MB-SWIFT as a novel approach for simultaneous functional imaging of the brain and spinal cord

MB-SWIFT 作为大脑和脊髓同步功能成像的新方法

• 批准号: 10562073
• 负责人: Olli Grohn
• 金额: $ 51.62万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10562073
• 关键词: 3-Dimensional; Aging; Area; Biomedical Research; Brain; Brain imaging; Breathing; Cardiac; Central Nervous System; Cervical; Collaborations; Data; Dedications; Development; Distant; Electrophysiology (science); Evaluation; Excision; Finland; Fourier Transform; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Human; Image; Individual; Institution; Investigation; Knowledge; Location; Lumbar spinal cord structure; Magnetic Resonance Imaging; Measures; Methods; Minnesota; Modality; Morphologic artifacts; Motion; Nervous System Physiology; Neurodegenerative Disorders; Neurons; Noise; Outcome; Pain; Physiologic pulse; Physiological; Positioning Attribute; Predisposition; Procedures; Protocols documentation; Publications; RF coil; Radial; Rattus; Reproducibility; Research; Research Design; Resolution; Rest; Sampling; Scheme; Site; Slice; Spinal Cord; Spinal cord injury; Surrogate Markers; Techniques; Testing; Time; Universities; clinical application; design; imaging modality; magnetic field; member; millisecond; neuroimaging; novel; novel strategies; pre-clinical research; prevent; resilience; tool; translation to humans; virtual; 3-Dimensional; Aging; Area; Biomedical Research; Brain; Brain imaging; Breathing; Cardiac; Central Nervous System; Cervical; Collaborations; Data; Dedications; Development; Distant; Electrophysiology (science); Evaluation; Excision; Finland; Fourier Transform; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Human; Image; Individual; Institution; Investigation; Knowledge; Location; Lumbar spinal cord structure; Magnetic Resonance Imaging; Measures; Methods; Minnesota; Modality; Morphologic artifacts; Motion; Nervous System Physiology; Neurodegenerative Disorders; Neurons; Noise; Outcome; Pain; Physiologic pulse; Physiological; Positioning Attribute; Predisposition; Procedures; Protocols documentation; Publications; RF coil; Radial; Rattus; Reproducibility; Research; Research Design; Resolution; Rest; Sampling; Scheme; Site; Slice; Spinal Cord; Spinal cord injury; Surrogate Markers; Techniques; Testing; Time; Universities; clinical application; design; imaging modality; magnetic field; member; millisecond; neuroimaging; novel; novel strategies; pre-clinical research; prevent; resilience; tool; translation to humans; virtual

ABSTRACT Our goal is to establish a novel MRI approach to acquire functional MRI (fMRI) data simultaneously from brain and spinal cord. Unlike standard MRI readouts, our approach does not require a dedicated shimming procedure, as it is based on the newly developed zero echo time MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) which is inherently resilient to magnetic field inhomogeneities. Comprehensive evaluations of the central nervous system (CNS) function will tremendously benefit from this imaging modality, particularly in areas of research such as spinal cord injury, neurodegenerative diseases, pain and aging. Thus far, functional neuroimaging of the CNS has been an untapped area of research due to several technical challenges, the biggest of which is the need to efficiently shim a field of view large enough to cover both brain and spinal cord. Solutions of per-slice dynamic shimming approaches have been proposed. However, they are limited by the settling-time of eddy currents, they considerably prolong the experimental session, and they have been applied only to cover cervical (but not lower) spinal cord. Furthermore, dynamic shimming allows only inefficient sequential rather than simultaneous acquisitions of brain and spinal cord, posing additional challenges for CNS fMRI. As proven by our preliminary data, MB-SWIFT can instead image two fields of view (FOVs) at distant locations in brain and lumbar spinal cord in a true simultaneous fashion (i.e., within 1 ms of each other), thus allowing unprecedented functional imaging of the CNS that is unattainable with standard imaging modalities for fMRI. The current project is a proof-of-concept study conducted in rats, designed to first optimize the MB-SWIFT protocol including the dual RF coil and the dual FOV acquisition, then to demonstrate that fMRI of CNS with MB-SWIFT provides robust fMRI outcomes in absence of dedicated shimming solutions. Moreover, we will optimize spoke order of MB-SWIFT and post-processing pipeline for handling physiological noise, and demonstrate that MB-SWIFT provides surrogate markers of neuronal activity in spinal cord. Finally we will establish inter-subject, intra-subject and inter-site reproducibility of task-based and resting-state fMRI outcomes extracted from the CNS with dual FOV MB-SWIFT. Once completed, the study will provide an invaluable tool for pre-clinical research, and will set the stage for translation to humans.

抽象的 我们的目标是建立一种新型的MRI方法来同时从大脑中获取功能性MRI（fMRI）数据 和脊髓。与标准MRI读数不同，我们的方法不需要专用的光滑程序， 因为它基于新开发的零回波时间MRI脉冲序列，标题为“多波段扫描成像” 具有傅立叶变换（MB-SWIFT），它固有地对磁场不均匀性有弹性。 对中枢神经系统（CNS）功能的全面评估将从此受益匪浅 成像方式，特别是在研究领域，例如脊髓损伤，神经退行性疾病，疼痛 和老化。到目前为止，由于几个 技术挑战，其中最大的是需要有效地覆盖足够大的视野以覆盖 大脑和脊髓。已经提出了每片动态光滑方法的溶液。然而， 它们受涡流定居时间的限制，大大延长了实验性会议，并且 它们仅用于覆盖颈椎（但不覆盖较低）的脊髓。此外，动态的闪光允许 只有效率低下的顺序而不是同时获得大脑和脊髓，提出了其他 CNS fMRI面临的挑战。正如我们的初步数据证明的那样，MB-Swift可以图像两个视野 （FOV）在大脑和腰脊髓的遥远位置以真实的方式（即，在1 ms之内 彼此），从而允许对CNS的前所未有的功能成像，而标准是无法实现的 fMRI的成像方式。当前的项目是在大鼠中进行的概念验证研究，旨在首先 优化包括双RF线圈和双FOV采集的MB-Swift协议，然后证明 具有MB-SWIFT的中枢神经系统的fMRI在没有专用的光滑溶液的情况下提供了强大的FMRI结果。 此外，我们将优化用于处理生理学的MB-Swift和后处理管道的辐条顺序 噪声，并证明MB-SWIFT提供了脊髓中神经元活性的替代标记。最后 我们将建立基于任务和静止状态fMRI的主体间，主体内和地点可重复性 用双FOV MB-SWIFT从中枢神经系统中提取的结果。完成后，研究将提供 可用于临床前研究的宝贵工具，并将为翻译为人类的阶段。