Modern approach to electrical conductivity mapping of spinal cord tissues

脊髓组织电导率测绘的现代方法

• 批准号: 10576868
• 负责人: Matthieu Kevin Chardon
• 金额: $ 20.11万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10576868
• 关键词: 3-Dimensional; Anisotropy; Behavior; Calibration; Cells; Cerebral cortex; Chest; Communities; Data; Data Set; Dependence; Electric Conductivity; Electric Stimulation; Electrodes; Electromagnetics; Electronics; Electrophysiology (science); Felis catus; Frequencies; Future; Gel; Hospitals; Human; Image; Implant; Knowledge; Left; Length; Location; Measurement; Measures; Modeling; Modernization; Needles; Neurostimulation procedures of spinal cord tissue; Pain management; Pathway interactions; Patients; Property; Research; Research Personnel; Resistance; Safety; Sampling; Signal Transduction; Source; Spinal; Spinal Cord; System; Tissues; Tungsten; Vertebral column; cell type; density; design; dorsal column; electric impedance; electrical property; experimental study; improved; neural; neuroregulation; novel; spinal cord mapping; targeted treatment; white matter

Project Summary Over 30,000 patients per year receive electrical stimulation of the spinal cord (neuromodulation) as a means of pain management. However, optimizing the delivery parameters is difficult, partly because of an extremely valuable but incomplete dataset on the electrical conductivity of spinal cord tissues. We traced the lineage of the spinal tissue electrical conductivity sources of the majority of modern electrostimulation models to a single source, Ranck 1965. The experiments within Ranck 1965 only provided two types of data: (1) bulk spinal tissue conductivity at 5, 50, 500, and 5k Hz; and (2) small volume (8 mm3) of dorsal column tissue conductivity at 5-10 Hz. Since the distribution of spinal cord cells throughout the cord is not uniform, the bulk spinal tissue conductivity sweep does not provide enough spatial information for a detailed electrical model between different sections, layers, and tissue types of the spinal cord. Our project seeks to significantly improve on Ranck 1965 by obtaining 10-1M Hz, large-volume (40 cm3), and multi-directional conductivity data for electromagnetic modeling of neuromodulation using an electronically-controlled conductivity probe array. With our findings, neuroscientists and neuromodulation researchers and designers will be able to provide more targeted therapies as a result of a more-detailed and rigorous electromagnetic spinal cord model.

项目概要 每年有超过 30,000 名患者接受脊髓电刺激（神经调节）作为 疼痛管理。然而，优化交付参数很困难，部分原因是极端的 关于脊髓组织电导率的有价值但不完整的数据集。我们追溯了血统 将大多数现代电刺激模型的脊柱组织电导率源转化为单个 来源， Ranck 1965。 Ranck 1965 内的实验仅提供了两种类型的数据：（1）大块脊柱组织 5、50、500 和 5k Hz 时的电导率； (2) 小体积 (8 mm3) 背柱组织电导率为 5-10 赫兹。由于脊髓细胞在整个脊髓中的分布不均匀，因此大部分脊髓组织 电导率扫描无法为不同器件之间的详细电气模型提供足够的空间信息 脊髓的切片、层和组织类型。我们的项目力求在 Ranck 1965 的基础上显着改进 通过获取 10-1M Hz、大体积（40 cm3）、多方向的电磁电导率数据 使用电子控制电导率探针阵列进行神经调节建模。根据我们的发现， 神经科学家和神经调节研究人员和设计师将能够提供更有针对性的治疗 这是更详细、更严格的电磁脊髓模型的结果。