Categorical and dimensional investigations of dynamic functional connectivity and behavior during response inhibition in children with and without ADHD

患有和不患有多动症的儿童在反应抑制过程中动态功能连接和行为的分类和维度研究

• 批准号: 10606133
• 负责人: Arianna Dame Cascone
• 金额: $ 3.82万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10606133
• 关键词: Adult; Affect; Age; Algorithms; Attention deficit hyperactivity disorder; Behavior; Behavioral; Behavioral Symptoms; Brain; Categories; Child; Childhood; Classification Scheme; Clinical; Communities; Data; Detection; Development; Diagnosis; Diagnostic; Dimensions; Disease; Exhibits; Functional Magnetic Resonance Imaging; Future; Goals; Heterogeneity; Hyperactivity; Impairment; Impulsivity; Individual; Intervention; Investigation; Link; Literature; Measures; Methods; National Research Service Awards; Neurobiology; Neurodevelopmental Disorder; Neuronal Dysfunction; Outcome; Participant; Pattern; Performance; Phenotype; Population; Process; Reaction Time; Research; Research Personnel; Rest; Risk; Sampling; Social outcome; Subgroup; Symptoms; Techniques; Thinking; Training; Transcend; United States; Variant; base; clinical diagnosis; clinically relevant; cognitive control; emotional symptom; experience; improved; inattention; novel; pre-doctoral; relating to nervous system; response; Adult; Affect; Age; Algorithms; Attention deficit hyperactivity disorder; Behavior; Behavioral; Behavioral Symptoms; Brain; Categories; Child; Childhood; Classification Scheme; Clinical; Communities; Data; Detection; Development; Diagnosis; Diagnostic; Dimensions; Disease; Exhibits; Functional Magnetic Resonance Imaging; Future; Goals; Heterogeneity; Hyperactivity; Impairment; Impulsivity; Individual; Intervention; Investigation; Link; Literature; Measures; Methods; National Research Service Awards; Neurobiology; Neurodevelopmental Disorder; Neuronal Dysfunction; Outcome; Participant; Pattern; Performance; Phenotype; Population; Process; Reaction Time; Research; Research Personnel; Rest; Risk; Sampling; Social outcome; Subgroup; Symptoms; Techniques; Thinking; Training; Transcend; United States; Variant; base; clinical diagnosis; clinically relevant; cognitive control; emotional symptom; experience; improved; inattention; novel; pre-doctoral; relating to nervous system; response

PROJECT SUMMARY Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder of childhood and affects approximately 5-10% of children worldwide. ADHD is characterized by core symptoms of inattention, hyperactivity, and impulsivity, though there is much heterogeneity in the ADHD phenotype. Much research into the specific neural dysfunction underlying the pediatric ADHD phenotype has employed categorical approaches, comparing children with ADHD to typically developing children. However, children with and without clinical ADHD diagnoses experience a wide range of ADHD-related symptoms. As individuals with ADHD symptom burden, regardless of diagnosis, are at risk for negative-long term outcomes, the proposed studies will investigate the ADHD phenotype categorically and dimensionally to increase the understanding of the neural substrates of ADHD symptom burden in clinical and nonclinical populations. As such, the proposed research will use a novel dynamic functional connectivity method to determine whether task-based variations in functional connectivity and behavior differ in children with ADHD and in children without ADHD (categorical approach; Specific Aim 1), and whether there are relationships among ADHD symptom burden, functional connectivity dynamics, and behavior in a large sample of children with continuous ADHD-related symptom measures (dimensional approach; Specific Aim 2). Exploratory Aim 3 will further probe the heterogeneity in ADHD symptom burden that exists within and across ADHD by using a community detection algorithm to identify subgroupings of individuals with and without ADHD that exhibit similar symptom profiles. Together, the three aims of the proposed research will contribute to the development of strategies that allow for the identification of individuals who may benefit from treatment and intervention for ADHD symptom burden across diagnostic categories.

项目摘要 注意缺陷/多动症（ADHD）是最常见的神经发育障碍 童年时期，全世界约有5-10％的儿童影响。多动症的特征是核心症状 尽管ADHD表型中存在很多异质性，但注意力不集中，多动症和冲动性。很多 小儿多动症表型基础的特定神经功能障碍的研究已采用分类 方法，将多动症儿童与通常成长的儿童进行比较。但是，有和没有的孩子 临床ADHD诊断经历了广泛的ADHD相关症状。作为多动症的人 症状负担，无论诊断如何 明确和尺寸研究ADHD表型以增加对神经的理解 临床和非临床人群中ADHD症状负担的底物。因此，拟议的研究将 使用一种新型的动态功能连接方法来确定功能中是否基于任务的变化 ADHD儿童和无多动症儿童的连通性和行为不同（分类方法； 特定目标1）以及多动症症状负担之间是否存在关系，功能连接性 与ADHD相关症状措施的大量儿童样本中的动态和行为 （维度方法；特定目标2）。探索目标3将进一步探测多动症症状的异质性 通过使用社区检测算法来识别子组，在多动症内部和整个多动症中存在的负担 具有和没有多动症的个体表现出相似的症状特征。在一起，三个目标 拟议的研究将有助于制定允许个人识别的战略 谁可能会受益于跨诊断类别的ADHD症状负担的治疗和干预措施。