Multilevel Comprehensive HIV Prevention for South African Adolescent Girls and Young Women

南非少女和年轻妇女的多层次综合艾滋病毒预防

基本信息

批准号：
10620397
负责人：
GERI R DONENBERG
金额：
$ 8.46万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10620397
关键词：
19 year old AIDS prevention Address Age Attitude Behavior Caregivers Communication Data Daughter Development Plans Doctor of Philosophy Ensure Family Female Female Adolescents Foundations Goals HIV HIV/STD Incidence Intervention Knowledge Mentors Mentorship Outcome Parents Physicians Prevention Prevention program Randomized Controlled Trials Reading Research Research Activity Role Scientist Sexually Transmitted Diseases South African Specific qualifier value Testing Training Training Activity Underrepresented Minority Women&apos s Health adolescent health arm base career career development experience follow-up global health health disparity high risk implementation science improved medical schools meetings parent grant parent project primary outcome research study secondary outcome skills stem transmission process young woman

项目摘要

South African Adolescent Girls and Young Women (AGYW), ages 15 – 19 years-old, are at high risk of new sexually transmitted infections, including HIV. Ongoing efforts to stem transmissions have been disappointing. Family-based prevention programs are an underutilized approach in the HIV prevention toolkit, despite evidence of their promise in improving AGYW health prevention attitudes and behaviors. This one-year diversity supplement will support Alyssa Debra's career development as a physician scientist who is beginning her PhD after completing two years of medical school. Her research study builds on the parent grant, a 2-arm randomized controlled trial testing a female caregiver (FC)-daughter HIV/STI prevention program on South African AGYW STI and HIV incidence. Using UG3 pilot data from the parent study, Alyssa will evaluate two theoretical mechanisms believed to explain change in AGYW STI and HIV outcomes: FC-AGYW relationships and communication, and AGYW HIV/STI knowledge, attitudes, and skills. Alyssa will examine change in these mechanisms from baseline to 6-month follow-up (after the intervention), and she will compare changes in the experimental and control arms. Findings will set the stage to evaluate the role of these mechanisms on the primary and secondary outcomes of the parent project. The career development plan specifies a combination of hands-on experiential training, coursework, guided readings, one-on-one meetings with mentors, and networking opportunities to achieve Alyssa's three training goals: (1) global health research, (2) implementation science, and (3) adolescent health disparities. Alyssa has assembled an expert mentorship team who will facilitate her engagement in research and training activities. Each month, she will review her progress with Dr. Donenberg to ensure she is on track to meet her deliverables. Taken together, the combination of experiences, close mentorship, and oversight by Dr. Donenberg, Alyssa will receive a strong foundation to prepare her for a future research career.

15 至 19 岁的南非少女和年轻女性 (AGYW) 面临着较高的患病风险新的性传播感染，包括艾滋病毒，我们一直在努力阻止传播。令人失望的是，以家庭为基础的预防计划在艾滋病毒预防方面并未得到充分利用。尽管有证据表明它们有望改善 AGYW 健康预防态度和行为。这项为期一年的多元化补充课程将支持 Alyssa Debra 作为医师科学家的职业发展她在医学院毕业两年后即将开始攻读博士学位。家长补助金，一项 2 臂随机对照试验，测试女性看护者 (FC) 女儿 HIV/STI 南非 AGYW STI 和 HIV 发病率预防计划使用来自家长的 UG3 试点数据。在这项研究中，Alyssa 将评估两种被认为可以解释 AGYW STI 和 HIV 变化的理论机制结果：FC-AGYW 关系和沟通，以及 AGYW HIV/STI 知识、态度和 Alyssa 将检查这些机制从基线到 6 个月随访（术后）的变化。干预），她将比较实验组和对照组的变化，为研究结果奠定基础。评估这些机制对父项目的主要和次要成果的作用。职业发展计划指定了实践体验培训、课程作业、指导性培训的结合。阅读、与导师一对一的会面以及社交机会来实现 Alyssa 的三个目标培训目标：(1) 全球健康研究，(2) 实施科学，(3) 青少年健康差异。艾莉莎组建了一个专家指导团队，帮助她参与研究和每个月，她都会与 Donenberg 博士一起回顾自己的进展，以确保她能够顺利完成培训活动。综合考虑她的经验、密切指导和监督。 Donenberg 博士为 Alyssa 奠定了坚实的基础，为她未来的研究生涯做好准备。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Harmonizing Implementation and Outcome Data Across HIV Prevention and Care Studies in Resource-Constrained Settings.

协调资源有限环境中艾滋病毒预防和护理研究的实施和结果数据。

DOI：
10.1007/978-3-030-82193-7_42
发表时间：
2022
期刊：
Global implementation research and applications
影响因子：
0
作者：
Donenberg GR
通讯作者：
Donenberg GR

An individually randomized controlled trial of a mother-daughter HIV/STI prevention program for adolescent girls and young women in South Africa: IMARA-SA study protocol.

DOI：
10.1186/s12889-021-11727-3
发表时间：
2021-09-20
期刊：
BMC public health
影响因子：
4.5
作者：
Donenberg GR;Atujuna M;Merrill KG;Emerson E;Ndwayana S;Blachman-Demner D;Bekker LG
通讯作者：
Bekker LG

Mental health outcomes of a pilot 2-arm randomized controlled trial of a HIV-prevention program for South African adolescent girls and young women and their female caregivers.