Neural circuitry of oxytocin signaling for alloparenting behavior

同种异体行为的催产素信号传导的神经回路

• 批准号: 10580841
• 负责人: Robert Crooks Froemke
• 金额: $ 64.86万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10580841
• 关键词: Acceleration; Afferent Neurons; Anatomy; Animals; Anxiety; Area; Auditory; Auditory area; Behavior; Behavioral; Biological; Brain; Caregivers; Caring; Cells; Child; Child Abuse and Neglect; Child Care; Child Development; Child Rearing; Childbirth; Clinical Research; Crying; Cues; Data; Distress; Educational Intervention; Educational process of instructing; Electrophysiology (science); Ensure; Female; Head; Helping Behavior; Home; Hormones; Human; Hypothalamic structure; Individual; Infant; Lactation; Learning; Mammals; Maps; Maternal Behavior; Maternal Physiology; Mental Health; Modality; Monitor; Mothers; Motivation; Motor; Mus; Neuroendocrinology; Neuronal Plasticity; Neurons; Neurosciences; Neurosecretory Systems; Oxytocin; Pair Bond; Parents; Patients; Population; Postpartum Depression; Primates; Process; Retrieval; Sensory; Signal Transduction; Slice; Social Behavior; Social Interaction; Stimulus; System; Testing; Therapeutic; Therapeutic Agents; Training; Training Programs; Ultrasonics; Visual; behavioral response; behavioral study; biobehavior; child neglect; experience; experimental study; improved; in vivo; movie; neglect; neonate; neural; neural circuit; neurobehavioral; neuromechanism; offspring; optogenetics; paraventricular nucleus; parvocellular; peptide hormone; physical conditioning; pup; recruit; response; sensor; sensory input; social; social cognition; somatosensory; statistics; success; suckling; superior colliculus Corpora quadrigemina; supraoptic nucleus; transmission process; treatment strategy; vocalization

Project Summary Maternal care of offspring requires rapid neurobehavioral changes, including plasticity within circuits specialized for processing infant cues such as crying. Neuroendocrine signals are important for neuroplasticity, including release of the peptide hormone oxytocin. Oxytocin is released from the hypothalamus and is important for childbirth and lactation. Oxytocin also acts in the brain where it is believed to increase the salience of social information, enhancing pair bonding and maternal behavior. Clinical studies suggest that oxytocin is a promising therapeutic agent, with patients sometimes engaging more successfully in social interactions. Although there is a high rate of child maltreatment and neglect, training programs and interventions that teach parents to detect and respond to social signals have had some success. These therapies would benefit from understanding how observing, learning, and teaching behaviors required for childcare involve various neural circuits and processes, including how the central oxytocin system might be involved in neuroplasticity relevant for maternal behaviors. In this proposal, we will study the neural circuitry, plasticity, and behavioral effects of oxytocin in the context of maternal behavior and learned alloparenting in mice. We study neurobehavioral responses to infant ultrasonic vocalizations by maternal caregivers, which requires experience with pups and is facilitated by oxytocin. We will study behavioral interactions between experienced mother mice (‘dams’) and virgin females put in the homecage with dam and pups. The central hypothesis is that dams change their behavior in the presence of the virgin, recruiting them to be co-carers via behaviors that increase virgin oxytocin signaling to promote alloparenting. We will use in vivo recordings and optogenetics in behaving animals, combined with studies of neural circuits providing sensory input to hypothalamic oxytocin neurons. In Aim 1 we monitor and manipulate oxytocin signaling as virgins watch movies of dams being maternal. In Aim 2, we study how visual input and other sensory signals are routed to oxytocin neurons. Finally in Aim 3 we ask if oxytocin neurons in dams are important for changes in dam behavior to help transmit maternal behaviors or train virgins to be alloparents. In summary, here we will use behavioral experiments combined with optogenetics and in vivo recordings to ask how oxytocin is released to enable maternal recognition of infant distress calls. These experiments will provide fundamental and urgently-needed data on the neural circuitry and functional consequences of oxytocin signaling in the mammalian brain, in the context of a deep and long-standing question in neuroscience: how are specific neural circuits specialized for sensory processing and maternal behavior?

项目摘要 母体护理后代需要快速的神经行为变化，包括电路内的可塑性 神经内分泌信号对于神经可塑性很重要，包括 释放胡椒马酮催产素。催产素从下丘脑释放，对 分娩和泌乳。催产素还起作用，据信它可以增加社会的显着性 信息，增强配对键和孕产妇行为。临床研究表明氧气是一种有希望的 治疗剂，患者有时会更成功地参与社交互动。虽然有 儿童虐待和忽视的高度，教师父母检测到的培训计划和干预措施 对社会信号的回应取得了一些成功。这些疗法将受益于了解如何 观察，学习和育儿所需的教学行为涉及各种神经回路和过程， 包括中央氧系统如何参与与母体行为相关的神经塑性。 在此提案中，我们将研究氧气中氧气的神经回路，可塑性和行为影响 孕产妇行为的背景和在小鼠中学习的同种异体。我们研究对婴儿的神经行为反应 孕产妇护理人员的超声波发声，需要幼崽的经验，并促进 催产素。我们将研究经验丰富的母鼠（“大坝”）和处女女性之间的行为互动 用大坝和幼崽放入寄宿家庭。中心假设是大坝改变了其行为 处女的存在，通过将原始催产素信号传导增加到的行为招募为共同职业 促进同种异体。我们将在行为动物中使用体内记录和光遗传学，并结合 对下丘脑氧气毒素神经元的感觉输入的神经元的研究。在AIM 1中，我们监视和 当处女观看大坝是母子的电影时，操纵氧加毒素的信号传导。在AIM 2中，我们研究了视觉 输入和其他感觉信号被路由到氧加毒素神经元。最后，在AIM 3中，我们询问是否在 大坝对于大坝行为的变化很重要，以帮助传播孕产妇行为或训练处女成为 同义。 总而言之，我们将使用与光遗传学和体内记录相结合的行为实验 询问如何释放催产素以使产妇对婴儿遇险呼叫的认可。这些实验会 提供有关神经回路的基本且急需的数据以及氧加毒素的功能后果 在神经科学中的深层和长期存在的问题的背景下，在哺乳动物大脑中发出信号：如何 特定的神经回路专门用于感官处理和母体行为？