Cannula Tip with Integrated Volume and Pressor Sensors for Rotary Blood Pump Control

带有集成容量和压力传感器的插管尖端，用于旋转血泵控制

基本信息

批准号：
10613480
负责人：
Joshua P Cysyk
金额：
$ 75.74万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10613480
关键词：
Acute Algorithms Animals Apical Arrhythmia Artificial Organs Blood Blood flow Cannulas Cardiac Catheters Cause of Death Cessation of life Chronic Congestive Heart Failure Coupled Data Destinations Detection Development Device Designs Devices Drops Echocardiography Electrodes Electronics Event Exercise Feedback Generations Goals Heart Heart Diseases Heart failure Hospitals Implant Left Left ventricular structure Manuals Measurement Measures Mechanics Modeling Monitor Myocardial Myocardium Oxygen Consumption Patients Performance Physiologic intraventricular pressure Physiological Physiology Platinum Pump Quality of life Recovery Research Respiratory Diaphragm Self-Help Devices Series Sheep Speed Stress Stroke Suction System Systems Development Testing Therapeutic Time Transplantation United States Ventricular Work adverse event risk base biomaterial compatibility blood pump design exercise capacity experience flexibility implantation implanted sensor improved in vivo in vivo evaluation left ventricular assist device novel pressure pressure sensor prevent prototype response risk minimization seal sensor standard of care ventricular assist device

项目摘要

Project Summary / Abstract The use of left ventricular assist devices (LVADs) has been a viable therapeutic option for end-stage heart failure patients. These devices are commonly used as bridge-to-transplant or destination therapy, and as the risk of adverse events has been reduced with improved device design, LVAD support is being considered as an option for class III heart failure patients as well. Recently, the use of continuous flow LVADs has become common due to their small size and improved reliability. However, control of these devices can be challenging as opposed to the previous generation of pulsatile devices. Current control systems operate the pump at a fixed speed set by the clinician. The speed is set high enough to provide adequate circulatory support but not too high as to cause suction and ventricular collapse. These control systems cannot increase flow in response to physiologic demand and therefore, patients with these devices have limited exercise capacity. As patients are now leaving the hospital and returning to their daily activities, a control system that responds to patient demand is necessary. The major impediment to control system development is the availability of implantable sensors capable of assessing ventricular unloading. The primary objective of the proposed research is to develop a “smart” cannula tip with integrated sensors for measuring the pressure and volume of the left ventricle. A control algorithm will be developed to adjust pump speed based on the sensor data obtained from the cannula tip. The control algorithm will adapt pump flow to changes in circulatory demand in order to maintain ventricular unloading, provide adequate blood flow, and prevent adverse suction events. The experience and expertise of the Penn State Division of Artificial Organs in the development of LVADs and implantable electronics will be utilized to develop and fabricate the proposed device. A prototype cannula tip and control system have been tested in acute ovine studies with the HeartMate II LVAD. We propose to evaluate the biocompatibility of the device, stability of the volume and pressure sensors, and functionality of the automatic control system in a series of acute and chronic ovine studies.

项目摘要 /摘要左心室辅助设备（LVADS）的使用一直是终阶段的可行治疗选择心力衰竭患者通常用作桥梁到移植或目的地治疗随着设备设计的改进，由于不良事件的风险降低了，LVAD支持正在得到被认为是III类心力衰竭患者的一种选择。由于其尺寸较小和可靠性，LVAD已变得很普遍。与上一代脉动设备相反，设备可能具有挑战性系统以临床医生设定的固定速度操作泵。足够的循环支撑，但不会太高，以使Suse Suse Suse Suntricular崩溃系统不能响应生理需求而增加流量，因此，这些患者设备的运动能力有限。日常活动，一种对患者需求的反应的控制系统。控制系统开发是能够评估心室的植入传感器的可用性卸载。集成传感器，用于测量左心室的压力和体积。根据从套管尖端获得的传感器数据来调整泵速度算法将使泵流动到圆形需求的变化以便为主体卸载，提供足够的血液流量，并防止不利的事件宾夕法尼亚州人造器官的专业知识在LVAD和可植入的开发方面电子设备将被用于开发和限制支撑设备。对照系统已在我们建议的急性卵子研究中进行了测试评估设备的生物相容性，体积和压力传感器的稳定性以及功能一系列急性和慢性卵巢研究中的自动控制系统。