Cortical Representations of Harmonic and Virtual Pitch in Humans

人类谐波和虚拟音高的皮质表征

基本信息

批准号：
10623255
负责人：
Anahita H Mehta
金额：
$ 24.9万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10623255
关键词：
Acoustics Animal Experimentation Anterior Anterolateral Attention Auditory Auditory Prosthesis Auditory area Auditory system Award Behavior Behavioral Characteristics Cochlear Implants Code Complex Cues Data Development Diffuse Electrophysiology (science)Experimental Designs Frequencies Functional Magnetic Resonance Imaging Goals Hearing Human Illusions Imaging Techniques Individual Judgment Lateral Maps Mentors Modeling Modification Music Myelin Neurons Noise Outcome Perception Peripheral Phase Pitch Perception Play Population Process Property Prosthesis Psychoacoustics Reporting Research Role Series Signal Transduction Speech Speech Perception Stimulus Techniques Testing Training Work anatomic imaging density design experimental study hearing impairment insight neural neural correlate neuroimaging neurophysiology normal hearing novel perceptual organization programs response sound stem theories virtual

项目摘要

1 PROJECT SUMMARY/ABSTRACT 2 Pitch and harmonicity play a defining role in the perception of speech and music, and are crucial for 3 the perceptual organization of sounds in an auditory scene. Listeners with hearing loss, and 4 especially those with cochlear implants, suffer from a striking deficit in pitch perception abilities, as 5 current sound processing strategies are unable to provide robust pitch cues. Despite advances in our 6 understanding of how pitch is perceived, coded, and represented in our auditory system, there are 7 still significant gaps in our basic understanding of how pitch, and especially harmonicity, is 8 represented in the auditory cortex. A better understanding of the neural transformations involved in 9 pitch perception should help in designing more effective neural and acoustic prostheses. The overall 10 goal of the proposed project is to understand the neural representation of pitch and harmonicity and 11 elucidate the role of temporal integration in pitch perception using a combination of behavioral 12 (psychoacoustics), electrophysiology (EEG), and neuroimaging techniques (fMRI). In the mentored 13 K99 phase of this project, the candidate will conduct research on both of these overarching themes. 14 fMRI will be used to investigate what properties of harmonic complex tones are represented in 15 anterior-lateral regions of auditory cortex (Aim 1). Using carefully controlled stimuli, this study should 16 provide strong evidence for whether harmonic tones elicit a stronger response than inharmonic tones 17 in auditory cortex. The candidate will also conduct a series of behavioral experiments using a novel 18 stimulus that produces an illusory virtual pitch percept, to provide empirical data for quantifying the 19 parameters governing temporal integration in the perception of pitch (Aim 2). These behavioral 20 experiments will add crucial understanding of the temporal aspects of pitch perception, which are not 21 taken into account in current pitch perception models. In the R00 phase of the project, the candidate 22 will utilize the techniques and findings of Aims 1 and 2 to study two important aspects of pitch 23 processing and perception. A novel modification of the stimulus investigated in Aim 2 will be utilized in 24 an fMRI study to differentiate the cortical representations of different perceptual modes of listening, 25 namely synthetic and analytic. Additionally, this stimulus will also be used in an EEG study to explore 26 the neural correlates of the Pitch Onset Response (POR). Overall, this project will relate perceptual 27 characterizations of the illusory stimulus to neurophysiological findings to provide new insights to the 28 field of pitch perception, which in turn could motivate the development of novel pitch processing 29 strategies in auditory prostheses. The research performed and training provided during this award will 30 enable the candidate to achieve her goal of developing an independent research program that 31 employs both neurophysiological and behavioral approaches to investigate auditory phenomena.

1 项目概要/摘要 2 音高和和声在语音和音乐的感知中起着决定性作用，并且对于 3 听觉场景中声音的感知组织。有听力损失的听众，以及 4 尤其是那些植入人工耳蜗的人，其音调感知能力存在显着缺陷，因为 5 当前的声音处理策略无法提供稳健的音调提示。尽管我们的技术取得了进步 6 了解音调在我们的听觉系统中如何被感知、编码和表示，有 7 我们对音高（尤其是和声）的基本理解仍存在重大差距 8 代表听觉皮层。更好地理解涉及的神经转换 9 音高感知应该有助于设计更有效的神经和声学假体。整体 10 该项目的目标是理解音高和和声的神经表征以及 11 使用行为组合阐明时间整合在音调感知中的作用 12（心理声学）、电生理学（EEG）和神经影像技术（fMRI）。在指导下 13 在该项目的 K99 阶段，候选人将对这两个总体主题进行研究。 14 fMRI 将用于研究和声复合音调的哪些特性在听觉皮层的 15 个前侧区域（目标 1）。使用仔细控制的刺激，这项研究应该 16 为谐波是否比非谐波引起更强的反应提供了强有力的证据 17 位于听觉皮层。候选人还将使用小说进行一系列行为实验 18 产生虚幻虚拟音高感知的刺激，为量化音高提供经验数据 19 个参数控制音调感知中的时间整合（目标 2）。这些行为 20 项实验将增加对音调感知的时间方面的重要理解，而这些方面并不当前的音高感知模型中考虑了 21。在项目的R00阶段，候选人 22 将利用目标 1 和 2 的技术和发现来研究音调的两个重要方面 23 处理和感知。目标 2 中研究的刺激的新颖修改将用于 24 一项功能磁共振成像研究，旨在区分不同感知聆听模式的皮质表征， 25 即综合型和分析型。此外，这种刺激也将用于脑电图研究，以探索 26 音调起始响应 (POR) 的神经相关性。总的来说，这个项目将涉及感知 27 神经生理学发现的虚幻刺激的特征为神经生理学发现提供了新的见解 28个音高感知领域，这反过来又可以促进新型音高处理的发展听觉假体的 29 种策略。在此奖项期间进行的研究和提供的培训将 30 使候选人能够实现开发独立研究计划的目标 31 采用神经生理学和行为学方法来研究听觉现象。