2023 Mammalian DNA Repair GRC & GRS

2023 哺乳动物 DNA 修复 GRC

基本信息

批准号：
10607587
负责人：
Patricia L Opresko
金额：
$ 1.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-02 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10607587
关键词：
Address Age Aging Aldehydes Alkylation Atmosphere CRISPR/Cas technology California Cell physiology Cells Chemicals Clinical Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities DNA DNA Damage DNA Repair DNA Repair Pathway DNA biosynthesis Defect Degenerative Disorder Development Disease Eating Environmental Exposure Exposure to Faculty Female Fostering Functional disorder Gender Genetic Transcription Genome Genome Stability Genome engineering Genomic Instability Health Human Human Genome Immune signaling Immunotherapy Industry Intervention Knowledge Leadership Learning Lesion Maintenance Malignant Neoplasms Mediating Metabolism Methods Mitosis Modeling Modification Neurodegenerative Disorders Normal Cell Oral Oxygen Participant Pathway interactions Postdoctoral Fellow Premature aging syndrome Radiation Research Research Personnel Science Scientist Series Source Sunlight Time Woman career development combustion product experience frontier graduate student human disease inhibitor innovation interest meetings member posters programs repaired response scientific atmosphere social symposium targeted treatment tumor

项目摘要

Project Abstract/Summary This 5-day GRC and 2-day GRS conference is focused on the research of genomic instability and its implications in human diseases and therapies. Exposures environmental and endogenous source of DNA damage produce thousands to over a million lesions and chemical modifications to the genome per cell every day. Common environmental sources of DNA damage include sunlight, radiation, aldehydes, and combustion byproducts, while endogenous sources include oxygen metabolism, metabolites, alkylation and dysregulation of DNA replication, transcription and mitosis. In normal cells, a multitude of DNA repair and DNA damage response mechanisms successfully operate to maintain genomic stability. However, defects in these mechanisms can result in diseases ranging from rare developmental and premature aging syndromes to common cancers. This Mammalian DNA Repair Gordon Research Conference (GRC) and associated Gordon Research Seminar (GRS) will bring together diverse researchers studying the mechanisms that protect the genome against DNA damage, and the consequences for human health when these pathways fail. Additionally, this conference will promote discussions on how to inhibit DNA damage response and repair mechanisms, or leverage dysfunction in these mechanisms, to selectively target tumors in a more efficacious and less toxic manner. The objectives are: 1) To expose researchers at all levels (faculty, researchers from industry, postdoctoral fellows, and graduate students) to new frontiers and innovative methods in this rapidly progressing research field. 2) To provide opportunities for young scientists to network and practice presenting their research. 3) To generate an atmosphere of inclusion and rigor that encourages the exchange of scientific ideas that may foster collaborations or spur new innovation. 4) To provide formal and informal career development opportunities. We will achieve these objectives by assembling diverse speakers and poster presenters. 44% of the invited speakers in the GRC are women and we expect approximately 50% of the GRS speakers be female trainees. This GRC/GRS is notable compared to meetings on similar topics for the amount of unpublished research that is presented, as well as the extensive informal discussion time during sessions, meals, and free time.

项目摘要/总结这次为期 5 天的 GRC 和 2 天的 GRS 会议重点研究基因组不稳定性及其影响对人类疾病和治疗的影响。暴露环境和内源性 DNA 来源损伤每次都会对每个细胞的基因组产生数千甚至超过一百万个损伤和化学修饰天。 DNA 损伤的常见环境来源包括阳光、辐射、醛类和燃烧副产物，而内源性来源包括氧代谢、代谢物、烷基化和失调 DNA 复制、转录和有丝分裂。在正常细胞中，存在大量的 DNA 修复和 DNA 损伤反应机制成功运作以维持基因组稳定性。然而，这些缺陷机制可能导致各种疾病，从罕见的发育和早衰综合症到常见癌症。本次哺乳动物 DNA 修复戈登研究会议 (GRC) 及相关戈登研究研讨会（GRS）将汇集不同的研究人员，研究保护环境的机制基因组对抗 DNA 损伤，以及这些途径失效时对人类健康的影响。此外，本次会议还将推动如何抑制DNA损伤反应和修复的讨论机制，或利用这些机制中的功能障碍，以更有效的方式选择性地靶向肿瘤且毒性较小的方式。目标是： 1) 让各个级别的研究人员（教师、来自不同领域的研究人员）接触行业、博士后研究员和研究生）在这个迅速发展的新领域和创新方法不断进步的研究领域。 2) 为年轻科学家提供交流和练习演讲的机会他们的研究。 3）营造包容和严谨的氛围，鼓励科学交流可以促进合作或刺激新创新的想法。 4）提供正式和非正式的职业发展机会。我们将通过聚集不同的演讲者和海报来实现这些目标主持人。 GRC 中受邀演讲者中有 44% 是女性，我们预计 GRS 中的这一比例约为 50% 演讲者为女学员。与类似主题的会议相比，本次 GRC/GRS 值得注意所提出的未发表的研究，以及会议期间广泛的非正式讨论时间，吃饭，还有空闲时间。