AIDS AND OPIATES: A MONKEY MODEL

艾滋病和阿片类药物：猴子模型

• 批准号: 7715475
• 负责人: Shawn Patrick O'Neil
• 金额: $ 1.3万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715475
• 关键词: Acquired Immunodeficiency Syndrome; Computer Retrieval of Information on Scientific Projects Database; Dependency; Funding; Grant; HIV Infections; Institution; Macaca mulatta; Modeling; Monkeys; Morphine; Opiates; Pharmaceutical Preparations; Pilot Projects; Research; Research Personnel; Resources; Risk Factors; SIV; Saline; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. IV-drug abuse is a prominent risk factor for HIV infection and AIDS. Credible support can be found that opiates have no effect, exacerbate, or even inhibit AIDS progression. In a pilot study using the simian immunodeficiency virus (SIV) infected rhesus macaque model, we found that AIDS progression was slowed by morphine dependency. We have subsequently initiated a large trial (20 rhesus/group, morphine versus saline) to further investigate the relationship between opiate dependency and AIDS progression.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 静脉注射药物滥用是艾滋病毒感染和艾滋病的一个重要危险因素。 可靠的证据表明阿片类药物没有任何作用，不会加剧甚至抑制艾滋病的进展。 在一项使用猿猴免疫缺陷病毒（SIV）感染的恒河猴模型的初步研究中，我们发现吗啡依赖可以减缓艾滋病的进展。 我们随后启动了一项大型试验（20 只恒河猴/组，吗啡与生理盐水），以进一步研究阿片类药物依赖与艾滋病进展之间的关系。