INVESTIGATING HOW NOVELTY ENHANCES FEAR LEARNING & MEMORY

调查新奇事物如何增强恐惧学习

基本信息

批准号：
10580151
负责人：
Victor A Cazares
金额：
$ 43.51万
依托单位：
WILLIAMS COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10580151
关键词：
Ablation Affect Amygdaloid structure Animals Anxiety Attenuated Behavior Brain Conditioned Stimulus Cues Data Disease Dorsal Environment Exposure to Extinction Fluorescence Fright Future Genetic Genotype Goals Hippocampus Human Hybrids Immunofluorescence Immunologic Individual Investigation Knowledge Label Learning Maps Measures Medial Mediating Memory Modernization Mouse Strains Mus Neurons Neurosciences Outcome Patients Pattern Phenotype Prefrontal Cortex Relapse Reporter Research Rodent Model Role Shapes Students Testing Therapeutic Time Training Transgenic Organisms Trauma anxiety-related disorders college conditioned fear design empowerment experience experimental study individual variation insight interest learning extinction memory recall neural neural circuit neuromechanism novel novel strategies recruit response tool

Ablation Affect Amygdaloid structure Animals Anxiety Attenuated Behavior Brain Conditioned Stimulus Cues Data Disease Dorsal Environment Exposure to Extinction Fluorescence Fright Future Genetic Genotype Goals Hippocampus Human Hybrids Immunofluorescence Immunologic Individual Investigation Knowledge Label Learning Maps Measures Medial Mediating Memory Modernization Mouse Strains Mus Neurons Neurosciences Outcome Patients Pattern Phenotype Prefrontal Cortex Relapse Reporter Research Rodent Model Role Shapes Students Testing Therapeutic Time Training Transgenic Organisms Trauma anxiety-related disorders college conditioned fear design empowerment experience experimental study individual variation insight interest learning extinction memory recall neural neural circuit neuromechanism novel novel strategies recruit response tool

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项目摘要

Project Summary We will study a highly characterized forms of learning, fear extinction (FE), which is known to underlie several maladaptive phenotypes in trauma- and anxiety-related disorders. Exposure therapy is largely based on fear FE, during which individuals are repeatedly exposed to a fear-conditioned stimulus in the absence of the aversive outcome, leading to a gradual decrease in the fear response. FE training is believed to create a new memory that inhibits learned fear responses. Previous research suggests that the activation of neurons encoding FE memories rapidly wanes over time, resulting in poor FE recall and the return of fear. We and others have found that exposure to novelty enhances FE learning. In this proposal we seek: (1) to determine the specific parameters under which novelty enhances FE learning; (2) to interrogate the role of the hippocampus modulating the FE-enhancing effects of novelty; and (3) to map how neural activation patterns are altered in the presence or absence of novelty during FE. Finally, given the high individual variation in the responsiveness to exposure therapy among humans, we will investigate the role of genetic background in shaping functional relationships between the efficacy of FE and neural activation.

项目摘要我们将研究一种高度特征的学习形式，恐惧灭绝（FE），这是众所周知的创伤和焦虑有关的疾病中的适应不良表型。暴露疗法主要基于恐惧在此期间，个人反复接触到恐惧条件的刺激厌恶结果，导致恐惧反应逐渐减少。 FE培训被认为创造了新的抑制学习恐惧反应的记忆。先前的研究表明神经元的激活随着时间的流逝，编码FE记忆的编码迅速减弱，导致FE召回不良和恐惧返回。我们和其他人发现接触新颖性可以增强FE学习。在此提案中，我们寻求：（1）确定新颖性增强Fe学习的特定参数；（2）审问海马调节新颖性的增强作用；（3）绘制神经激活方式在Fe期间存在或不存在新颖性的情况下会改变。最后，鉴于个人的个人变化很高对人类暴露疗法的反应，我们将研究遗传背景在 FE和神经激活的功效之间的功能关系。