Excitable Networks in Directed Cell Migration

定向细胞迁移中的兴奋网络

• 批准号: 10581845
• 负责人: Peter N Devreotes
• 金额: $ 20万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581845
• 关键词: 15 year old; Adult; Biosensor; Cells; Cellular biology; Chemotactic Factors; Development; Disease; Embryo; Event; Funding; Grant; Image; Immune response; Institution; Lead; Letters; Malignant Neoplasms; Modernization; Molecular; Neoplasm Metastasis; Normal Cell; Pathologic; Pathology; Physiological Processes; Physiology; Play; Process; Research; Role; Technology; cancer cell; cell motility; fluorescence microscope; instrument; migration; neglect; novel therapeutic intervention; wound healing

Directed cell migration is critical in development and in numerous physiological processes in the adult such as wound healing and immune response. It also plays a critical role in pathological events like cancer metastasis. Our lab has been studying cell migration for over 40 years. As a supplement to our MIRA grant, we are requesting funds to purchase a Total Internal Reflection Fluorescence Microscope with superresolution capability. As described in the research plan this instrument is essential for imaging the many biosensors we use in our studies. The instrument we have available currently is 15 years old and lacks the modern technology that would greatly facilitate our studies. We neglected to consider the need for this instrument in the original application for renewal of the MIRA. The instrument is approximately $254337. I am requesting $200000 as a supplement to my MIRA grant. The Department of Cell Biology will provide institution support of $54337 (see letter from Dr. Ewald).

定向细胞迁移对于发育和许多生理过程至关重要 成人，例如伤口愈合和免疫反应。它在病理学中也发挥着重要作用 癌症转移等事件。我们的实验室研究细胞迁移已有 40 多年的历史。作为一个 作为 MIRA 赠款的补充，我们正在申请资金购买全面内部反射 具有超分辨率能力的荧光显微镜。正如研究计划中所描述的 仪器对于我们在研究中使用的许多生物传感器的成像至关重要。仪器 我们目前可用的技术已有 15 年历史，缺乏现代技术，无法极大地 方便我们的学习。我们在最初的设计中忽略了对这个工具的需求。 MIRA 续展申请。 该仪器的价格约为 254337 美元。我要求 200000 美元作为我的补充 米拉补助金。细胞生物学系将提供 54337 美元的机构支持（参见 埃瓦尔德博士的来信）。