Effects of a behavioral sleep extension intervention on cardiometabolic risk factors among patients with elevated BP/hypertension

行为睡眠延长干预对血压升高/高血压患者心脏代谢危险因素的影响

• 批准号: 10627801
• 负责人: Kelly Glazer Baron
• 金额: $ 57.58万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-25 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627801
• 关键词: Acute; Adult; Ambulatory Blood Pressure Monitoring; American; Area; Attention; Behavior; Behavior Therapy; Behavioral; Behavioral Model; Biological; Biological Markers; Blood Pressure; Body fat; Body mass index; Cardiometabolic Disease; Cardiovascular system; Cessation of life; Chronic Disease; Clinical; Cognitive Therapy; Control Groups; Coronary heart disease; Desire for food; Development; Diabetes Mellitus; Diet; Disease Management; Drowsiness; Education; Electronic Mail; Evaluation; Goals; Health; Health behavior; Health education; Heart Diseases; Hypertension; Inflammation; Intervention; Knowledge; Life; Life Style; Link; Lipids; Maintenance; Measures; Mediator; Metabolic; Monitor; Motivation; Outcome Study; Participant; Pathway interactions; Patient Outcomes Assessments; Patient Self-Report; Patients; Pattern; Personal Satisfaction; Phase; Physical activity; Physiological; Population; Quality of life; Randomized, Controlled Trials; Research; Risk Factors; Sample Size; Sleep; Sleep Deprivation; Sleep Disorders; Stroke; Sympathetic Nervous System; Testing; Time; Unhealthy Diet; attenuation; behavior change; blood pressure elevation; cardiometabolic risk; cardiometabolism; clinically significant; comparison control; comparison intervention; design; diet and exercise; disorder risk; efficacy evaluation; efficacy testing; experimental group; experimental study; follow-up; glycemic control; group intervention; improved; insulin sensitivity; intervention effect; motivational enhancement therapy; pilot test; prehypertension; primary outcome; programs; psychologic; public health relevance; secondary outcome; sleep quality; telephone coaching; theories; therapy development; wearable device

PROJECT SUMMARY/ABSTRACT One in two adults in the U.S. have at least one cardiometabolic disease (CMD) including hypertension, heart disease diabetes or stroke. Despite links between short sleep duration and cardiometabolic health, few studies have sought to improve CMD risk by extending sleep. A promising area of research is sleep extension interventions. To date, several small studies have demonstrated short term improvements in sleep and CMD risk factors such as blood pressure and glycemic control. However, these studies are limited by their short term design and viewing sleep extension as an experimental manipulation rather than a sustainable behavior change. In this study, we are proposing to conduct a randomized controlled trial to test our behavioral sleep extension intervention compared to a health education control group on sleep and CMD risk factors among adults with prehypertension/stage I hypertension. The sleep extension intervention is based on 3 well established behavior change principles: self-monitoring (wearable sleep tracker), education (email content) and motivational enhancement (brief telephone coaching). During this 12 month study, we will include an intervention period (weeks 1-8, weekly intervention), maintenance period (months 2-6, monthly intervention) and follow-up period (no intervention). The primary outcome for this study will be sleep duration and the main secondary outcome will be 24-h ambulatory blood pressure monitoring, which allows us to evaluate both daytime and nighttime blood pressures in daily life. The evaluation of sleep duration changes of 12-months will allow us to test the efficacy of our behavioral sleep extension intervention on acute and sustained changes in sleep duration and CMD risk factors as well as important psychological, behavioral and physiological mediators such as self-reported sleepiness, BMI, diet, physical activity, glycemic control and inflammation. Successful completion of this study will provide critical information about the impact of behavioral sleep extension on important measures of health and quality of life needed to incorporate sleep extension into CMD risk interventions, such as diet and physical activity programs. The long-term goal of this research is to develop, test and disseminate effective and scalable sleep interventions to reduce chronic disease risk and improve disease management.

项目概要/摘要 美国有二分之一的成年人至少患有一种心脏代谢疾病 (CMD)，包括高血压、心脏病 疾病 糖尿病或中风。尽管睡眠时间短与心脏代谢健康之间存在联系，但很少有人 研究试图通过延长睡眠来降低 CMD 风险。一个有前景的研究领域是延长睡眠 干预措施。迄今为止，几项小型研究已证明睡眠和 CMD 的短期改善 血压和血糖控制等危险因素。然而，这些研究因其时间短而受到限制 术语设计并将睡眠延长视为一种实验性操作而不是一种可持续行为 改变。在这项研究中，我们建议进行一项随机对照试验来测试我们的行为睡眠 与健康教育对照组相比，扩展干预对睡眠和 CMD 危险因素的影响 患有高血压前期/I期高血压的成人。睡眠延长干预基于 3 个良好的 既定的行为改变原则：自我监控（可穿戴睡眠追踪器）、教育（电子邮件内容） 和激励增强（简短的电话辅导）。在这 12 个月的研究中，我们将包括 干预期（第1-8周，每周干预），维持期（第2-6个月，每月干预） 和随访期（无干预）。这项研究的主要结果是睡眠持续时间和主要结果 次要结果是 24 小时动态血压监测，这使我们能够评估 日常生活中的白天和夜间血压。 12个月睡眠时间变化评估 将使我们能够测试行为睡眠延长干预对急性和持续性睡眠的有效性 睡眠时间和 CMD 危险因素的变化以及重要的心理、行为和 生理调节因素，如自我报告的困倦、BMI、饮食、体力活动、血糖控制和 炎。成功完成这项研究将提供有关影响的重要信息 行为睡眠延长是衡量健康和生活质量的重要指标，需要将睡眠纳入其中 扩展到 CMD 风险干预措施，例如饮食和身体活动计划。本次活动的长远目标 研究的目的是开发、测试和传播有效且可扩展的睡眠干预措施，以减少慢性睡眠障碍 疾病风险并改善疾病管理。