The Macrophage: Intersection of Pathogenic and Protective Inflammation

巨噬细胞：致病性炎症和保护性炎症的交叉点

• 批准号: 7803870
• 负责人: ANDREW D ROBERTSON
• 金额: $ 0.7万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-15 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7803870
• 关键词: Address; Alberta province; Animals; Area; Arts; Atherosclerosis; Biological Models; Biology; Canada; Cells; Development; Disease; Forms Controls; Homeostasis; Immunity; Infection; Inflammation; Inflammatory; Investigation; Knowledge; Link; Macrophage Activation; Malignant Neoplasms; Metabolic Diseases; Molecular; Outcome; Pathogenesis; Physiological Processes; Play; Process; Regulation; Research Personnel; Role; Scanning; Sterility; Text; Work; Wound Healing; abstracting; insight; macrophage; meetings; neglect; pathogen; sensor; symposium; trafficking

DESCRIPTION (provided by applicant): ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== This proposal is to request support for a Keystone Symposia meeting entitled The Macrophage: Intersection of Pathogenic and Protective Inflammation, organized by Peter J. Murray, Sabine Ehrt and Ajay Chawla, which will be held in Alberta, Canada from February 12 - 17, 2010. Recent insights into macrophage biology have focused on their prodigiously varied roles: as sensors, effectors and regulators of immunity; as cells central to tissue repair and homeostasis; as the host cell of diverse pathogens; and as cells pivotal to the pathogenesis of numerous inflammatory diseases. The conservation of underlying common mechanisms of macrophage activation and subsequent control forms the overall thematic organization of this meeting. A special focus will be on areas of macrophage biology that are often neglected, including the role of macrophages in inflammatory diseases not obviously linked to pathogens including atherosclerosis, cancer, metabolic diseases and other forms of 'sterile' inflammation. The meeting is intended to provide a state-of-the-art overview of macrophage biology, to highlight the translational implications of this work, to provide researchers with access to diverse model systems, topics and levels of investigation, and to help define the most important questions to be addressed. Furthermore, the pairing of this and the Advances in Molecular Mechanisms of Atherosclerosis meeting - which will share four sessions and a keynote with this meeting - is unique and enhances opportunities for exchanges between researchers who do not typically interact. Macrophages have vital roles in virtually every disease process. Understanding the development, trafficking and regulation of macrophages is therefore an important component of understanding disease and normal physiological process. The Keystone Symposia meeting on The Macrophage: Intersection of Pathogenic and Protective Inflammation will address several gaps in knowledge in the field of macrophage biology through a focus on whole animal studies of infection where macrophages play essential roles in the outcome of protective or pathogenic immunity.

描述（由申请人提供）： ================= 注意：此摘要是从申请中提取的，未经 SRA 验证。当申请扫描过程出现问题时，提取的文本可能不正确或不完整。 ================= 本提案旨在请求支持由 Peter J. Murray、Sabine Ehrt 和 Ajay Chawla 组织、将于 2010 年 2 月 12 日至 17 日在加拿大艾伯塔省举行的题为“巨噬细胞：致病性和保护性炎症的交叉点”的 Keystone 研讨会。最近对巨噬细胞生物学的见解集中在它们的巨大不同作用上：作为免疫的传感器、效应器和调节器；作为组织修复和体内平衡的核心细胞；作为多种病原体的宿主细胞；作为许多炎症性疾病发病机制的关键细胞。巨噬细胞激活和随后控制的潜在共同机制的保护构成了本次会议的总体主题组织。特别关注的是经常被忽视的巨噬细胞生物学领域，包括巨噬细胞在与病原体没有明显联系的炎症性疾病中的作用，包括动脉粥样硬化、癌症、代谢性疾病和其他形式的“无菌”炎症。这次会议旨在提供巨噬细胞生物学的最新概述，强调这项工作的转化意义，为研究人员提供不同的模型系统、主题和研究水平的机会，并帮助定义最需要解决的重要问题。此外，本次会议与动脉粥样硬化分子机制进展会议（该会议将与本次会议共享四个会议和一个主题演讲）的配对是独一无二的，并且增加了通常不互动的研究人员之间的交流机会。巨噬细胞在几乎所有疾病过程中都发挥着至关重要的作用。因此，了解巨噬细胞的发育、运输和调节是了解疾病和正常生理过程的重要组成部分。关于巨噬细胞：致病性和保护性炎症的交叉点的 Keystone 研讨会将通过重点关注感染的整体动物研究，解决巨噬细胞生物学领域的一些知识空白，其中巨噬细胞在保护性或致病性免疫的结果中发挥着重要作用。