HIV Vaccine Research and Development

HIV疫苗研发

基本信息

批准号：
10261698
负责人：
JULIE AKE
金额：
$ 2200万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10261698
关键词：
AIDS/HIV problem ALVAC Acquired Immunodeficiency Syndrome Acute Adult African Agonist Agreement Antigens Basic Science Blood Characteristics Clinical Clinical Research Clinical Trials Closed Cohort Studies Cohort Studies County DNA Vaccines Data Developing Countries Development Disease remission Environment Epidemic Evaluation Funding Future Germany HIV HIV Infections HIV diagnosis HIV vaccine HIV-1 HIV/STD Human Immunization Immunologics Incidence Individual International Interruption Intervention Intervention Trial Intravenous Kenya Kinetics Knowledge Laboratories Logistics Macaca mulatta Medical Research Memory B-Lymphocyte Military Personnel Monoclonal Antibody Therapy Mosaicism National Institute of Allergy and Infectious Disease Observational Study Participant Persons Phase Populations at Risk Prevalence Prevention Production Protocols documentation RNA vaccine Research Research Institute Risk Factors Safety Sampling Ships Site Specimen Handling Structure TLR7 gene TLR8 gene Thailand Therapeutic Intervention Tissues Treatment Protocols Vaccines Virus Diseases Work acute infection clinical research site cohort design and construction efficacy testing efficacy trial epidemiology study follow-up human monoclonal antibodies immunogenicity improved infrastructure development interleukin-15 receptor lymph nodes migration neutralizing monoclonal antibodies nonhuman primate operation pilot lot production pre-clinical research preclinical development programs prospective recruit repository research and development research study safety study simian human immunodeficiency virus stability testing technology development therapeutic vaccine vaccine candidate vaccine development vaccine efficacy vaccine trial virology volunteer willingness

AIDS/HIV problem ALVAC Acquired Immunodeficiency Syndrome Acute Adult African Agonist Agreement Antigens Basic Science Blood Characteristics Clinical Clinical Research Clinical Trials Closed Cohort Studies Cohort Studies County DNA Vaccines Data Developing Countries Development Disease remission Environment Epidemic Evaluation Funding Future Germany HIV HIV Infections HIV diagnosis HIV vaccine HIV-1 HIV/STD Human Immunization Immunologics Incidence Individual International Interruption Intervention Intervention Trial Intravenous Kenya Kinetics Knowledge Laboratories Logistics Macaca mulatta Medical Research Memory B-Lymphocyte Military Personnel Monoclonal Antibody Therapy Mosaicism National Institute of Allergy and Infectious Disease Observational Study Participant Persons Phase Populations at Risk Prevalence Prevention Production Protocols documentation RNA vaccine Research Research Institute Risk Factors Safety Sampling Ships Site Specimen Handling Structure TLR7 gene TLR8 gene Thailand Therapeutic Intervention Tissues Treatment Protocols Vaccines Virus Diseases Work acute infection clinical research site cohort design and construction efficacy testing efficacy trial epidemiology study follow-up human monoclonal antibodies immunogenicity improved infrastructure development interleukin-15 receptor lymph nodes migration neutralizing monoclonal antibodies nonhuman primate operation pilot lot production pre-clinical research preclinical development programs prospective recruit repository research and development research study safety study simian human immunodeficiency virus stability testing technology development therapeutic vaccine vaccine candidate vaccine development vaccine efficacy vaccine trial virology volunteer willingness

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项目摘要

The NIAID Division of AIDS and the U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research (WRAIR), U.S. Army Medical Research and Development Command (MRDC) remain committed to the common objective of developing a safe and effective vaccine for HIV/AIDS. The Agencies recognize the potential utility of an HIV/AIDS vaccine in stopping the global HIV/AIDS epidemic and the need to conduct and support basic science, preclinical development, and both vaccine and non-vaccine clinical research in developing countries where the epidemic is most prevalent. This Agreement covers the following scope of work: • design and construction of candidate HIV vaccines • pre-clinical research and development, including evaluation of candidate vaccines • pilot lot production • clinical site development including cohort characterization • phase 1-3 human clinical safety, immunogenicity, and efficacy testing • other clinical and epidemiological research studies that support HIV vaccine development

美国陆军医学研究与发展司令部（MRDC）的艾滋病艾滋病和美国军事艾滋病毒研究计划（MHRP），沃尔特·里德陆军研究所（WRAIR），仍然致力于开发安全有效的艾滋病毒/艾滋病疫苗。这些机构认识到艾滋病毒/艾滋病疫苗在阻止全球艾滋病毒/艾滋病流行中的潜在效用，以及在流行病最普遍的发展中国家进行和支持基础科学，临床前发展以及疫苗和非疫苗的临床研究的需求。本协议涵盖以下工作范围： •候选HIV疫苗的设计和建造 •临床前研究和开发，包括评估候选疫苗 •飞行员批次生产 •临床场地开发包括队列表征 •第1-3阶段人类临床安全性，免疫原性和有效性测试 •其他支持HIV疫苗发育的临床和流行病学研究