Facility Upgrade for the New England Regional Biosafety Laboratory

新英格兰地区生物安全实验室设施升级

• 批准号: 10630474
• 负责人: Sam R Telford
• 金额: $ 383.97万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-22 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630474
• 关键词: Address; Administrative Supplement; Aging; Animal Experimentation; Animal Model; Animals; Automation; Award; Carbon; Cell Culture Techniques; Cell Separation; Cells; Chromium; Communication; Complement; Containment; Decontamination; Emergency Situation; Emerging Communicable Diseases; Ensure; Environment; Failure; Foundations; Future; Grant; Growth; Home; Image; Industry; Infectious Diseases Research; Infrastructure; Institution; Laboratories; Laboratory Research; Lighting; Longevity; Methods; Mission; Modernization; Monitor; New England; Operating System; Output; Power Plants; Power Sources; Process; Research; Research Activity; Research Personnel; Research Support; Resources; Rodent; Safety; Sampling; Secure; Solar Energy; System; Systems Analysis; Technology; Telemetry; Time; Universities; Veterinary Medicine; Veterinary Schools; Virus Diseases; Work; aged; base; biocontainment facility; catalyst; cell growth; cost; design; equipment acquisition; improved; laboratory equipment; programs; remote monitoring; repaired; single cell sequencing; sound; tool; transcriptomics; wasting; water treatment

1. PROJECT SUMMARY (G20) The New England Regional Biosafety Laboratory (NERBL) was established in 2007 on the Tufts University Cummings School of Veterinary Medicine (TUCSVM) North Grafton MA campus. This facility was originally designed to support research on emerging infectious diseases under BSL2 and BSL3 conditions, facilitate animal model ABSL3 studies, and allow local and regional investigators access to biocontainment facilities not available within their home institutions. Over the past 13+ years, the NERBL has effectively served as an important resource for researchers across TU as well as a variety of external stakeholders, including industry sponsors. However, several constraints have begun to hamper growth and sustainability of its mission. These include outdated and/or non-functional laboratory equipment, poor efficiencies and workflow in the vivarium spaces, and aging building systems that represent safety and operational concerns. As such, the central purpose of this application is to upgrade our existing facility, particularly its foundational operating systems, and to modernize the vivarium and laboratory spaces with state-of-the-art technologies. To accomplish this, we will: 1) Upgrade the building automation system, HVAC actuators/filters/valves, facility lighting and electrical systems, and communication platforms; 2) Modernize and expand the vivarium with new ventilated rack systems that accommodate disposable caging for small animals to reduce costs and improve efficiencies, purchase a bioBUBBLE containment system to facilitate studies using larger animals, and implement telemetry for remote monitoring of animals; 3) Replace obsolete laboratory equipment with modern counterparts for high throughput in containment, permitting each BSL3 laboratory to be fully equipped and functionally independent, thereby maximizing research output, workflow, and user safety; and 4) Improve critical laboratory safety systems with technology upgrades that provide redundancy for decontamination and waste inactivation. Completion of these specific aims will ensure that the NERBL continues to advance emerging infectious disease research for the next decade. We will expand access for investigators performing cutting-edge studies by leveraging advanced laboratory methods and animal models in a safe, secure, and technologically sound environment.

1. 项目概要（G20） 新英格兰地区生物安全实验室 (NERBL) 于 2007 年在塔夫茨大学成立 卡明斯兽医学院 (TUCSVM) 北格拉夫顿马萨诸塞州校园。这个设施原本是 旨在支持 BSL2 和 BSL3 条件下新发传染病的研究，促进 动物模型 ABSL3 研究，并允许当地和区域研究人员进入生物防护设施 在其所在机构内可用。在过去 13 年多的时间里，NERBL 有效地充当了 是工业大学研究人员以及包括工业界在内的各种外部利益相关者的重要资源 赞助商。然而，一些限制因素已经开始阻碍其使命的发展和可持续性。这些 包括过时和/或不起作用的实验室设备、动物园的效率和工作流程不佳 空间和老化的建筑系统代表安全和运营问题。因此，中央 该应用程序的目的是升级我们现有的设施，特别是其基础运营 系统，并利用最先进的技术对动物园和实验室空间进行现代化改造。到 为了实现这一目标，我们将： 1) 升级楼宇自动化系统、HVAC 执行器/过滤器/阀门、设施 照明和电气系统以及通信平台； 2) 用新的设备对动物园进行现代化改造和扩建 通风架系统，可容纳小动物的一次性笼具，以降低成本并改善 效率，购买生物气泡遏制系统以促进使用较大动物的研究，以及 实施遥测技术以远程监控动物； 3）用现代化的实验室设备替换陈旧的实验室设备 对应的高通量遏制，允许每个 BSL3 实验室配备齐全， 功能独立，从而最大限度地提高研究成果、工作流程和用户安全； 4) 改进 关键实验室安全系统采用技术升级，为净化和消毒提供冗余 废物失活。完成这些具体目标将确保 NERBL 继续前进 未来十年的新兴传染病研究。我们将扩大调查人员的访问范围 通过利用先进的实验室方法和动物模型，以安全、可靠的方式进行尖端研究 技术环境良好。