Developmental Research Program

发展研究计划

• 批准号: 10601409
• 负责人: ULRIKE PETERS
• 金额: $ 4.74万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601409
• 关键词: Developmental; Research; Program; Developmental; Research; Program

Project Summary/Abstract of the Development Research Program The Developmental Research Program (DRP) will provide key support to develop novel translational early-phase Projects in the area of cancer disparities that, ultimately, will contribute to the reduction in the morbidity and mortality of cancer among medically underserved populations. In line with the overall goals of our Translational Research Program in Colorectal Cancer Disparities. The DRP will foster new collaborations between participating institutions and initiate collaborations with other SPOREs and Disparities P20’s. Additionally, our Career Enhancement Program (operated through our Administrative Core) will encourage early career investigators, particularly those from racially/ethnically diverse backgrounds, to apply to the DRP. Our goal is to fund Developmental Research Projects encompassing a range of translational cancer disparities research, including molecular biology, epidemiology (primary and secondary prevention), early detection, prognosis, therapeutics, and survivorship. To achieve this goal, we will identify promising translational cancer disparities Research Projects through broad solicitation (Aim 1). We will encourage early and senior investigators to collaborate across multiple disciplines. New ideas will be solicited on an annual basis by broadly advertising pilot funding and targeted engagement with promising faculty. Aim 2 will focus on rigorous and balanced scientific review of DRP proposals. We will convene an expert panel encompassing a broad range of scientific disciplines and also include participation from our Community Advisory Board. We will follow the National Institutes of Health SPORE guidelines for these reviews. In addition to financial support, funded DRP Projects will receive strong infrastructure support and access to biospecimens and expertise related to novel technologies through our Administrative and Biospecimen and Pathology Cores (Aim 3). With our generous institutional matching support we will award $100,000 of funding to DRP projects annually and anticipate that each year we will fund about 3 one-year projects. The progress of all DRP projects will be monitored regularly with respect to achieving their specific aims and milestones using clearly defined evaluation criteria (Aim 4). Of particular interest will be the potential of each project to advance to a full SPORE Project. We will also track long-term reportable outcomes of each project such as peer-reviewed manuscripts, oral presentations and grant funding.

项目摘要/开发研究计划的摘要 发展研究计划（DRP）将提供关键的支持，以发展新颖的翻译 癌症分布领域的早期项目最终将有助于减少 在医学上服务不足的人群中，癌症的发病率和死亡率。符合总体目标 我们关于结直肠癌差异的转化研究计划。 DRP将促进新的合作 在参与机构与其他孢子和差距P20之间的合作之间。 此外，我们的职业增强计划（通过我们的行政核心运营）将鼓励 早期的职业调查人员，特别是来自大致/种族不同背景的调查人员，适用于DRP。 我们的目标是资助涵盖一系列转化癌差异的发展研究项目 研究，包括分子生物学，流行病学（原发性和二级预防），早期检测， 预后，治疗和生存。为了实现这一目标，我们将确定有希望的转化癌 差距研究项目通过广泛的招标（AIM 1）。我们将鼓励早期和高级 调查人员跨多个学科进行合作。新想法将每年通过 AIM 2将重点放在严格的 以及对DRP建议的平衡科学综述。我们将召集一个专家小组，包括广泛的 一系列科学学科，还包括我们社区顾问委员会的参与。我们将跟随 这些评论的国家卫生孢子指南。除了经济支持外，还资助 DRP项目将获得强大的基础设施支持，并获得与生物测量的访问以及与之相关的专业知识 通过我们的行政和生物测量和病理核心的新技术（AIM 3）。与我们的 慷慨的机构匹配支持我们将每年向DRP项目授予100,000美元的资金，并 预计每年我们将资助约3个一年的项目。所有DRP项目的进度将是 使用明确定义 评估标准（AIM 4）。特别感兴趣 项目。我们还将跟踪每个项目的长期可报告结果，例如同行评审的手稿， 口头演示和授予资金。