EFFECTS OF INTERMEDIATE CYCLIC HYPOXIA ON BLOOD PRESSURE

中度循环缺氧对血压的影响

• 批准号: 7718954
• 负责人: JAMES WOODROW WEISS
• 金额: $ 0.48万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718954
• 关键词: Altitude; Blood Pressure; Blood Vessels; Cardiac Output; Cardiovascular system; Chronic; Computer Retrieval of Information on Scientific Projects Database; Disease; End Point; Equilibrium; Exposure to; Functional disorder; Funding; Grant; Hour; Hypoxia; Institution; Mediating; Metabolic; Nerve; Obstructive Sleep Apnea; Pathology; Patients; Protocols documentation; Reporting; Research; Research Personnel; Resources; Source; Testing; Trees; United States National Institutes of Health; Vasoconstrictor Agents; Vasodilator Agents; Week; day; experience; glucose metabolism; hemodynamics; relating to nervous system; respiratory; response; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypoxia experienced environmentally or as a consequence of pathology causes changes in respiratory, cardiovascular, neural and metabolic function. In patients with obstructive sleep apnea, a disease characterized by chronic hypoxia, cardiovascular and metabolic dysfunctions are reported and hypoxia has been implicated as the main factor. Cardiovascular control is mediated locally and centrally and is different along the vascular tree. This study will examine metabolic, hemodynamic and sympathetic responses normal volunteers to a 2-week exposure to nocturnal, cyclic hypoxia (altitude equivalent of 13,000 ft alternating with normoxia). We will test the effect of cyclic nocturnal hypoxia on changes in local vasodilator and vasoconstrictor balance over an entire day and over a 14 day hypoxic exposure. We hypothesize that repeated 8-hour exposures to moderate hypoxia will result in increased sympathetic nerve activity in normal volunteers but also directly decrease vascular tone. Our primary endpoint is to determine blood pressure modulation following a cyclic nocturnal exposure. Subjects will have tests of sympathetic activity, hemodynamics, cardiac output, vascular function, and glucose metabolism at baseline, after exposure, and three days following the end of exposure. Subjects will serve as their own controls and will be followed longitudinally throughout the protocol.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 环境缺氧或病理缺氧会导致呼吸、心血管、神经和代谢功能发生变化。 据报道，阻塞性睡眠呼吸暂停患者是一种以慢性缺氧、心血管和代谢功能障碍为特征的疾病，缺氧被认为是主要因素。 心血管控制是局部和中枢介导的，并且沿着血管树是不同的。 这项研究将检查正常志愿者在暴露于夜间周期性缺氧（相当于 13,000 英尺的海拔高度与正常含氧量交替）下两周的代谢、血流动力学和交感神经反应。 我们将测试周期性夜间缺氧对一整天和 14 天缺氧暴露中局部血管舒张剂和血管收缩剂平衡变化的影响。 我们假设，重复暴露于中度缺氧 8 小时会导致正常志愿者交感神经活动增加，但也会直接降低血管张力。 我们的主要终点是确定周期性夜间暴露后的血压调节。 受试者将在基线、暴露后以及暴露结束后三天进行交感神经活动、血流动力学、心输出量、血管功能和葡萄糖代谢测试。 受试者将作为他们自己的对照，并将在整个协议中纵向跟踪。