Neurobiological Markers of Rhythm: Risk and Resilience for Language Acquisition

节奏的神经生物学标记：语言习得的风险和弹性

基本信息

批准号：
10559638
负责人：
Reyna Leigh Gordon
金额：
$ 61.4万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10559638
关键词：
Academy Acquired Language Disorders Affect Area Attention Automobile Driving Behavioral Biological Biology Brain Child Clinical Data Cognition Communication Communication impairment Complex DNA Data Data Set Development Disease Dyslexia Education Expectancy Foundations Future Genes Genetic Genetic Markers Genetic Models Genetic Predisposition to Disease Genomic approach Genomics Heritability Human Impairment Internet Intervention Investigation Joints Knowledge Language Language Development Language Development Disorders Language Disorders Link Mendelian randomization Methodological Studies Methods Modeling Music National Institute on Deafness and Other Communication Disorders Neurobiology Patient Self-Report Pattern Perception Periodicity Phenotype Process Quality of life Quantitative Genetics Reporting Research Risk Risk Factors Role Sample Size Sampling Schools Series Social outcome Speech Stimulus Structure Stuttering Task Performances Testing Time Trees Vocabulary Work biobank brain pathway clinically significant comorbidity directed attention experimental study genetic architecture genetic predictors genome analysis genome wide association study improved innovation insight interdisciplinary approach laboratory experiment language impairment neural novel personalized medicine predictive modeling public health relevance repository resilience response skills social sound specific biomarkers specific language impairment success syntax theories tool trait

项目摘要

PROJECT SUMMARY. Specific Language impairment (SLI) is a common, life-long communication disorder characterized by difficulties acquiring grammar and vocabulary that affect children's quality of life, success in school, and livelihood. There is an urgent need to increase identification and treatment of children with SLI. Although SLI is known to be heritable, the underlying neurobiology of the disorder is not yet clear. Recent work by the PI has shown robust associations between rhythm and grammar traits in children, pointing to rhythm resilience as a variable involved in spoken grammar skills. Emerging evidence in the field points to co-morbid rhythm deficits and grammatical deficits in SLI, pointing to weaknesses in rhythm sensitivity as an SLI risk factor. Furthermore, rhythm and grammatical traits are both heritable, and both involve dynamically orienting attention to hierarchical structure over time, but no prior study has directly compared the genetic basis of rhythm and grammar. Here we take an understudied but promising approach to investigating potentially shared genetic architecture to rhythm deficits and SLI. Since sound patterns (across species) used to communicate are organized rhythmically, it is highly likely that present-day speech and language capacities are built on pre- existing genetic architecture for communication, which may include the rhythmic aspect of communication. Children with SLI may thus have heritable rhythm deficits that impair their ability (via common neurobiology) to process the structure of language during grammatical acquisition. The present proposal integrates new methods of genome analysis with rhythm cognition experiments aimed at understanding the mechanisms underlying the potential contribution of rhythm deficits to SLI. Aim 1 harnesses large-sample bio-repositories and extant data with Genome-Wide Association Studies (GWAS) methodology to characterize the genetic architecture of developmental language disorder. This approach allows us to construct the largest sample sizes yet for developing a genetic prediction model for SLI and to investigate the clinical significance of genes involved in SLI. Aim 2 utilizes a GWAS approach in a novel dataset to provide important new knowledge on the genetic basis of rhythm. Armed with novel knowledge about the neurobiological markers of SLI and rhythm deficits, we will then investigate a potential influence of rhythm on grammar-related traits (Aim 3a) and grammar states (Aim 3b), using an innovative selection of genomic analyses and a series of targeted laboratory experiments in children with SLI. By testing this framework of rhythm risk and resilience, these studies lay essential groundwork for multiple future avenues of improving identification and treatment of children with SLI. This project directly responds to NIDCD's call to identify genetic factors and co-occurring conditions that contribute to language impairment and to develop biomarkers of SLI. Moreover, new knowledge of the genetic basis of rhythm may also have relevance for other communication disorders that have co-morbid rhythm deficits (e.g., stuttering, dyslexia).

项目摘要。特定的语言障碍（SLI）是一种常见的终身沟通障碍特点是难以获取影响儿童生活质量的语法和词汇，成功学校和生计。迫切需要增加对SLI儿童的识别和治疗。尽管已知SLI是可遗传的，但该疾病的潜在神经生物学尚不清楚。最近的工作通过PI显示儿童节奏和语法性状之间的牢固关联，指向节奏弹性作为语法技能涉及的变量。现场的新兴证据指向合并 SLI中的节奏缺陷和语法缺陷，指出节奏灵敏度的弱点是SLI风险因素。此外，节奏和语法特征都是遗传的，都涉及动态定位随着时间的推移，注意分层结构，但没有先前的研究直接比较节奏和语法。在这里，我们采取了一种研究的但有前途的方法来调查潜在共享的节奏缺陷和SLI的遗传结构。由于声音模式（跨物种）用于交流是有节奏的现有的遗传结构用于交流，其中可能包括交流的节奏方面。因此，患有SLI的儿童可能会有遗传的节奏缺陷，这些缺陷损害了他们的能力（通过常见的神经生物学）处理语法习得期间语言的结构。目前的提案集成了新的基因组分析的方法与节奏认知实验旨在了解机制节奏缺陷对SLI的潜在贡献的基础。 AIM 1利用大样本的生物重新定位器以及具有全基因组关联研究（GWAS）方法的现有数据，以表征遗传发展语言障碍的结构。这种方法使我们能够构建最大的样本大小尚未为SLI开发遗传预测模型并研究基因的临床意义参与SLI。 AIM 2使用新颖数据集中利用GWAS方法来提供有关该方法的重要新知识节奏的遗传基础。拥有有关SLI和节奏的神经生物学标记的新知识赤字，我们将研究节奏对语法相关特征的潜在影响（AIM 3A）和语法状态（AIM 3B），使用基因组分析的创新选择和一系列目标 SLI儿童的实验室实验。通过测试这种节奏风险和弹性的框架，这些研究为改善对识别和处理的多种未来途径提供了基本基础儿童SLI。该项目直接响应了NIDCD的呼吁，以确定遗传因素和同时存在导致语言障碍并发展SLI生物标志物的条件。而且，新知识节奏的遗传基础也可能与其他沟通障碍有相关性节奏缺陷（例如，口吃，阅读障碍）。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Using neuroimaging genomics to investigate the evolution of human brain structure.

DOI：
10.1073/pnas.2200638119
发表时间：
2022-10-04
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
通讯作者：

Does rhythmic priming improve grammatical processing in Hungarian-speaking children with and without developmental language disorder?

DOI：
10.1111/desc.13112
发表时间：
2021-11
期刊：
Developmental science
影响因子：
3.7
作者：
Ladányi E;Lukács Á;Gervain J
通讯作者：
Gervain J

The relationship between cognitive control and lexical conflict resolution in developmental dyslexia.

发展性阅读障碍中认知控制与词汇冲突解决之间的关系。

DOI：
10.1080/02699206.2021.1998632
发表时间：
2022
期刊：
Clinical linguistics & phonetics
影响因子：
1.2
作者：
Dobó,D;Ladányi,E;Szőllősi,Á;Lukics,KS;Németh,K;Lukács,Á
通讯作者：
Lukács,Á

Using a polygenic score in a family design to understand genetic influences on musicality.

DOI：
10.1038/s41598-022-18703-w
发表时间：
2022-08-29
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Wesseldijk, Laura W.;Abdellaoui, Abdel;Gordon, Reyna L.;Ullen, Fredrik;Mosing, Miriam A.
通讯作者：
Mosing, Miriam A.

Processing rhythm in speech and music: Shared mechanisms and implications for developmental speech and language disorders.