Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study

弗雷明汉研究中用于阿尔茨海默病风险检测的精确大脑健康监测

• 批准号: 10625625
• 负责人: Rhoda Au
• 金额: $ 34.65万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625625
• 关键词: Age; Alzheimer' s Disease; Alzheimer' s disease risk; Amyloid; Amyloid beta-Protein; Area; Biological Markers; Cellular Phone; Cognitive; Cohort Studies; Communities; Data; Data Collection; Detection; Diagnosis; Elderly; Ethnic group; Framingham Heart Study; Healthcare; Heterogeneity; Hispanic; Hispanic Populations; Income; Insurance; Latino; Latinx; Measures; Monitor; Not Hispanic or Latino; Participant; Persons; Population; Race; Scanning; Site; brain health; cognitive testing; cohort; digital; ethnic diversity; lens; population based; racial and ethnic; smartphone Application; β-amyloid burden

Project Summary This supplement seeks to extend the data collection of lens amyloid and smartphone cognitive data to include participants who are Hispanic-Latino/LatinX descent. These data will offset the limited racial/ethnic heterogeneity of the FHS cohort, which is largely non-Hispanic White. The Rio Grande site from which participants will be invited to participate is 99% Hispanic-Latino/LatinX. An estimated 25% of the elderly population in this area are diagnosed with AD dementia and there is concern that this is an underestimate because of income and limited healthcare insurance. The first aim will conduct an ocular scan that provides an Aß biomarker of AD measured in the lens to characterize Aβ burden in a community-based population of Hispanic-Latino/LatinX descent whose age ranges overlap with that of the FHS cohort. The second aim includes using smartphone applications to collect 1 year of longitudinal cognitive metrics from participants who are of Hispanic-Latino/LatinX descent that can be combined with 1 year of longitudinal cognitive metrics from the FHS cohort so that characterization results are more generalizable. Currently the Framingham Heart Study cohort from which the lens amyloid and digital cognitive assessment are to be collected is estimated to be 3,375 of which 131 are projected to be of Hispanic/Latino/LatinX descent. This is well under the 18.7% of the U.S. population that is comprised of people from this ethnic/racial group. To collect data is that is appropriately representative (e.g., 18.7%) will require collecting data from an additional 500 participants from the Rio Grande site.

项目摘要 该补充旨在扩展透镜淀粉样蛋白和智能手机认知数据的数据收集到包括 西班牙裔拉丁美洲/拉丁裔下降的参与者。这些数据将抵消有限的种族/种族 FHS队列的异质性，主要是非西班牙裔白色。里奥格兰德网站 参与者将被邀请参加99％的西班牙裔拉蒂诺/拉丁裔。估计较长的25％ 该领域的人口被诊断出患有AD痴呆症，并担心这是一个低估的 由于收入和有限的医疗保险。第一个目标将进行眼扫描 在镜头中测量的AD的Aß生物标志物，以表征基于社区的人群AβBurnen 西班牙裔拉丁美洲/拉丁裔血统的年龄与FHS队列的重叠范围。第二个 目的包括使用智能手机应用程序收集1年的纵向认知指标 西班牙裔拉丁美洲/拉丁裔血统的参与者可以与1年的纵向结合 来自FHS队列的认知指标，因此表征结果更具概括性。现在 弗雷明汉心脏研究队列的晶状体淀粉样蛋白和数字认知评估应为 估计收集的是3,375，其中131个预计为西班牙裔/拉丁裔/拉丁裔下降。这是 远低于由这个族裔/种族群体的人们组成的美国人口的18.7％。收集 数据是适当的代表性（例如，18.7％）将需要从500的其他500中收集数据 里奥格兰德网站的参与者。