Neurobehavioral Effects of Frequent Co-use of Alcohol and Cannabis

经常同时使用酒精和大麻对神经行为的影响

• 批准号: 10608419
• 负责人: EMILY B ANSELL
• 金额: $ 73.01万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608419
• 关键词: Address; Alcohol consumption; Alcohols; Behavior; Behavioral; Behavioral Mechanisms; Biological; Blood; Brain; Cannabis; Consumption; Control Groups; Corpus striatum structure; Cues; Data; Drug usage; Ecological momentary assessment; Exhibits; Female; Functional Magnetic Resonance Imaging; Future; Heavy Drinking; Hydrocortisone; Individual; Individual Differences; Intervention; Knowledge; Life; Marijuana; Measurement; Measures; Neurosecretory Systems; Outcome; Participant; Pathway interactions; Pattern; Persons; Plasma; Prevention; Process; Reporting; Risk; Risk Factors; Role; Sampling; Sex Differences; Stress; Substance Use Disorder; Time; Work; alcohol craving; alcohol response; binge drinker; blood oxygen level dependent; cannabis craving; comparison control; craving; cue reactivity; experience; follow-up; male; marijuana legalization; marijuana use; marijuana user; neural; neurobehavioral; neuroimaging; prevent; prospective; recruit; response; secondary analysis; sex; substance use; substance user; time interval

Project Summary Simultaneous use of alcohol and marijuana/cannabis (SAM) leads to increased craving, use, and consequences compared to single use of either alcohol or cannabis. However, there is a dearth of knowledge regarding the neural, neuroendocrine, and behavioral differences in SAM users that increases risk for these negative outcomes. The current proposal aims to address this significant gap in knowledge by examining how stress related neural and neuroendocrine processes may differ in SAM users relative to single substance users or a control group. A sex-balanced sample of four hundred forty male and female individuals reporting SAM use, alcohol use only, cannabis use only, or neither binge/heavy alcohol use nor cannabis use will be recruited to complete a neuroimaging session and three 14-day bursts of ecological momentary assessment (EMA) over the course of one year. During the neuroimaging session, participants will complete a stress cue reactivity task while undergoing fMRI and will also have blood drawn to assess stress-induced cortisol response. Participants will complete a baseline EMA burst that focuses on daily experiences of stress, craving and drug use, and will complete follow-up bursts at 6- and 12-months post-baseline. This proposal aims to better understand how stress processes are related to increased risk among SAM users. Specifically this proposal will investigate 1) how neural and neuroendocrine responses to stress are moderated by group (i.e., SAM, alcohol-only, cannabis-only, control), sex, and the interaction of group x sex; 2) how group, sex, and group x sex interactions, and neural/ neuroendocrine responses moderate the momentary relationships between stress and craving/use in daily life; and 3) how group, sex, and group x sex interactions, and neural/neuroendocrine responses moderate the trajectory of craving/use over a one-year follow-up period. Broadly, we expect that while single substance users will have some dysregulation, SAM users will exhibit the greatest stress dysregulation relative to controls, and females (vs. males) will demonstrate greater dysregulation of neural/neuroendocrine responses to stress, greater momentary relationships between stress and craving/use, and steeper trajectories of craving/use. Successful completion of these aims will significantly advance our understanding of the mechanisms by which SAM use increase risk for substance use disorders and other negative outcomes, which will be key in guiding future intervention and prevention efforts.

项目摘要 同时使用酒精和大麻/大麻（SAM）导致渴望，使用和 与单次使用酒精或大麻相比，后果。但是，缺乏知识 关于SAM用户的神经，神经内分泌和行为差异，以增加这些风险 负结果。当前的建议旨在通过研究如何解决这一重要差距 SAM用户相对于单一物质用户，与压力相关的神经和神经内分泌过程可能有所不同 或对照组。性别平衡的样本，由四十四十男性和女性报告SAM 使用，仅使用酒精，仅使用大麻，或者既不会招募暴饮暴食，也不会使用大麻使用大麻 完成神经影像学和三次生态瞬时评估（EMA）的爆发 一年的课程。在神经影像学课程中，参与者将完成压力提示反应性任务 在接受功能磁共振成像的同时，还将吸收血液来评估压力诱导的皮质醇反应。参与者 将完成一个基线EMA爆发，重点是日常压力，渴望和吸毒的经历，并将 在基线后6个月和12个月内完成后续爆发。该建议旨在更好地了解 压力过程与SAM用户的风险增加有关。具体而言，该建议将调查1） 神经和神经内分泌对压力的反应如何受到组的调节（即SAM，仅酒精， 仅大麻，控制），性别和X组性别的相互作用； 2）群体，性别和X组的性别如何 相互作用，神经/神经内分泌反应缓解了压力与 渴望/在日常生活中使用； 3）群体，性别和X组性互动以及神经/神经内分泌 响应在一年的随访期内节省了渴望/使用的轨迹。从广义上讲，我们希望 虽然单一药物用户会出现一些失调，但SAM用户将表现出最大的压力 相对于对照组的失调和女性（与男性）的失调将显示出更大的失调 神经/神经内分泌对压力的反应，压力与渴望/使用之间的更大的瞬时关系， 和渴望/使用的陡峭轨迹。这些目标的成功完成将大大推动我们的 了解SAM使用的机制会增加对物质使用障碍的风险和其他 负面结果，这将是指导未来的干预和预防工作的关键。