Historical trauma and resilience as a biological state and its association with the effects of the traditional Indigenous food chokeberry

作为一种生物状态的历史创伤和复原力及其与传统土著食物野莓的影响的关联

• 批准号: 10091062
• 负责人: Nicole Redvers
• 金额: $ 22.56万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10091062
• 关键词: Adult; Affect; American; American Indians; Anxiety; Area; Attenuated; Biological; Biological Markers; Black Chokecherry Tree; Blood Pressure; Buffaloes; Canada; Centers of Research Excellence; Chronic Disease; Collection; Communities; Complex; Consumption; Cross-Sectional Studies; Cultural Backgrounds; DNA; Data Collection; Development; Diabetes Mellitus; Dietary Intervention; Environment; Environmental Risk Factor; Epigenetic Process; Exposure to; Fatty acid glycerol esters; Food; Functional disorder; Gene Expression; Gene Mutation; Generalized Anxiety Disorder; Genes; Genetic; Glucose; Goals; Great Plains; Health; Heart Diseases; Household; Human; IL6 gene; Indigenous; Individual; Inflammatory; Institution; Interleukin-6; Juice; Lipids; Longitudinal Studies; Measures; Mediating; Medicine; Mental Depression; Mental Health; Metabolic; Metabolic Marker; Metabolism; Methylation; Modeling; Nutritional; Outcome; Outcome Measure; Participant; Patients; Phase; Physiological; Population; Post-Traumatic Stress Disorders; Prevalence; Prevention strategy; Process; Public Health; Questionnaires; Research; Research Design; Research Project Grants; Resources; Serum; Smoking; Testing; Time; Trauma; United States; abuse neglect; adverse childhood events; alcohol misuse; blood lipid; community engagement; conditioning; dietary; disparity elimination; epigenetic marker; food consumption; health data; health disparity; health equity; imprint; improved; inflammatory marker; innovation; interest; knowledge base; metabolic profile; nutrition; pediatric trauma; resilience; secondary outcome; social; tool; western diet

Project Abstract Achieving health equity and eliminating disparities has been especially slow in American Indian populations even though reducing health disparities continues to be a major goal of public health institutions. American Indian populations continue to suffer disproportionately from health problems including such nutrition-related chronic diseases as diabetes and heart disease. This research project will therefore investigate how a traditional Indigenous food called chokeberry (Aronia melanocarpa) impacts epigenetic and metabolic health in relation to resiliency markers in fifty Great Plains Indian participants. Chokeberry is an Indigenous traditional food and medicine used on its own or in mixtures of pemmican (a mixture of buffalo, fat and chokeberry) common before Western contact in certain areas of the United States and Canada. Due to chokeberry’s positive effects on human lipid and glucose measures, in addition to inflammation markers demonstrated in prior studies in non-Indigenous settings, it is worthy of further exploration in this population with very different gene and metabolic profiles. Also, the process of research with American Indian communities is significant in that it can inform best practices in community engagement orientations, approaches, and models in future research settings. Our specific aims are to explore gene expression changes that are mediated by the consumption of traditional Indigenous chokeberry in Great Plains Indians and to examine the associations between metabolic end points, epigenetics, adverse childhood experiences, and mental health with and without the consumption of chokeberry in Great Plains Indians. Our long-term aim is to increase the knowledge base on the relationships between American Indian traditional food consumption, gene expression changes and metabolic markers in relation to trauma and resilience. Our study is a mix of a cross-sectional and longitudinal study design. Baseline epigenetic, metabolic and mental health data will be collected from study participants for cross sectional analysis, with the epigenetic screen specifically repeated after the post prandial consumption of chokeberry juice to assess its effects from baseline. The epigenetic, metabolic and mental health data collection process will then be repeated after 6 weeks of the daily consumption of chokeberry juice to compare the collection variables to the previous time collections.

项目摘要 美洲印第安人实现健康公平和消除差距的速度尤其缓慢 尽管减少健康差距仍然是公共卫生机构的主要目标。 美洲印第安人人口继续遭受不成比例的健康问题，包括 因此，该研究项目将与营养相关的慢性疾病（例如糖尿病和心脏病）进行研究。 研究一种名为野樱莓 (Aronia melanocarpa) 的传统土著食物如何影响表观遗传和 五十个大平原印第安人参与者的代谢健康与恢复力标志物相关。 土著传统食品和药物单独使用或与干肉饼（水牛、脂肪的混合物）混合使用 和苦莓）在西方接触之前在美国和加拿大的某些地区很常见。 除了炎症标志物之外，苦莓对人体血脂和血糖测量也有积极影响 在之前针对非原住民环境的研究中，值得对该人群进行进一步探索 此外，与美洲印第安人的研究过程也有很大不同。 社区的重要性在于它可以为社区参与方向的最佳实践提供信息， 未来研究环境中的方法和模型。 我们的具体目标是探索传统消费介导的基因表达变化 大平原印第安人的本土苦莓并检查代谢终点之间的关联， 表观遗传学、不良童年经历以及食用和不食用的心理健康 我们的长期目标是增加大平原印第安人的知识基础。 美洲印第安人传统食物消费、基因表达变化和代谢标记之间的关系 与创伤和复原力的关系。 我们的研究结合了基线表观遗传、代谢和纵向研究设计。 将从研究参与者那里收集心理健康数据进行横断面分析，其中表观遗传 餐后饮用苦莓汁后专门重复进行筛选，以评估其效果 基线后将重复表观遗传、代谢和心理健康数据收集过程。 每天消耗苦莓汁的周数，以将收集变量与之前的时间进行比较 收藏。