Core A - Administration

核心 A - 管理

• 批准号: 10628926
• 负责人: Francesca M Marassi
• 金额: $ 14.55万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628926
• 关键词: Advisory Committees; Age related macular degeneration; Aging; Alzheimer' s Disease; Animals; Area; Automobile Driving; Biochemistry; Biological; Cellular biology; Collaborations; Disease; Disease Progression; Ensure; Etiology; Functional disorder; Goals; Hydroxyapatites; Individual; Institution; Laboratories; Lipids; Medical; Mentors; Molecular; Pathology; Persons; Physiology; Process; Proteins; Research; Research Personnel; Role; Structure; Training; age related; calcification; calcium phosphate; insight; interdisciplinary approach; meetings; mineralization; multidisciplinary; programs; structural biology; success; web site

CORE A SUMMARY Administrative Core. The overall goal of this Program Project is to elucidate the biological mechanisms of ectopic calcification and its roles in the onset and etiology of diseases of aging, with particular focus on age- related macular degeneration (AMD) and Alzheimer’s disease (AD). The major components of ectopic calcifications are proteins, lipids and mineralized calcium phosphate, especially hydroxyapatite (HAP) and whitlockite (WHT), but the roles of these components in the calcification process and disease progression are not known. Four Projects and one technical Core will collaborate to gain a comprehensive mechanistic view of ectopic calcification in age-related pathologies. Achieving this goal requires an integrated multidisciplinary approach that combines multi-scale structural biology, biochemistry, cell biology and animal physiology, guided by experts in these specific areas. The principal role of the Administrative Core is to ensure the success of the Program as an integrated multidisciplinary and multi-scale investigative effort, and generate a comprehensive view of calcification in diseases of aging that could not achieved by individual laboratories working alone. This is essential for gaining comprehensive biomedical insights. To support this goal, the Core will facilitate interactions among the investigators and provide a strong administrative structure.

核心总结 该计划项目的总体目标是阐明其生物学机制。 异位钙化及其在衰老疾病的发病和病因学中的作用，特别关注年龄- 相关黄斑变性（AMD）和阿尔茨海默氏病（AD）的主要组成部分。 钙化物是蛋白质、脂质和矿化磷酸钙，特别是羟基磷灰石（HAP）和 白铁矿（WHT），但这些成分在钙化过程和疾病进展中的作用是 四个项目和一个技术核心将合作以获得全面的机械视图。 与年龄相关的病理学中的异位钙化的实现需要综合的多学科。 结合多尺度结构生物学、生物化学、细胞生物学和动物生理学的方法，引导 行政核心的主要作用是确保这些特定领域的专家的成功。 该计划作为一项综合的多学科和多规模的调查工作，并产生全面的 衰老疾病中钙化的观点是单个实验室无法单独实现的。 对于获得全面的生物医学见解至关重要，为了支持这一目标，核心将促进。 调查人员之间的互动并提供强有力的管理结构。