REASONING AND DECISION-MAKING STUDIES

推理和决策研究

• 批准号: 7719077
• 负责人: Chandan J Vaidya
• 金额: $ 4万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719077
• 关键词: Age; Attention deficit hyperactivity disorder; Behavioral; Brain; COMT gene; Catechol O-Methyltransferase; Child; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; DRD4 gene; Decision Making; Dopamine; Functional Magnetic Resonance Imaging; Funding; Genes; Genetic Polymorphism; Goals; Grant; Individual Differences; Institution; Laboratories; Pharmaceutical Preparations; Research; Research Personnel; Resources; Series; Source; System; United States National Institutes of Health; behavior measurement; brain behavior

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of this project is to examine the neuropathophysiology of reasoning and decision-making in ADHD children, its modulation by stimulant medication, and whether it varies by dopamine genes. The striatal dopaminergic system has been implicated in ADHD and we would like to investigate this further. In a series of studies with ADHD and control subjects (Ages 7-25), we will examine brain function using functional magnetic resonance imaging (fMRI) and behavioral function using laboratory experimental tasks during reasoning an decision-making. Further, we will examine whether individual differences in brain and behavior relate to polymorphism of dopaminergic genes including DAT1, DRD4, and COMT. Further, in subjects with ADHD, we will also examine whether brain and behavioral measures during reasoning and decision-making are sensitive to stimulant medication.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 该项目的主要目标是检查多动症儿童推理和决策的神经病理生理学、兴奋剂药物对其的调节，以及它是否因多巴胺基因而变化。纹状体多巴胺能系统与多动症有关，我们想进一步研究这一点。在针对 ADHD 和对照受试者（7-25 岁）的一系列研究中，我们将使用功能性磁共振成像 (fMRI) 检查大脑功能，并使用实验室实验任务在推理和决策过程中检查行为功能。此外，我们将研究大脑和行为的个体差异是否与包括 DAT1、DRD4 和 COMT 在内的多巴胺能基因的多态性有关。此外，在患有多动症的受试者中，我们还将检查推理和决策过程中的大脑和行为测量是否对刺激性药物敏感。