B-NET Administrative Supplement

B-NET行政补充

• 批准号: 10631298
• 负责人: STEPHEN B. KRITCHEVSKY
• 金额: $ 36.65万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10631298
• 关键词: Address; Administrative Supplement; Affect; Age; Brain; Brain region; Characteristics; Communities; Elderly; Magnetic Resonance Imaging; Measures; Movement; Physical Performance; Quality of life; Role; Science; Structure; age related; aging brain; base; cohort; imaging approach; innovation; novel strategies; prevent; societal costs; white matter

Project Summary/Abstract Declining mobility function is a common age-related phenomenon that is associated with reduced quality of life and high societal costs. Recently, the brain's critical role in mobility function has been recognized using imaging approaches assessing white matter characteristics. A new paradigm considering the brain as acomplex network uses MRI-based approaches to directly characterize the brain as a functional network. Brain Networks and Mobility Function: B-NET brings together national leaders in brain network science and mobility assessment to apply this innovative network paradigm to elucidate the brain's role in declining mobility. We propose that changes in functional connectivity within and between brain regions supporting movement predict declining mobility. We hypothesize that age-related structural damage affects mobility, in part, by degrading the community structure of sensorimotor cortex (SMC) reflected in lower SMC modularity and increased SMC connectivity to other brain regions. B-Net established a cohort of 192 community-dwelling older adults (age range 70-85) and measure mobility function at baseline, 6, 18 and 30 months using the extended short physical performance battery (eSPPB) to address the following specific aims.

项目概要/摘要 行动功能下降是一种常见的与年龄相关的现象，与 生活质量下降和社会成本高昂。最近，大脑在移动性中发挥着关键作用 功能已通过评估白质特征的成像方法来识别。 一种将大脑视为复杂网络的新范式使用基于 MRI 的方法来 直接将大脑表征为一个功能网络。大脑网络和移动功能： B-NET 汇集了脑网络科学和移动评估领域的国家领导者 应用这种创新的网络范例来阐明大脑在活动能力下降中的作用。我们 提出大脑区域内部和之间功能连接的变化支持 运动预示着流动性下降。我们假设与年龄相关的结构损伤会影响 移动性部分是通过降低感觉运动皮层（SMC）的群落结构来体现的 降低 SMC 模块化并增加 SMC 与其他大脑区域的连接。 B-Net 建立了一个由 192 名社区老年人（年龄范围 70-85 岁）组成的队列， 使用延长的短期体能测量基线、6、18 和 30 个月时的活动功能 高性能电池（eSPPB）来解决以下特定目标。

项目成果

Associations of physical function and body mass index with functional brain networks in community-dwelling older adults.

社区老年人的身体功能和体重指数与功能性大脑网络的关联。

• DOI: 10.1016/j.neurobiolaging.2023.03.008
• 发表时间: 2023
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Laurienti,PaulJ;Miller,MichaelE;Lyday,RobertG;Boyd,MadelineC;Tanase,AlexisD;Burdette,JonathanH;Hugenschmidt,ChristinaE;Rejeski,WJack;Simpson,SeanL;Baker,LauraD;Tomlinson,ChalE;Kritchevsky,StephenB
• 通讯作者: Kritchevsky,StephenB

Frontal Atrophy and Executive Dysfunction Relate to Complex Numbers Impairment in Progressive Supranuclear Palsy.

• DOI: 10.3233/jad-215327
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Howard, Erica;Ballinger, Samantha;Kinney, Nikolas G.;Balgenorth, Yvonne;Ehrhardt, Annabess;Phillips, Jeffrey S.;Irwin, David J.;Grossman, Murray;Cousins, Katheryn A. Q.
• 通讯作者: Cousins, Katheryn A. Q.

Corrigendum: Examining the intersection of cognitive and physical function measures: Results from the brain networks and mobility (B-NET) study.

• DOI: 10.3389/fnagi.2023.1166863
• 发表时间: 2023
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8

Effects of a Motor Imagery Task on Functional Brain Network Community Structure in Older Adults: Data from the Brain Networks and Mobility Function (B-NET) Study.

• DOI: 10.3390/brainsci11010118
• 发表时间: 2021-01-17
• 期刊: Brain sciences
• 影响因子: 3.3
• 作者: Neyland BR;Hugenschmidt CE;Lyday RG;Burdette JH;Baker LD;Rejeski WJ;Miller ME;Kritchevsky SB;Laurienti PJ
• 通讯作者: Laurienti PJ