2023 Physical Science of Cancer GRC/GRS

2023年癌症物理科学GRC/GRS

基本信息

批准号：
10609179
负责人：
Jennifer M Munson
金额：
$ 1.7万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-20 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10609179
关键词：
Address Big Data Biological Biology Biomedical Engineering Biophysics Cancer Biology Cancer Science Cancerous Cells Chemistry Collaborations Communication Complex Computational Science Data Data Science Dedications Development Diagnostic Discipline Disease Engineering Environment Exposure to Fostering Foundations Funding Agency Future Genetic Goals Hearing Hour Human body Individual Interdisciplinary Study International Journals Malignant Neoplasms Mathematics Medicine Mentorship Methodist Church Methodology Methods Minnesota Molecular Oncology Oral Organ Participant Patients Physics Postdoctoral Fellow Productivity Recurrent disease Research Research Personnel Role Scientist Shapes Signal Transduction Site System Systemic disease Technology Texas Time Tissues Training Translating Virginia Voice Wisconsin anticancer research cancer type career clinical translation design expectation graduate student individual patient innovation interdisciplinary approach mathematical model mechanical properties meetings multidisciplinary next generation novel personalized diagnostics personalized medicine physical property physical science posters programs role model social success symposium synergism tool translational approach translational potential tumor tumor initiation tumor microenvironment tumor progression unpublished works

项目摘要

Project Summary/Abstract Despite the wide variety of genetic and molecular information available to characterize a patient's tumor, a precise individual prediction of cancer progression is only possible to a limited extend. This suggests that vital data about tumor progression are missing such as the physical and mechanical properties of cells and surrounding tissue. Considering the complexity of cancer as a systemic disease recently high expectations have been raised that an interdisciplinary approach by combining biology, chemistry, mathematics, engineering, big data, and physics with biomedicine will lead to convergent oncology. Emergent phenomena which are not directly triggered by a specific molecule can be only understood by a convergent approach. Partial support is requested for the 3rd iteration of the "Physical Science of Cancer" Gordon Research Conference (GRC) to be held from Feb.5-10, 2023, and the 2nd iteration of the “Physical Science of Cancer” Gordon Research Seminar (GRS) to be held from Feb.4-5, 2023. These meetings will be held at the GRC-selected conference hotel (The Grand Galvez) in Galveston, Texas. The conference is promised to provide a forum for the presentation and discussion of recent advances and new ideas on multidisciplinary approaches and their success in understanding fundamental cancer progression as well as in developing potential translational perspectives. The long-term goal of this GRC is to facilitate the development and use of approaches to extend the range of cancer targets that can be tackled successfully. These will be achieved with the following aims: (1) Review advances and identify challenges in quantitative approaches in cancer. (2) Train the next generation of scientists to quantitatively investigate the underlying physical mechanisms that drive cancer (GRS) and facilitate diversity participation. (3) Foster new collaborations with emphasis on using quantitative approaches to address challenges in cancer. Session topics have been selected on the basis of their potential impact on key scientific challenges of the field and for their strength in transdisciplinary approaches. A focus on giving diverse voices, in background, stage of career, and discipline will be central to our program. We will introduce inclusive mentorship as a primary focus in order to better train and foster the next generation of multi-disciplinary cancer researchers. Poster sessions will provide ample opportunities for engagement between investigators at all levels. We anticipate that scientific interactions during this conference will impact cancer research in significant ways and result in establishing productive multi-disciplinary research collaborations. Collectively this conference will highlight the significant progress in the last four years, and catalyze the development of new concepts and synergies that will aim to shape the future of Physical Sciences in Cancer and allow us to holistically study phenomena. Ultimately, the dynamic interactions among these systems shape the forces that drive tumor initiation, progression, metastatic spread, and disease recurrence. The application of physics and mathematics foundations to the molecular, cellular, tissue, and organ level basis of cancer has revealed fundamental changes during disease that are reflected across cancer types and stages. In this conference we will hear from experts applying physical sciences to cancer to study disease phenomena across scales and systems.

项目概要/摘要尽管有各种各样的遗传和分子信息可用于表征患者的肿瘤，对癌症进展的精确个体预测只能在有限的范围内进行，这表明这一点至关重要。缺少有关肿瘤进展的数据，例如细胞的物理和机械特性以及考虑到癌症作为一种全身性疾病的复杂性，最近人们的期望很高。人们提出了一种跨学科的方法，将生物学、化学、数学、工程学、大数据、物理学与生物医学将导致肿瘤学的趋同现象。由特定分子直接触发只能通过收敛方法来理解。要求第三次“癌症物理科学”戈登研究会议 (GRC) 2023年2月5日-10日举办，第二届“癌症物理科学”戈登研究研讨会 (GRS)将于2023年2月4日至5日举行。这些会议将在GRC选定的会议酒店（The Grand Galvez）在德克萨斯州加尔维斯顿举行，会议承诺提供一个演示和论坛。讨论多学科方法的最新进展和新想法及其成功了解癌症的基本进展以及发展潜在的转化观点。该 GRC 的长期目标是促进方法的开发和使用，以扩大可以成功解决的癌症目标这些目标将通过以下目标实现： (1) 回顾癌症定量方法的进展并确定挑战。（2）培养下一代科学家定量研究潜在的物理机制驱动癌症 (GRS) 并促进多元化参与。 (3) 促进新的合作，重点是使用定量方法来应对挑战癌症。会议主题是根据其对该领域关键科学挑战的潜在影响来选择的以及他们在跨学科方法方面的实力，注重在背景和舞台上发出不同的声音。职业生涯和纪律将是我们计划的核心，我们将引入包容性指导作为主要内容。重点，以更好地培训和培养下一代多学科癌症研究人员。我们预计会议将为各级研究人员之间的交流提供充足的机会。本次会议期间的科学互动将对癌症研究产生重大影响，并导致建立富有成效的多学科研究合作。总的来说，这次会议将强调过去四年中取得的重大进展，并促进开发新概念和协同作用，旨在塑造癌症物理科学的未来并让我们能够全面地研究现象，最终形成这些系统之间的动态相互作用。驱动肿瘤发生、进展、转移扩散和疾病复发的力量。癌症的分子、细胞、组织和器官水平基础的物理和数学基础揭示了疾病期间的根本变化，这些变化反映在癌症类型和阶段中。会议上我们将听到专家将物理科学应用于癌症来研究跨领域的疾病现象规模和系统。