Kansas Center for Metabolism and Obesity REsearch (KC-MORE)

堪萨斯代谢和肥胖研究中心 (KC-MORE)

• 批准号: 10598012
• 负责人: John P Thyfault
• 金额: $ 232万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598012
• 关键词: Acute Pain; Adolescent; Adult; Affect; Aging; Anxiety; Area; Award; Basic Science; Behavior; Bioenergetics; Bioinformatics; Blood; Body Weight decreased; COVID-19; Cells; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Research; Collaborations; Communities; Development; Diabetes Mellitus; Disease; Eating; Education; Energy Metabolism; Foundations; Funding; Future; Goals; Growth; Health; Home; Human; Hypertension; Incidence; Infection; Infrastructure; Institution; Interdisciplinary Study; Internal Medicine; Isotopes; Kansas; Kidney Diseases; Lead; Link; Liver diseases; Longevity; Malignant Neoplasms; Measures; Medical center; Mental Depression; Mental disorders; Mentors; Mentorship; Metabolic; Metabolic dysfunction; Metabolism; Mitochondria; Modern 1601-history; Neurosciences; Obesity; Obesity Epidemic; Obesity associated disease; Outcome; Pathology; Persons; Phase; Physical activity; Physiology; Population; Population Heterogeneity; Predisposition; Prevention; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Rodent; Rodent Model; Role; Rural Community; Series; Syndrome; Talents; Time; Tissues; Translational Research; United States National Institutes of Health; Universities; Weight; Work; body system; career; career development; chronic pain; combat; energy balance; faculty support; fatty liver disease; human subject; improved; metabolic phenotype; multidisciplinary; neuroregulation; next generation; nutrition; obese patients; obesity prevention; obesity treatment; precision medicine; prevent; programs; recruit; rural area; synergism; translational research program; urban area; Acute Pain; Adolescent; Adult; Affect; Aging; Anxiety; Area; Award; Basic Science; Behavior; Bioenergetics; Bioinformatics; Blood; Body Weight decreased; COVID-19; Cells; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Research; Collaborations; Communities; Development; Diabetes Mellitus; Disease; Eating; Education; Energy Metabolism; Foundations; Funding; Future; Goals; Growth; Health; Home; Human; Hypertension; Incidence; Infection; Infrastructure; Institution; Interdisciplinary Study; Internal Medicine; Isotopes; Kansas; Kidney Diseases; Lead; Link; Liver diseases; Longevity; Malignant Neoplasms; Measures; Medical center; Mental Depression; Mental disorders; Mentors; Mentorship; Metabolic; Metabolic dysfunction; Metabolism; Mitochondria; Modern 1601-history; Neurosciences; Obesity; Obesity Epidemic; Obesity associated disease; Outcome; Pathology; Persons; Phase; Physical activity; Physiology; Population; Population Heterogeneity; Predisposition; Prevention; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Rodent; Rodent Model; Role; Rural Community; Series; Syndrome; Talents; Time; Tissues; Translational Research; United States National Institutes of Health; Universities; Weight; Work; body system; career; career development; chronic pain; combat; energy balance; faculty support; fatty liver disease; human subject; improved; metabolic phenotype; multidisciplinary; neuroregulation; next generation; nutrition; obese patients; obesity prevention; obesity treatment; precision medicine; prevent; programs; recruit; rural area; synergism; translational research program; urban area

CENTER OVERALL: PROJECT SUMMARY This COBRE proposal seeks to establish the Kansas Center for Metabolism and Obesity REsearch (KC-MORE) which will unify investigators from multiple departments and research centers at the University of Kansas Medical Center to focus research on the pathology of obesity, metabolic dysfunction, and obesity-related disease. Obesity is a critical problem that is harming the health of people in Kansas as well as the entire U.S. New research-driven solutions and therapies are needed to prevent and treat obesity, investigate metabolic signatures that underly obesity, and examine mechanisms by which obesity initiates chronic disease. The KC- MORE will serve to merge these areas of focus by (1) creating a shared intellectual home for obesity-related researchers through a common educational and seminar program, (2) providing funding and mentorship for early stage obesity-related investigators to establish independent research careers, (3) establishing scientific cores to facilitate translational research of both early stage and established investigators, and (4) partnering with departments to jointly recruit new investigators to KUMC focused on themes of the KC-MORE. This central role in leading and coordinating obesity research and incentivizing future resources and recruitment will allow KUMC to synergize efforts and form multi-disciplinary collaborations on obesity, metabolism, and obesity-induced disease research in ways that would not occur without COBRE funding. The KC-MORE will be led by two multi- PIs, Drs. Steven Weinman and John Thyfault, and a renowned senior investigator, Dr. Joseph Donnelly who will serve as Chair of the Steering Committee and lead human energy balance research. These leaders have multi- disciplinary but complimentary expertise in basic, clinical, and translational research. Phase 1 of the Center will support the development of four Research Project Leaders (RPLs) with studies on neural control of energy balance, clinical-based approaches to weight loss in rural communities, and basic mechanisms of obesity-related fatty liver disease and hypertension. KC-MORE will also administer a Pilot Awards Program to develop additional KC-MORE researchers. The KC-MORE will lead 3 new scientific cores that provide a foundation for translational research capabilities (the Metabolism (MET) core, the Cells, Tissues, Bioanalysis and Bioinformatics (CTBB) core, and the Human Energy Balance (HEB) core). The cores will support infrastructure and methodologies for the Research Project Leaders, the Pilot Award recipients, and a large pool of established obesity-related researchers on campus. A critical goal of phase 1 of the KC-MORE COBRE will be to help RPLs develop independent, R01-funded research programs. Overall, the establishment of the KC-MORE will serve to develop a translational and multi-disciplinary obesity research program that will have a significant future impact by reducing the burden of obesity-related disease conditions.

中心总体：项目摘要 这项田园提案旨在建立堪萨斯州新陈代谢和肥胖研究中心（KC-MORE） 这将统一堪萨斯大学医学多个系和研究中心的调查人员 重点研究肥胖，代谢功能障碍和与肥胖相关疾病的病理。 肥胖是一个关键问题，正在损害堪萨斯州人民以及整个美国的健康 需要研究驱动的解决方案和疗法来预防和治疗肥胖症，研究代谢 潜在肥胖的特征，并检查肥胖引发慢性疾病的机制。 KC- （1）为与肥胖有关 研究人员通过共同的教育和研讨会计划，（2）为早期提供资金和指导 与肥胖相关的研究人员建立独立的研究职业，（3）建立科学核心 促进早期和既定研究者的翻译研究，以及（4）与 将新调查人员共同招募KUMC的部门专注于KC-More的主题。这个中心角色 在领导和协调肥胖研究并激励未来的资源和招聘时，将允许KUMC 协同努力并进行肥胖，代谢和肥胖引起的多学科合作 疾病的研究以没有毛cr资金而不会发生的方式进行。 KC-More将由两个多 pis，博士。史蒂文·温曼（Steven Weinman）和约翰·泰弗（John Thyfault），以及著名的高级调查员约瑟夫·唐纳利（Joseph Donnelly）博士 担任指导委员会主席并领导人类能源平衡研究。这些领导人有多数 基础，临床和转化研究方面的纪律但免费专业知识。中心的第一阶段将 通过对能量神经控制的研究，支持四个研究项目领导者（RPLS）的发展 平衡，基于临床的农村社区体重减轻的方法，以及与肥胖有关的基本机制 脂肪肝病和高血压。 KC-More还将管理一项试验奖计划，以开发其他 KC More研究人员。 KC-More将领导3个新科学核心，为翻译提供基础 研究能力（新陈代谢（MET）核心，细胞，组织，生物分析和生物信息学（CTBB） 核心和人类能量平衡（HEB）核心）。核心将支持基础架构和方法论 研究项目负责人，飞行员奖获得者以及大量与肥胖有关的已建立 校园的研究人员。 KC-More Cobre的第1阶段的关键目标将是帮助RPL发展 独立的R01资助研究计划。总体而言，KC-More的建立将有助于发展 一个翻译和多学科的肥胖研究计划，将对未来产生重大影响 减轻与肥胖相关疾病状况的负担。