The Iowa Neuroscience Specialty Program in Research Education (INSPIRE)

爱荷华州神经科学研究教育专业计划（INSPIRE）

• 批准号: 10627477
• 负责人: HANNA E STEVENS
• 金额: $ 23.27万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627477
• 关键词: Iowa; Neurosciences; education research; medical specialties; programs

This application requests continuation of funding for a successful and long-standing training program (dating back to 1991). This program was rebranded 5 years ago as the Iowa Neuroscience Specialty Program In Research Education (INSPIRE) to integrate training in Translational Neuroscience relevant to psychiatry with an emphasis on a lifespan trajectory perspective. Research opportunities are unified through a focus on the critical framework for Translational Neuroscience, the NIMH’s Research Domain Criteria (RDoC) project which focuses on mechanisms of psychopathology within functional dimensions rather than diagnostic criteria. INSPIRE is now training young investigators who have a high level of sophistication in thinking about and interrogating the complexities of the human brain’s functional domains, the change of these systems over time, and how discovery of mechanisms of pathologic functioning are translated to clinical diagnosis and treatment. The Co-PIs are Peg Nopoulos, an alumnus of this T32 program herself and a national leader in research training and neuroimaging, and John Wemmie, a translational psychiatry investigator with long-term federal research funding across multiple domains. The Co-PIs have retained the solid foundation of this program put in place by Nancy Andreasen, a pioneer in neuroimaging and psychosis. The reframed program started 5 years ago has two core areas: 1) a highly structured curriculum emphasizing Translational Neuroscience, and 2) a focus on the study of neurobiologic mechanisms of psychiatric illness across the lifespan. The content of the program expanded into multiple areas of Translational Neuroscience by partnering with the Molecular and Computational Psychiatry division and the Iowa Neuroscience Institute (INI). MD/PhD and PhD mentors with strong training records are newly recruited to the program due to a focus on Translational Neuroscience or through recent INI recruitment. Accordingly, the program has a diverse, interdisciplinary group of trainees with basic science PhDs, MDs, and MD/PhDs all building a Translational Neuroscience identity. Matching funds that support additional trainees help to form a cohesive cohort. This mix of types of trainees adds an additional layer of exposure to translational research with a strong emphasis on team science. Central to the training is the Master’s in Translational Biomedicine (TBM) program through our Institute for Clinical and Translational Sciences (ICTS). This program is designed to be individualized and flexible. The INSPIRE program recruits fellows to fill 4 positions each year for two years of postdoctoral training. Each fellow is ‘matched’ with an outstanding mentor and mentor team to oversee the primary activity of mentored research. A weekly seminar encompasses essential skills including presenting, writing, and networking with faculty in Translational Neuroscience. In addition, each fellow develops a program through the TBM that suits their needs while fulfilling requirements (such as Training in Responsible Conduct in Research), utilizing formal didactics and career development activities. A degree (certificate or Master’s) is an option, but not required.

该申请要求继续为成功和长期培训计划提供资金 （可追溯到1991年）。该计划于5年前作为爱荷华州神经科学专业计划更名 在研究教育（INSPIRE）中纳入与精神病学相关的转化神经科学培训 重点是寿命轨迹的观点。研究机会是通过关注 NIMH的研究领域标准（RDOC）项目的转化神经科学的关键框架 它的重点是功能维度内的心理病理学机制，而不是诊断标准。 Inspire现在正在培训年轻的调查员，他们在思考和 询问人脑功能领域的复杂性，随着时间的推移这些系统的变化， 以及如何发现病理功能机制的发现如何转化为临床诊断和治疗。 Co-Pis是Peg Nopoulos，这是该T32计划本身的校友，也是研究的国家领导者 培训和神经影像学，以及长期联邦的转化精神病学调查员约翰·韦米（John Wemmie） 研究跨多个领域的资金。 Co-Pis保留了该计划的坚实基础 神经影像和精神病的先驱南希·安德里亚森（Nancy Andreasen）的位置。改进计划开始了5年 AGO有两个核心领域：1）强调翻译神经科学的高度结构化课程，以及2） 专注于整个生命周期的精神病的神经生物学机制。 该程序的内容通过与 分子和计算精神病学部以及爱荷华州神经科学研究所（INI）。 MD/PHD和 具有强大培训记录的博士学位导师新招募到该计划，因为专注于翻译 神经科学或通过最近的INI招聘。根据该计划的潜水员，跨学科小组 拥有基础科学博士，MDS和MD/PHD的学员的众多，都建立了转化神经科学的身份。 支持其他学员的匹配资金有助于形成一个凝聚力的队列。这种类型的学员 在转化研究中增加了一层趋势，重点是团队科学。 培训的核心是通过我们的研究所的转化生物医学硕士（TBM）计划 临床和转化科学（ICT）。该程序旨在个性化和灵活。这 激发计划的报告每年在两年的博士后培训中填补4个职位。每个 研究员与杰出的心理和心理团队“匹配”，以监督心理的主要活动 研究。每周的半手赛涵盖了基本技能，包括展示，写作和网络 翻译神经科学的教师。此外，每个人都通过TBM制定一个适合的程序 他们的需求在满足要求（例如研究中负责任的行为培训），使用正式 教学和职业发展活动。学位（证书或硕士学位）是一种选择，但不是必需的。

项目成果

Modeling Human Cerebellar Development In Vitro in 2D Structure.

• DOI: 10.3791/64462
• 发表时间: 2022-09-16
• 期刊: Journal of visualized experiments : JoVE
• 作者: Madencioglu DA;Kruth KA;Wassink TH;Magnotta VA;Wemmie JA;Williams AJ
• 通讯作者: Williams AJ

Aging, grey matter, and blood flow in the anterior cingulate cortex.

衰老、灰质和前扣带皮层的血流。

• DOI: 10.1016/j.neuroimage.2007.06.015
• 发表时间: 2007
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Vaidya,JatinG;Paradiso,Sergio;BolesPonto,LauraL;McCormick,LaurieM;Robinson,RobertG
• 通讯作者: Robinson,RobertG

Multi-shot sensitivity-encoded diffusion data recovery using structured low-rank matrix completion (MUSSELS).

• DOI: 10.1002/mrm.26382
• 发表时间: 2017-08
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Mani M;Jacob M;Kelley D;Magnotta V
• 通讯作者: Magnotta V

Comprehensive reconstruction of multi-shot multi-channel diffusion data using mussels.

利用贻贝对多镜头多通道扩散数据进行综合重建。

• DOI: 10.1109/embc.2016.7590897
• 发表时间: 2016
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Mani,Merry;Magnotta,Vincent;Kelley,Douglas;Jacob,Mathews
• 通讯作者: Jacob,Mathews

Failure to breathe persists without air hunger or alarm following amygdala seizures.

• DOI: 10.1172/jci.insight.172423
• 发表时间: 2023-11-22
• 期刊: JCI INSIGHT
• 影响因子: 8
• 作者: Harmata, Gail I. S.;Rhone, Ariane E.;Kovach, Christopher K.;Kumar, Sukhbinder;Mowla, Md Rakibul;Sainju, Rup K.;Nagahama, Yasunori;Oya, Hiroyuki;Gehlbach, Brian K.;Ciliberto, Michael A.;Mueller, Rashmi N.;Kawasaki, Hiroto;Pattinson, Kyle T. S.;Simonyan, Kristina;Davenport, Paul W.;Howard III, Matthew A.;Steinschneider, Mitchell;Chan, Aubrey C.;Richerson, George B.;Wemmie, John A.;Dlouhy, Brian J.
• 通讯作者: Dlouhy, Brian J.