Portable and modular UDS Data Collection software to increase collaboration and engagement of Alzheimer’s Disease Research Center research software engineers

便携式模块化 UDS 数据收集软件，可增强阿尔茨海默病研究中心研究软件工程师的协作和参与

• 批准号: 10608722
• 负责人: LINDA J VAN ELDIK
• 金额: $ 22.93万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608722
• 关键词: Administrative Supplement; Adoption; Alzheimer' s Disease; Alzheimer' s disease model; Biological Markers; Biometry; Clinical; Code; Cognitive; Cognitive aging; Collaborations; Collection; Communities; Community Developments; Computer software; Data; Data Collection; Data Sources; Data Store; Database Management Systems; Decision Making; Dementia; Development; Disease; Ecosystem; Education; Elderly; Environment; Etiology; Funding; Genetic; Goals; Growth; Heterogeneity; Human Resources; Hybrids; Image; Impairment; Individual; Infrastructure; Investments; Kentucky; Libraries; Longitudinal Studies; Longitudinal cohort; Maintenance; Mission; Modeling; Modernization; Pathogenicity; Pathology; Research; Resources; Secure; Software Engineering; Software Tools; Technology; Testing; Universities; Work; cloud based; community center; community engagement; data access; data management; driving force; experience; flexibility; improved; infancy; innovation; interoperability; neuroimaging; neuropathology; normal aging; open data; open source; operation; outreach; portability; pre-clinical; programs; recruit; research study; response; software development; statistics; success; tool; web app; Administrative Supplement; Adoption; Alzheimer' s Disease; Alzheimer' s disease model; Biological Markers; Biometry; Clinical; Code; Cognitive; Cognitive aging; Collaborations; Collection; Communities; Community Developments; Computer software; Data; Data Collection; Data Sources; Data Store; Database Management Systems; Decision Making; Dementia; Development; Disease; Ecosystem; Education; Elderly; Environment; Etiology; Funding; Genetic; Goals; Growth; Heterogeneity; Human Resources; Hybrids; Image; Impairment; Individual; Infrastructure; Investments; Kentucky; Libraries; Longitudinal Studies; Longitudinal cohort; Maintenance; Mission; Modeling; Modernization; Pathogenicity; Pathology; Research; Resources; Secure; Software Engineering; Software Tools; Technology; Testing; Universities; Work; cloud based; community center; community engagement; data access; data management; driving force; experience; flexibility; improved; infancy; innovation; interoperability; neuroimaging; neuropathology; normal aging; open data; open source; operation; outreach; portability; pre-clinical; programs; recruit; research study; response; software development; statistics; success; tool; web app

PROJECT SUMMARY This is an administrative supplement application to the University of Kentucky Alzheimer’s Disease Research Center (UK-ADRC), submitted in response to NOT-OD-22-068, Administrative Supplements to Support Enhancement of Software Tools for Open Science. We are requesting funds to support the Data Management and Statistics (DMS) Core for data management activities relevant to NOT-OD-22-068. The UK-ADRC is an experienced and collaborative Center whose principal mission is to provide an environment and core resources that catalyze innovative research, outreach, education and clinical programs. Our overarching theme is Transitions from Normal to Late-Life Multi-Etiology Dementia. Our well-characterized, longitudinal cohort and historically strong neuropathology program focused on normal aging, preclinical disease states and early cognitive transitions have been central to our success in defining early pathogenic mechanisms underlying the transitions from normal cognitive aging to impairment. In addition, these efforts have been a driving force in our recognition of the heterogeneity and multiple pathologies that characterize late-life dementia. Our strong and active DMS Core is critical for integration of the ADRC Cores and is vital to the success of the UK-ADRC. Over the years, ADRC data collection has grown in scope, scale, and complexity to include not just collection of UDS data but a multitude of parallel data collections covering clinical, imaging, biospecimens, biomarker, and biometric data across the ADRC longitudinal cohort as well as other related research studies. The DMS Core has developed a cloud-based .NET Core MVC web application to collect UDS data in a way that works within an existing enterprise ecosystem with varied interconnected data sources and stores. We propose here enhancements to the codebase that include refactoring the codebase for interoperability, adding automated testing tools for sustainable community engagement, and implementing containerization to facilitate a wide range of deployment environments. The specific aims of the supplement are: AIM 1: Increase software interoperability by refactoring current codebase to decouple the data access layer from the presentation layer. AIM 2: Promote ADRC developer community engagement by adding automated testing tools to prepare codebase for external contributions. AIM 3: Increase portability and ADRC adoption of software through containerization. These software tools will be extremely useful not just to the UK-ADRC, but to the national ADRC community by enhancing the ability to integrate data within a robust large-scale research environment.

项目摘要 这是对肯塔基大学阿尔茨海默氏病研究的行政补充申请 中心（UK-ADRC），响应于NOT-OD-22-068的行政补品，以支持 增强开放科学的软件工具。我们要求资金支持数据管理 与NOT-OD-22-068相关的数据管理活动的统计核心（DMS）核心。英国-ADRC是 经验丰富和协作的中心，其主要使命是提供环境和核心资源 这催化了创新的研究，外展，教育和临床计划。我们的总体主题是 从正常生命到多性痴呆症的过渡。我们的纵向纵向队列 历史上强烈的神经病理学计划着重于正常衰老，临床前疾病状态和早期 认知转变是我们在定义早期致病机制方面成功的核心 从正常认知衰老到损害的过渡。此外，这些努力一直是我们的驱动力 识别表征晚年痴呆症的异质性和多种病理。我们的坚强和 Active DMS核心对于整合ADRC核心至关重要，对于英国-ADRC的成功至关重要。超过 多年来，ADRC数据收集的年份范围，比例和复杂性不仅包括收集 UDS数据，但涵盖临床成像，生物测量，生物标志物和 ADRC纵向队列以及其他相关研究的生物识别数据。 DMS核心 已经开发了一个基于云 现有的企业生态系统，具有不同的互连数据源和商店。我们在这里提出建议 对代码库的增强功能，其中包括重构代码库以进行互操作性，添加自动化 测试可持续社区参与的工具，并实施集装箱，以促进广泛的 部署环境范围。 补充的具体目的是： AIM 1：通过重构当前代码库将数据访问层解除来增加软件互操作性 从演示层。 目标2：通过添加自动测试工具来促进ADRC开发人员社区参与 外部贡献的代码库。 目标3：通过容器化增加软件的可移植性和ADRC采用。 这些软件工具将不仅对英国ADRC非常有用，而且对国家ADRC社区非常有用 增强了将数据集成到强大的大规模研究环境中的能力。