Deficient inhibition underlies salience network hyperactivity in stress and anxiety
抑制不足是压力和焦虑中显着网络过度活跃的基础
基本信息
- 批准号:10559649
- 负责人:
- 金额:$ 18.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AdoptedAmygdaloid structureAnteriorAnxietyArousalAutomobile DrivingBiological AssayBiological MarkersBrainClinicClinicalCouplingDisease susceptibilityDisinhibitionDorsalElectroencephalographyElectrophysiology (science)EquilibriumEtiologyExhibitsExperimental DesignsFrequenciesFunctional disorderGalvanic Skin ResponseGraphHyperactivityInsula of ReilInterventionLaboratoriesLinkMaintenanceMeasuresMediatingMediationMental HealthMental disordersMethodologyModelingMoodsNeural InhibitionNeurobiologyNeurophysiology - biologic functionParietal LobePathologicPathologyPeriodicityPersonsPhysiologicalPlayPrefrontal CortexProcessResearchRestRoleSchizophreniaSignal TransductionSocietiesSourceStimulusStressanxiousautism spectrum disordercingulate cortexcognitive neurosciencecomorbiditycostfrontal lobefunctional magnetic resonance imaging/electroencephalographyinsightnetwork dysfunctionneuralneural networkneuromechanismneuropsychiatric disorderneuropsychiatrynoninvasive brain stimulationnovelnovel therapeuticsresponsesensory gatingtraittransmission process
项目摘要
ABSTRACT
Decades of research notwithstanding, there remains an urgent need to uncover the neurobiology
of stress and anxiety and develop effective biomarkers for these conditions. The salience network (SN),
a major intrinsic neural network anchored in the frontal lobe, consistently exhibits hyperactive functioning
in stress and anxiety. This SN hyperactivity has been recognized as a novel brain network pathology, but
its underlying mechanism remains elusive.
EEG alpha (8-12 Hz) oscillations, dominating intrinsic neural rhythmic activity, play a critical role in
cortical inhibition. Particularly, prevalent posterior-to-frontal (P→F) alpha projection (i.e., alpha directional
connectivity) transmits alpha inhibitory influence from the occipitoparietal cortex (a primary alpha source)
to the frontal lobe. By driving bottom-up cortical inhibition and gating sensory propagation that triggers
the SN, alpha P→F connectivity can serve to downregulate the SN. Prominently featured in
“thalamocortical dysrhythmia” or “oscillopathy” models of neuropsychiatric disorders, alpha dysrhythmia
(particularly, deficient alpha P→F connectivity) has been increasingly observed in stress and anxiety,
motivating our hypothesis that deficient alpha P→F connectivity underlies SN hyperactivity in stress and
anxiety.
Leveraging an integrative methodology of simultaneous EEG-fMRI combined with experimental
anxiety induction via stress exposure, this project (N = 140) will establish a mechanistic role of alpha
P→F hypoconnectivity in the genesis and maintenance of SN hyperactivity in stress and anxiety. This
discovery will further identify an accessible, low-cost EEG biomarker for SN hyperactivity and for stress
and anxiety in general. Finally, this discovery will isolate a new treatment target that is highly responsive
to non-invasive brain stimulation (NIBS), motivating an R01 to normalize alpha P→F connectivity as a
novel intervention for stress and anxiety.
抽象的
尽管有数十年的研究,但迫切需要揭示神经生物学
压力和动画以及为这些条件开发有效的生物标志物。显着网络(SN),
锚定在额叶中的主要固有神经元网络,始终表现出多动功能
在压力和焦虑中。这种SN多动症已被认为是一种新型的大脑网络病理学,但是
它的基本机制仍然难以捉摸。
EEG Alpha(8-12 Hz)振荡,主导内在的神经元节律活性,在
皮质抑制。特别是,普遍的后额 - frontal(P→F)alpha投影(即α定向
连通性)从枕皮层传输α抑制作用(主要的α源)
到额叶。通过推动自下而上的皮质抑制和门控感官传播触发的传播
SN,Alpha P→F连接可以下调SN。突出出现
神经精神疾病的“丘脑皮质心律失常”或“振荡性”模型
(特别是,缺乏αP→F连接)在压力和动画中越来越多地观察到
激励我们的假设,缺乏αP→F连通性是压力和
焦虑。
利用简单的EEG-FMRI结合实验的集成方法
通过压力暴露焦虑诱导,该项目(n = 140)将建立alpha的机械作用
P→F在压力和动画中SN多动症的起源和维持中的P→f次连接性。这
发现将进一步确定可访问的低成本脑电图生物标志物,用于SN多动症和压力
和动画一般。最后,这一发现将隔离一个高度响应的新治疗目标
进行非侵入性脑刺激(NIBS),激励R01将alpha p→F连接归一化
压力和动画的新颖干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wen Li其他文献
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