Knee evaluation under mechanical loading by cones ultrashort echo time MR imaging

通过锥体超短回波时间 MR 成像对机械负荷下的膝关节进行评估

• 批准号: 10602431
• 负责人: saeed jerban
• 金额: $ 12.04万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-05 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10602431
• 关键词: 3-Dimensional; Acceleration; Affect; Age; Anatomy; Body Weight; Body mass index; Bone structure; Cadaver; Cartilage; Chemicals; Clinical; Cone; Defect; Degenerative polyarthritis; Development Plans; Devices; Diagnosis; Early Diagnosis; Evaluation; Fiber; Gender; Goals; Human; Image; Imaging Techniques; Joints; Knee; Knee Osteoarthritis; Knee joint; Magic; Magnetic Resonance Imaging; Manuals; Measurement; Measures; Mechanical Stress; Mechanics; Meniscus structure of joint; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Morphology; Pain; Patients; Pattern; Phase; Physiological; Positioning Attribute; Postdoctoral Fellow; Preparation; Process; Property; Radiology Specialty; Research; Research Personnel; Rest; Scanning; Signal Transduction; Specimen; Stretching; Structure; Supine Position; Techniques; Time; Tissues; Training; United States National Institutes of Health; Variant; bone; career development; clinical imaging; design; experience; hamstring; improved; in vivo; mechanical load; mechanical properties; multidisciplinary; novel; quadriceps muscle; reconstruction; research study; substantia spongiosa; ward

ABSTRACT: Dr. Jerban is postdoctoral researcher with a multidisciplinary background who is proposing a research entitled “Knee evaluation under mechanical loading by Cones Ultrashort Echo Time MR imaging” through NIH K01 program under the mentorship of Drs. Christine Chung, Samuel Ward, and Jiang Du to develop into an independent investigator. Improving the osteoarthritis (OA) diagnosis at early stage using Magnetic Resonance Imaging (MRI) techniques are limited by three main barriers. First, the current clinical MRI techniques do not acquire signal from short T2 tissues, such as the meniscus and the deep layer of cartilage. Second, most Ultrashort Echo Time (UTE) MRI techniques that can acquire signal from short T2 tissues are orientation sensitive. Third, knee MRI is routinely performed on joints at rest, which incompletely mimics the actual physiological condition, particularly, the loading aspects. Recently, we have developed new UTE-MRI techniques (UTE-Ad-T1ρ and UTE-MT) that are not orientation-sensitive and that are designed specifically for scanning short T2 tissues of the knee. We have hypothesized that scanning knee joints during mechanical load application using these orientation-insensitive techniques will reveal the mechanical properties of the joint tissues, which in turn will help to distinguish between healthy, early stage and mild OA knee joints. We also hypothesized bone remodels in order to enhance the support to cartilage/menisci regions with defected cartilage, which complementarily confirms the early stage OA diagnosis. A research study is proposed to cover three main specific aims: dissected specimens’ study, whole knee cadaveric study, and in vivo study. First, we will accelerate the UTE-MRI techniques and then will investigate their variation patterns in healthy and moderate OA human cartilage/menisci specimens during the loading/unloading process. We will also assess the supporting bone specimens to compare with UTE variation patterns in cartilages/menisci under loading. Second, we will build and verify a pneumatic loading setup for the cadaver whole knee study, which is meant to assess the temporal variation of knees under a set of loading and unloading steps. Then the UTE-MRI variation patterns in joints from healthy, mild OA, and moderate OA groups during the loading/unloading process will be investigated. Third, we will design and build a separate loading device to perform the in vivo phase of the study. We will determine if in vivo UTE-MRI variation pattern under loading are distinct for early stage OA patients, and if UTE-MRI/CT can detect an improved bone structure and properties for early stage and mild OA knees. The feasibility of accelerating our orientation-insensitive UTE-MRI techniques and the significant sensitivity of our techniques to changes in knee tissues during mechanical load application (using an initial design of loading device) have been demonstrated in our preliminary results. Dr. Jerban and his mentors, Drs. Chung, Ward, and Du, have designed a detailed training plan and assembled a strong team of advisors to guide Dr. Jerban through his career development plan towards becoming an independent investigator.

抽象的： Jerban博士是具有多学科背景的博士后研究员，他提出了一项题为的研究 NIH的“锥度超时回波时间MR成像下的膝盖评估” K01计划在Drs的心态下。克里斯汀·钟（Christine Chung），塞缪尔·沃德（Samuel Ward）和江杜（Jiang du）发展成一个 独立研究者。使用磁共振在早期诊断的骨关节炎（OA）诊断 成像（MRI）技术受到三个主要障碍的限制。首先，当前的临床MRI技术不 从短T2组织中获取信号，例如半月板和软骨深层。第二，大多数 可以从短t2组织中获取信号的Ultrashort Echo时间（UTE）MRI技术是方向 敏感的。第三，膝盖MRI通常在静止的关节上进行，这并不完全模拟实际 生理状况，特别是负载方面。最近，我们开发了新的UTE-MRI技术 （UTE-AD-T1ρ和UTE-MT）非方向敏感，专门设计用于扫描短 膝盖的T2组织。我们假设在机械负载期间扫描膝关节 使用这些取向不敏感的技术将揭示关节时机的机械性能， 转弯将有助于区分健康，早期和轻度OA膝关节。我们还假设骨头 改建以增强对软骨的软骨/半月板区域的支撑 完整地确认了早期OA诊断。提出了一项研究涵盖三个主要的研究 具体目的：解剖的物种研究，全膝盖尸体研究和体内研究。首先，我们将加速 UTE-MRI技术，然后将研究其健康和中等的OA人类的变异模式 在加载/卸载过程中，软骨/弯月板标本。我们还将评估支撑骨 与软骨/半月板在负载下的UTE变化模式相比的规格。其次，我们将建造和 验证用于尸体整个膝盖研究的气动加载设置，该研究旨在评估临时性 一组负载和卸载步骤下膝盖的变化。然后是关节中的UTE-MRI变化模式 在加载/卸载过程中，健康，轻度的OA和中等的OA组将进行研究。第三，我们 将设计和建造一个单独的加载装置，以执行研究的体内阶段。我们将确定是否在 负载下的Vivo UTE-MRI变异模式对于早期OA患者而言是不同的，如果UTE-MRI/CT可以 检测早期和轻度OA膝盖的改善骨结构和特性。可行性 加速我们对方向不敏感的UTE-MRI技术以及我们对技术的显着敏感性 机械负载期间膝盖组织的变化（使用加载装置的初始设计）是 在我们的初步结果中证明。 Jerban博士及其导师Chung，Ward和Du博士设计了 详细的培训计划，并组建了一支强大的顾问团队，以指导Jerban博士的职业生涯 发展计划成为独立研究者。