Modern approach to electrical conductivity mapping of spinal cord tissues

脊髓组织电导率测绘的现代方法

• 批准号: 10576868
• 负责人: Matthieu Kevin Chardon
• 金额: $ 20.11万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10576868
• 关键词: 3-Dimensional; Anisotropy; Behavior; Calibration; Cells; Cerebral cortex; Chest; Communities; Data; Data Set; Dependence; Electric Conductivity; Electric Stimulation; Electrodes; Electromagnetics; Electronics; Electrophysiology (science); Felis catus; Frequencies; Future; Gel; Hospitals; Human; Image; Implant; Knowledge; Left; Length; Location; Measurement; Measures; Modeling; Modernization; Needles; Neurostimulation procedures of spinal cord tissue; Pain management; Pathway interactions; Patients; Property; Research; Research Personnel; Resistance; Safety; Sampling; Signal Transduction; Source; Spinal; Spinal Cord; System; Tissues; Tungsten; Vertebral column; cell type; density; design; dorsal column; electric impedance; electrical property; experimental study; improved; neural; neuroregulation; novel; spinal cord mapping; targeted treatment; white matter

Project Summary Over 30,000 patients per year receive electrical stimulation of the spinal cord (neuromodulation) as a means of pain management. However, optimizing the delivery parameters is difficult, partly because of an extremely valuable but incomplete dataset on the electrical conductivity of spinal cord tissues. We traced the lineage of the spinal tissue electrical conductivity sources of the majority of modern electrostimulation models to a single source, Ranck 1965. The experiments within Ranck 1965 only provided two types of data: (1) bulk spinal tissue conductivity at 5, 50, 500, and 5k Hz; and (2) small volume (8 mm3) of dorsal column tissue conductivity at 5-10 Hz. Since the distribution of spinal cord cells throughout the cord is not uniform, the bulk spinal tissue conductivity sweep does not provide enough spatial information for a detailed electrical model between different sections, layers, and tissue types of the spinal cord. Our project seeks to significantly improve on Ranck 1965 by obtaining 10-1M Hz, large-volume (40 cm3), and multi-directional conductivity data for electromagnetic modeling of neuromodulation using an electronically-controlled conductivity probe array. With our findings, neuroscientists and neuromodulation researchers and designers will be able to provide more targeted therapies as a result of a more-detailed and rigorous electromagnetic spinal cord model.

项目摘要 每年超过30,000名患者接受脊髓的电刺激（神经调节）作为一种手段 疼痛管理。但是，优化交货参数很困难，部分原因是 关于脊髓组织的电导率的宝贵但不完整的数据集。我们追踪了 大多数现代电刺激模型的脊柱组织电导率来源 来源， Ranck 1965。兰克（Ranck）中的实验仅提供两种类型的数据：（1）大量脊柱组织 5、50、500和5K Hz的电导率； （2）在5-10处的背柱组织电导率的小体积（8 mm3） 赫兹。由于整个绳索的脊髓细胞的分布不均匀，因此骨骼组织 电导率扫描不提供足够的空间信息，以供不同 脊髓的切片，层和组织类型。我们的项目旨在显着改善Ranck 1965 通过获得10-1m Hz，大容量（40 cm3）和电磁多向电导率数据 使用电子控制的电导率探针阵列对神经调节进行建模。有了我们的发现， 神经科学家和神经调节研究人员和设计师将能够提供更多针对性的疗法 由于更详细，更严格的电磁脊髓模型。