Neural circuitry of oxytocin signaling for alloparenting behavior

同种异体行为的催产素信号传导的神经回路

基本信息

批准号：
10580841
负责人：
Robert Crooks Froemke
金额：
$ 64.86万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10580841
关键词：
Acceleration Afferent Neurons Anatomy Animals Anxiety Area Auditory Auditory area Behavior Behavioral Biological Brain Caregivers Caring Cells Child Child Abuse and Neglect Child Care Child Development Child Rearing Childbirth Clinical Research Crying Cues Data Distress Educational Intervention Educational process of instructing Electrophysiology (science)Ensure Female Head Helping Behavior Home Hormones Human Hypothalamic structure Individual Infant Lactation Learning Mammals Maps Maternal Behavior Maternal Physiology Mental Health Modality Monitor Mothers Motivation Motor Mus Neuroendocrinology Neuronal Plasticity Neurons Neurosciences Neurosecretory Systems Oxytocin Pair Bond Parents Patients Population Postpartum Depression Primates Process Retrieval Sensory Signal Transduction Slice Social Behavior Social Interaction Stimulus System Testing Therapeutic Therapeutic Agents Training Training Programs Ultrasonics Visual behavioral response behavioral study biobehavior child neglect experience experimental study improved in vivo movie neglect neonate neural neural circuit neurobehavioral neuromechanism offspring optogenetics paraventricular nucleus parvocellular peptide hormone physical conditioning pup recruit response sensor sensory input social social cognition somatosensory statistics success suckling superior colliculus Corpora quadrigemina supraoptic nucleus transmission process treatment strategy vocalization

项目摘要

Project Summary Maternal care of offspring requires rapid neurobehavioral changes, including plasticity within circuits specialized for processing infant cues such as crying. Neuroendocrine signals are important for neuroplasticity, including release of the peptide hormone oxytocin. Oxytocin is released from the hypothalamus and is important for childbirth and lactation. Oxytocin also acts in the brain where it is believed to increase the salience of social information, enhancing pair bonding and maternal behavior. Clinical studies suggest that oxytocin is a promising therapeutic agent, with patients sometimes engaging more successfully in social interactions. Although there is a high rate of child maltreatment and neglect, training programs and interventions that teach parents to detect and respond to social signals have had some success. These therapies would benefit from understanding how observing, learning, and teaching behaviors required for childcare involve various neural circuits and processes, including how the central oxytocin system might be involved in neuroplasticity relevant for maternal behaviors. In this proposal, we will study the neural circuitry, plasticity, and behavioral effects of oxytocin in the context of maternal behavior and learned alloparenting in mice. We study neurobehavioral responses to infant ultrasonic vocalizations by maternal caregivers, which requires experience with pups and is facilitated by oxytocin. We will study behavioral interactions between experienced mother mice (‘dams’) and virgin females put in the homecage with dam and pups. The central hypothesis is that dams change their behavior in the presence of the virgin, recruiting them to be co-carers via behaviors that increase virgin oxytocin signaling to promote alloparenting. We will use in vivo recordings and optogenetics in behaving animals, combined with studies of neural circuits providing sensory input to hypothalamic oxytocin neurons. In Aim 1 we monitor and manipulate oxytocin signaling as virgins watch movies of dams being maternal. In Aim 2, we study how visual input and other sensory signals are routed to oxytocin neurons. Finally in Aim 3 we ask if oxytocin neurons in dams are important for changes in dam behavior to help transmit maternal behaviors or train virgins to be alloparents. In summary, here we will use behavioral experiments combined with optogenetics and in vivo recordings to ask how oxytocin is released to enable maternal recognition of infant distress calls. These experiments will provide fundamental and urgently-needed data on the neural circuitry and functional consequences of oxytocin signaling in the mammalian brain, in the context of a deep and long-standing question in neuroscience: how are specific neural circuits specialized for sensory processing and maternal behavior?

项目概要对后代的母性护理需要快速的神经行为变化，包括专门电路内的可塑性处理婴儿信号（例如哭泣）对于神经可塑性很重要。肽激素催产素的释放从下丘脑释放，对于分娩和哺乳期，催产素也会作用于大脑，据信它可以增加社会的显着性。信息，增强夫妻关系和母亲行为。临床研究表明催产素是一种很有前途的药物。代理，患者有时能够更成功地参与社交互动，尽管存在这种情况。虐待和忽视儿童的比例很高，培训计划和干预措施教会家长如何发现对社会信号做出反应已经取得了一些成功，这些疗法将受益于了解如何进行。儿童保育所需的观察、学习和教学行为涉及各种神经回路和过程，包括中枢催产素系统如何参与与母亲行为相关的神经可塑性。在本提案中，我们将研究催产素对神经回路、可塑性和行为的影响。我们研究了小鼠对母亲行为和习得异育的神经行为反应。母亲护理人员发出超声波声音，这需要与幼崽相处的经验，并由我们将研究有经验的母鼠（“母鼠”）和处女母鼠之间的行为相互作用。与母鼠和幼崽一起放在笼子里，中心假设是母鼠改变了它们在环境中的行为。处女的存在，通过增加处女催产素信号的行为招募他们成为共同照顾者我们将在行为动物中使用体内记录和光遗传学，并结合使用。为下丘脑催产素神经元提供感觉输入的神经回路的研究在目标 1 中，我们监测和研究。当处女观看母亲的电影时操纵催产素信号在目标 2 中，我们研究视觉如何影响。输入和其他感觉信号被路由到催产素神经元最后，在目标 3 中，我们询问催产素神经元是否存在。水坝对于改变水坝行为非常重要，有助于传递母性行为或训练处女成为同父异母。综上所述，这里我们将使用行为实验结合光遗传学和体内记录询问催产素如何释放以使母亲能够识别婴儿的求救信号这些实验将进行。提供有关催产素的神经回路和功能后果的基本且迫切需要的数据在神经科学中一个长期存在的深刻问题的背景下，哺乳动物大脑中的信号传导：如何专门用于感觉处理和母性行为的特定神经回路？