Nutrition and Physical Activity Assessment Study - Assessment of Dietary Supplements

营养和身体活动评估研究 - 膳食补充剂的评估

• 批准号: 10271554
• 负责人: JOHANNA W LAMPE
• 金额: $ 17.56万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-08 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10271554
• 关键词: Address; Administrative Supplement; Affect; Beta Carotene; Biological Markers; Blood; Categories; Chronic Disease; Classification; Collection; Consumption; Data; Diet; Dietary Assessment; Dietary Practices; Dose; Eating; Fasting; Folic Acid; Food; Food Patterns; Food Supplements; Funding; Goals; Intake; Lutein; Mass Fragmentography; Measures; Modeling; Nutrient; Nutritional; Observational Study; Participant; Physical activity; Protocols documentation; Records; Reporting; Research; Serum; Spottings; Text; Urine; Validation; Variant; Woman; Women' s Health; Work; alpha Tocopherol; alpha-carotene; biomarker discovery; dietary; dietary supplements; disorder risk; doubly-labeled water; feeding; gamma-Tocopherol; improved; lycopene; metabolomics; novel; nutrition; nutritional epidemiology; parent grant; preservation; response; study population; zeaxanthin

ABSTRACT We are responding to PA-20-227 “Administrative Supplement for Research on Dietary Supplements” to support dietary supplement-related analysis of previously collected data on our parent grant R01 CA119171, “Nutrition and Physical Activity Assessment Study,” (NPAAS). The goal of the NPAAS parent grant is to discover and utilize novel, reliable biomarkers of nutrients, foods and dietary patterns to enhance the field of nutritional epidemiology and the understanding diet-related chronic disease risk. In previous funding cycles we implemented dietary assessment, doubly labeled water (DLW) and biospecimen collection protocols (2006- 2010) in 450 participants in the Women’s Health Initiative (WHI) Observational Study (NPAAS-OS). We next conducted a novel controlled feeding study in 153 WHI participants (2011-2014), in which each participant was provided a diet approximating her usual diet so that blood and urine measures would stabilize quickly and intake variations in the study population would be preserved, and we implemented the DLW and biospecimen collection protocols in NPAAS-FS to match NPAAS-OS. In both studies, fasting blood and urine (24-h and spot) were analyzed for nutrients (B-12, folate, alpha- & beta-carotene, lutein + zeaxanthin, lycopene, alpha- and gamma tocopherol) and metabolomics by 3 platforms: GC-MS, LC-MS and NMR. Dietary supplement intake data were also collected; 68% of women in the NPAAS-OS and 88% in the NPAAS-FS reported using supplements. The work proposed for this Administrative Supplement will make use of these previously collected data. The Supplement specific aims are: ) To create constructed variables from the open-ended text field dietary supplement records in the NPAAS-FS multiple day food records; 2) To describe common categories of dietary supplement exposure in NPAAS participants using the new constructed variables from NPAAS-FS and NPAAS-OS; 3) To characterize the contribution of specific categories of dietary supplement use to the overall associations between consumed nutrients and dietary biomarkers in NPAAS-FS and to apply the models in NPAAS-OS; and 4) To evaluate the utility of combinations of established nutrient biomarkers and serum and urine metabolomics profiles to characterize nutrient intakes from food and dietary supplements in the NPAAS-FS and NPAAS-OS. To date, the dietary supplement data for NPAAS-FS and NPAAS-OS have not been fully categorized. Further classification of the supplement data into useable categories (single supplements, multi-ingredients, other combinations) may be important because our initial work in the NPAAS- FS showed that a binary (yes/no) dietary supplement use variable was an important predictor in analyses of the association between concentration biomarkers and nutrient intake. Use of only a binary variable for such a purpose is very limiting. In response, this Administrative Supplement will lead to estimates of total nutrient exposure from food + supplements thereby enhancing nutritional biomarker discovery, validation and application. These goals align well with the parent grant’s aims.

抽象的 我们对PA-20-227的回应是“对饮食中的研究的行政补充” 支持先前收集的数据我们父母赠款R01 CA119171的与饮食补充相关的分析， “营养和体育活动评估研究”。 发现并利用营养，食物和饮食模式的新颖，可靠的生物标志物，以增强领域 营养流行病学和与饮食相关的慢性疾病的理解。 实施饮食评估，双标记水（DLW）和Biospecimen收集方案（2006-- 2010年）在妇女健康计划（WHI）观察性研究（NPAAS-OS）中 在153名参与者（2011- 2014年）中进行了一项新颖的受控喂养研究，其中每个参与者都是 提供了近似她通常饮食的饮食 研究人群中的摄入量变化将被保留 NPAAS-F中的收集方案匹配NPAAS-OS。 分析斑点的养分（B-12，叶酸，α-和β-胡萝卜素，叶黄素 + Zeaxanthin，lycopha-- 3个平台通过3个平台：GC-MS，LC-MS和NMR。 还收集了68％的进气数据 补品。 收集数据。 NPAAS-FS多天食品记录中的现场饮食补充记录； NPAA参与者的饮食支持类别，使用了新的构造变量 NPAAS-FS和NPAAS-OS 用于NPAAS-FS中消耗的营养和饮食生物标志物之间的整体关联并应用 NPAAS-OS中的模型 血清和尿液代谢组学以养分为特征的食物和饮食供应中的营养素 NPAAS-FS和NPAAS-OS。 没有完全分类。 补品，多层，其他组合）可能很重要，因为我们的Kause在NPAAS-中起作用 FS表明二进制（是/否）饮食补充剂使用变量是分析的重要预测 浓度生物标志物与营养摄入量之间的关联。 目的是非常有限的。 食物 +补充剂的接触，从而增强营养生物标志物的发现，验证和 这些目标与父母赠款的AMS保持一致。