Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose - 2022

了解多种药物使用风险和预防药物过量的保护因素、模式和轨迹 - 2022

• 批准号: 10579709
• 负责人: Julia Elizabeth Hood
• 金额: $ 34.8万
• 依托单位: SEATTLE-KING COUNTY PUBLIC HEALTH DEPT
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2025-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10579709
• 关键词: Understanding; Polydrug; Use; Risk; Protective

Drug consumption trends in the United States have substantially changed in recent years, triggering a surge in overdose deaths. Efforts to address the crisis at the local level are oftentimes focused on meeting the needs of persons in the most advanced stages of substance use disorder (SUD), in part because this group is most visible at acute care, public health, and social service sites and corresponding data systems. Intervening at an earlier stage of use represents an opportunity to prevent drug use from progressing to polysubstance use, injection drug use (IDU), SUD, overdose, and other severe health outcomes. However, the precursors to drug use initiation and the patterns of consumption that follow are poorly characterized and the factors associated with progression to severe outcomes are largely unknown. Illicitly manufactured fentanyl (IMF) and concurrent use of opioids and stimulants are now at the core of America’s overdose crisis, responsible for much of the recent increase in overdose deaths. Specific consumption behaviors and corresponding rationale associated with IMF and co- occurring use of methamphetamine and opioids are not well-characterized and may directly correlate with overdose risk. We propose to conduct an exploratory sequential mixed methods evaluation of drug use behaviors, patterns, trajectories, and risk factors in a sample of King County, WA residents who initiated use within the past three years of a high-risk drug class (includes illicitly manufactured fentanyl, heroin, methamphetamine, cocaine, crack, and prescription opioids or benzodiazepines used for a non-prescribed or euphoric purpose). Our study will: (1) evaluate how and why polysubstance patterns emerge and evolve through one- on-one semi-structured in-depth interviews, (2) describe polydrug use trajectories following initiation of a high-risk drug class; and (3) quantitatively assess factors associated with consumption of IMF and the concurrent use of opioids and methamphetamine through a case- control study. The quantitative and qualitative results from our study will inform development of novel early intervention strategies and development of methods to reach a currently hidden population with overdose prevention programs and related evaluations.

近年来，美国的药物消费趋势发生了重大变化， 引发过量死亡的激增。解决地方危机的努力是 通常，专注于在主题最高级阶段满足人们的需求 使用障碍（SUD），部分是因为该组在急性护理，公共卫生和 社会服务网站和相应的数据系统。在使用的早期阶段介入 代表了防止吸毒进展到多物质使用的机会，注射 药物使用（IDU），SUD，用药过量和其他严重的健康结果。但是， 毒品使用启动和消费模式的特征不佳， 与进展到严重结果相关的因素在很大程度上未知。非法 现在的芬太尼（IMF）和同时使用阿片类药物和兴奋剂现在是核心 美国过量危机，导致最近过量死亡的大部分增加。 特定的消费行为以及与IMF和共同的相应基本原理 甲基苯丙胺和阿片类药物的使用未充分表征，可能直接 与过量的风险相关。我们建议进行探索性的顺序混合方法 国王样本中的药物使用行为，模式，轨迹和风险因素的评估 华盛顿州，华盛顿州居民，在过去三年的高风险毒品类别中使用 （包括非生产的芬太尼，海洛因，甲基苯丙胺，可卡因，裂缝和 处方阿片类药物或苯二氮卓类药物用于非处方或欣快目的）。我们的 研究将：（1）评估polysubstance模式如何以及为什么通过一种 一对一的半结构化深度访谈，（2）描述Polydrug使用轨迹以下 启动高风险药物类别； （3）定量评估与 IMF的消费以及通过病例同时使用阿片类药物和甲基苯丙胺 控制研究。我们研究的定量和定性结果将为发展提供信息 新颖的早期干预策略和发展目前隐藏的方法的发展 人口预防计划和相关评估。