B-NET Administrative Supplement

B-NET行政补充

• 批准号: 10631298
• 负责人: STEPHEN B. KRITCHEVSKY
• 金额: $ 36.65万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10631298
• 关键词: Address; Administrative Supplement; Affect; Age; Brain; Brain region; Characteristics; Communities; Elderly; Magnetic Resonance Imaging; Measures; Movement; Physical Performance; Quality of life; Role; Science; Structure; age related; aging brain; base; cohort; imaging approach; innovation; novel strategies; prevent; societal costs; white matter

Project Summary/Abstract Declining mobility function is a common age-related phenomenon that is associated with reduced quality of life and high societal costs. Recently, the brain's critical role in mobility function has been recognized using imaging approaches assessing white matter characteristics. A new paradigm considering the brain as acomplex network uses MRI-based approaches to directly characterize the brain as a functional network. Brain Networks and Mobility Function: B-NET brings together national leaders in brain network science and mobility assessment to apply this innovative network paradigm to elucidate the brain's role in declining mobility. We propose that changes in functional connectivity within and between brain regions supporting movement predict declining mobility. We hypothesize that age-related structural damage affects mobility, in part, by degrading the community structure of sensorimotor cortex (SMC) reflected in lower SMC modularity and increased SMC connectivity to other brain regions. B-Net established a cohort of 192 community-dwelling older adults (age range 70-85) and measure mobility function at baseline, 6, 18 and 30 months using the extended short physical performance battery (eSPPB) to address the following specific aims.

项目摘要/摘要 迁移率下降是与年龄相关的常见现象，与 减少生活质量和高昂的社会成本。最近，大脑在流动性中的关键作用 使用评估白质特征的成像方法识别功能。 考虑到大脑作为Acomplex网络使用基于MRI的方法，一种新的范式 直接将大脑描述为功能网络。大脑网络和移动功能： B-NET将脑网络科学领域的国家领导者汇集到 应用这种创新的网络范式来阐明大脑在减少移动性中的作用。我们 提出，大脑区域内和支持支持的功能连通性的变化 运动预测流动性下降。我们假设与年龄相关的结构损害影响 在某种程度上，移动性通过降低反射的感觉运动皮层（SMC）的社区结构 降低SMC模块性并增加了与其他大脑区域的SMC连接性。 B-NET建立了192个社区居住的老年人（年龄范围70-85）和 使用延长的短物理 性能电池（ESPPB）以解决以下特定目标。

项目成果

Associations of physical function and body mass index with functional brain networks in community-dwelling older adults.

社区老年人的身体功能和体重指数与功能性大脑网络的关联。

• DOI: 10.1016/j.neurobiolaging.2023.03.008
• 发表时间: 2023
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Laurienti,PaulJ;Miller,MichaelE;Lyday,RobertG;Boyd,MadelineC;Tanase,AlexisD;Burdette,JonathanH;Hugenschmidt,ChristinaE;Rejeski,WJack;Simpson,SeanL;Baker,LauraD;Tomlinson,ChalE;Kritchevsky,StephenB
• 通讯作者: Kritchevsky,StephenB

Frontal Atrophy and Executive Dysfunction Relate to Complex Numbers Impairment in Progressive Supranuclear Palsy.

• DOI: 10.3233/jad-215327
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Howard, Erica;Ballinger, Samantha;Kinney, Nikolas G.;Balgenorth, Yvonne;Ehrhardt, Annabess;Phillips, Jeffrey S.;Irwin, David J.;Grossman, Murray;Cousins, Katheryn A. Q.
• 通讯作者: Cousins, Katheryn A. Q.

Corrigendum: Examining the intersection of cognitive and physical function measures: Results from the brain networks and mobility (B-NET) study.

• DOI: 10.3389/fnagi.2023.1166863
• 发表时间: 2023
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8

Effects of a Motor Imagery Task on Functional Brain Network Community Structure in Older Adults: Data from the Brain Networks and Mobility Function (B-NET) Study.

• DOI: 10.3390/brainsci11010118
• 发表时间: 2021-01-17
• 期刊: Brain sciences
• 影响因子: 3.3
• 作者: Neyland BR;Hugenschmidt CE;Lyday RG;Burdette JH;Baker LD;Rejeski WJ;Miller ME;Kritchevsky SB;Laurienti PJ
• 通讯作者: Laurienti PJ