认为是加速衰老和与年龄有关的疾病的有效危险因素， 虽然衰老被认为是CVD的有效危险因素，并且与动脉刚度有关 亚临床CVD和死亡率风险。越来越多的证据表明，调节资源，例如弹性， 尽管存在逆境，但成功适应的过程或结果可能会改变 慢性压力和衰老。然而，弹性可能不会统一有益，并可能增强不利影响 压力。与国家护理研究所的高优先级重点关注的社会决定因素 K23培训目标的健康重点是对社会不平等和健康公平的体现， n = 85 bw的混合方法横截面研究是：1）检查慢性应激之间的关联 总体负担（CSB）和每个压力源分别在生物年龄（BA）和颈动脉脉搏波上分别 通过社会经济地位（SEP）分层的速度（CF-PWV）； 2）检查SEP和弹性对 BA和CF-PWV以及弹性是否改变了CSB和BA之间的效果，以及动脉刚度3） 描述CSB的感知来源及其如何使用半结构化访谈来影响韧性 由BA和CF-PWV组成的18名女性的子样本，由最高（n = 9）和最低（n = 9）组合组成。 K23奖期间的特定培训活动将获得：1）心理肌免疫学，压力， 和健康； 2）进行和解释CF-PWV测量； 3）静脉切开术，实验室分析加工和存储； 4）混合方法研究中的技能熟练和获取； 5）进行晚期生物统计线性 测量生物衰老的回归方法。我的长期目标是运用知识和技能 在此K23下获得的纵向队列，研究了SEP，慢性应激和健康的作用 随着时间的流逝，可以增强或减轻生理失调和CVD风险的保护资源。