Brain Banking Core

脑库核心

基本信息

批准号：
10241893
负责人：
Edward Byung-Ha Lee
金额：
$ 105.34万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10241893
关键词：
Acute Address Adherence Alzheimer&apos s Disease Archives Autopsy Brain Brain Diseases Brain Injuries Censuses Chronic Clinical Clinical Data Communities Consensus Data Data Set Databases Diagnostic Ensure Equipment and supply inventories Evaluation Exposure to Histologic Histology Human Image Institution International Link Long-Term Survivors Military Personnel Mission Nerve Degeneration Neuraxis Neurodegenerative Disorders Office of Administrative Management Parkinson Disease Patients Prospective Studies Protocols documentation Recording of previous events Research Research Personnel Research Project Grants Research Support Resources Sampling Scanning Scotland Secure Site Slide Specimen Sports Stains Tissue Donations Tissue Sample Tissues Traumatic Brain Injury Universities brain research brain tissue central database central nervous system injury data management design digital member nervous system disorder neuropathology patient population programs repository tissue archive tissue resource

Acute Address Adherence Alzheimer&apos s Disease Archives Autopsy Brain Brain Diseases Brain Injuries Censuses Chronic Clinical Clinical Data Communities Consensus Data Data Set Databases Diagnostic Ensure Equipment and supply inventories Evaluation Exposure to Histologic Histology Human Image Institution International Link Long-Term Survivors Military Personnel Mission Nerve Degeneration Neuraxis Neurodegenerative Disorders Office of Administrative Management Parkinson Disease Patients Prospective Studies Protocols documentation Recording of previous events Research Research Personnel Research Project Grants Research Support Resources Sampling Scanning Scotland Secure Site Slide Specimen Sports Stains Tissue Donations Tissue Sample Tissues Traumatic Brain Injury Universities brain research brain tissue central database central nervous system injury data management design digital member nervous system disorder neuropathology patient population programs repository tissue archive tissue resource

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项目摘要

BRAIN BANK CORE SUMMARY Although we have made great progress in gaining a deeper understanding of traumatic brain injury (TBI) related neurodegeneration (TReND), we have not gotten to the point where appropriate thereapeutics are available. This is, in part, due to the limited number of suitable human brain tissue samples available to research institutions. In fact, there exists only one human brain tissue archive dedicated to TBI samples, located at the University of Glasgow in Scotland, UK. In order to overcome this lack of resource, the Brain Banking Core of CONNECT-TBI will bring together nine participating banks that will be capable of providing existing tissue samples from almost 2000 acute and over 800 chronic TBI cases. This Brain Banking Core will establish a unique and comprehensive central archive of all existing TBI related autopsy tissue, that will include a broad inventory of all available tissue and associated clinical data. The CONNECT-TBI Expert Consensus Group members will assess and score digitally scanned images. Within this Brain Banking Core will be high quality, robust clinical datasets and digitized histology sections that will not only support the Research Projects within this proposal, but support approved, external, researcher led studies. Furthermore, the BBC will establish a tissue donation network from all participating centers that will significantly enhance the number of available tissue samples. In all efforts, the Brain Banking Core will optimize best practice protocols and will ensure adherence to strict tissue handling, staining, and scanning protocols. Finally, the Brain Bank Core will facilitate the dissemination all TBI-related samples and data in support of the Research Projects which comprise the mission of CONNECT-TBI.

脑库核心概括尽管我们在更深入地了解创伤性脑损伤方面取得了长足进步（TBI）相关的神经变性（趋势），我们还没有到达适当的治疗方法可用的。这部分是由于可用的合适的人脑组织样品数量有限研究机构。实际上，只有一个专门用于TBI样品的人脑组织存档，位于英国苏格兰的格拉斯哥大学。为了克服缺乏资源，大脑 Connect-TBI的银行核心将汇集九家参与银行，这些银行将能够提供现有的组织样品来自近2000个急性和800多个慢性TBI病例。这个大脑银行核心将建立所有现有与TBI相关的尸检组织的独特而全面的中央档案所有可用的组织和相关临床数据的广泛清单。 Connect-TBI专家共识小组成员将评估和评分数字扫描的图像。在这个大脑银行业中，核心将很高质量，强大的临床数据集和数字化的组织学部分，不仅将支持研究项目在此提案中，但支持的外部研究人员领导了支持。此外，英国广播公司将建立来自所有参与中心的组织捐赠网络，该网络将显着提高可用的组织样品。在所有努力中，大脑银行核心将优化最佳实践协议，并将确保遵守严格的组织处理，染色和扫描方案。最后，脑库核心将促进传播所有与TBI相关的样本和数据，以支持研究项目包括连接-tbi的任务。