2023 Physical Science of Cancer GRC/GRS

2023年癌症物理科学GRC/GRS

• 批准号: 10609179
• 负责人: Jennifer M Munson
• 金额: $ 1.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-20 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609179
• 关键词: Address; Big Data; Biological; Biology; Biomedical Engineering; Biophysics; Cancer Biology; Cancer Science; Cancerous; Cells; Chemistry; Collaborations; Communication; Complex; Computational Science; Data; Data Science; Dedications; Development; Diagnostic; Discipline; Disease; Engineering; Environment; Exposure to; Fostering; Foundations; Funding Agency; Future; Genetic; Goals; Hearing; Hour; Human body; Individual; Interdisciplinary Study; International; Journals; Malignant Neoplasms; Mathematics; Medicine; Mentorship; Methodist Church; Methodology; Methods; Minnesota; Molecular; Oncology; Oral; Organ; Participant; Patients; Physics; Postdoctoral Fellow; Productivity; Recurrent disease; Research; Research Personnel; Role; Scientist; Shapes; Signal Transduction; Site; System; Systemic disease; Technology; Texas; Time; Tissues; Training; Translating; Virginia; Voice; Wisconsin; anticancer research; cancer type; career; clinical translation; design; expectation; graduate student; individual patient; innovation; interdisciplinary approach; mathematical model; mechanical properties; meetings; multidisciplinary; next generation; novel; personalized diagnostics; personalized medicine; physical property; physical science; posters; programs; role model; social; success; symposium; synergism; tool; translational approach; translational potential; tumor; tumor initiation; tumor microenvironment; tumor progression; unpublished works

Project Summary/Abstract Despite the wide variety of genetic and molecular information available to characterize a patient's tumor, a precise individual prediction of cancer progression is only possible to a limited extend. This suggests that vital data about tumor progression are missing such as the physical and mechanical properties of cells and surrounding tissue. Considering the complexity of cancer as a systemic disease recently high expectations have been raised that an interdisciplinary approach by combining biology, chemistry, mathematics, engineering, big data, and physics with biomedicine will lead to convergent oncology. Emergent phenomena which are not directly triggered by a specific molecule can be only understood by a convergent approach. Partial support is requested for the 3rd iteration of the "Physical Science of Cancer" Gordon Research Conference (GRC) to be held from Feb.5-10, 2023, and the 2nd iteration of the “Physical Science of Cancer” Gordon Research Seminar (GRS) to be held from Feb.4-5, 2023. These meetings will be held at the GRC-selected conference hotel (The Grand Galvez) in Galveston, Texas. The conference is promised to provide a forum for the presentation and discussion of recent advances and new ideas on multidisciplinary approaches and their success in understanding fundamental cancer progression as well as in developing potential translational perspectives. The long-term goal of this GRC is to facilitate the development and use of approaches to extend the range of cancer targets that can be tackled successfully. These will be achieved with the following aims: (1) Review advances and identify challenges in quantitative approaches in cancer. (2) Train the next generation of scientists to quantitatively investigate the underlying physical mechanisms that drive cancer (GRS) and facilitate diversity participation. (3) Foster new collaborations with emphasis on using quantitative approaches to address challenges in cancer. Session topics have been selected on the basis of their potential impact on key scientific challenges of the field and for their strength in transdisciplinary approaches. A focus on giving diverse voices, in background, stage of career, and discipline will be central to our program. We will introduce inclusive mentorship as a primary focus in order to better train and foster the next generation of multi-disciplinary cancer researchers. Poster sessions will provide ample opportunities for engagement between investigators at all levels. We anticipate that scientific interactions during this conference will impact cancer research in significant ways and result in establishing productive multi-disciplinary research collaborations. Collectively this conference will highlight the significant progress in the last four years, and catalyze the development of new concepts and synergies that will aim to shape the future of Physical Sciences in Cancer and allow us to holistically study phenomena. Ultimately, the dynamic interactions among these systems shape the forces that drive tumor initiation, progression, metastatic spread, and disease recurrence. The application of physics and mathematics foundations to the molecular, cellular, tissue, and organ level basis of cancer has revealed fundamental changes during disease that are reflected across cancer types and stages. In this conference we will hear from experts applying physical sciences to cancer to study disease phenomena across scales and systems.

项目摘要/摘要 尽管可用于表征患者肿瘤的遗传和分子信息多种多样，但 精确的个人预测癌症进展只能有限地扩展。这表明至关重要 缺少有关肿瘤进展的数据，例如细胞的物理和机械性能和 周围的组织。考虑到癌症的复杂性是一种全身性疾病，最近很高的期望 已经提出，通过结合生物学，化学，数学，工程学，一种跨学科的方法 大数据和生物医学的物理学将导致收敛肿瘤学。不属于的现象 直接由特定分子触发的方法只能通过收敛方法来理解。部分支持是 要求进行“癌症物理科学”戈登研究会议（GRC）的第三次迭代 于2023年2月5日至10日举行，以及“癌症的物理科学”戈登研究研讨会的第二次迭代 （GRS）将于2023年2月4日至5日举行。这些会议将在GRC选择的会议酒店举行（ 德克萨斯州加尔维斯顿的Grand Galvez）。会议承诺将为演讲提供论坛 讨论有关多学科方法的最新进展和新思想及其在 了解基本的癌症进展以及发展潜在的翻译观点。 该GRC的长期目标是促进开发和使用方法，以扩展 可以成功解决的癌症靶标。这些将通过以下目的实现： （1）审查癌症定量方法的进步并确定挑战。 （2）训练下一代科学家，以定量研究潜在的物理机制 驱动癌症（GRS）并促进多样性参与。 （3）促进新的合作，重点是使用定量方法来应对挑战 癌症。 会议主题是根据对该领域的主要科学挑战的潜在影响而选择的 以及他们在跨学科方法中的实力。专注于在背景，舞台上给潜水员的声音 职业和纪律将是我们计划的核心。我们将引入包容性心态作为主要的心态 专注于更好地训练和培养下一代多学科癌症研究人员。海报 会议将为各级调查人员之间的参与提供足够的机会。我们预料到这一点 在本次会议期间的科学互动将以重要的方式影响癌症研究，并导致 建立生产性的多学科研究合作。 这次会议将集体强调过去四年的重大进展，并催化 开发新概念和协同作用，旨在塑造癌症中物理科学的未来 并允许我们整体研究现象。最终，这些系统之间的动态相互作用 驱动肿瘤倡议，进展，转移性扩散和疾病复发的力。应用程序 癌症分子，细胞，组织和器官水平基础的物理和数学基础的基础 揭示了疾病期间的基本变化，这些变化反映在癌症类型和阶段之间。在这个 会议，我们将听取专家的来信，将物理科学应用于癌症，以研究各种疾病现象 尺度和系统。