Brain Banking Core

脑库核心

• 批准号: 10241893
• 负责人: Edward Byung-Ha Lee
• 金额: $ 105.34万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10241893
• 关键词: Acute; Address; Adherence; Alzheimer' s Disease; Archives; Autopsy; Brain; Brain Diseases; Brain Injuries; Censuses; Chronic; Clinical; Clinical Data; Communities; Consensus; Data; Data Set; Databases; Diagnostic; Ensure; Equipment and supply inventories; Evaluation; Exposure to; Histologic; Histology; Human; Image; Institution; International; Link; Long-Term Survivors; Military Personnel; Mission; Nerve Degeneration; Neuraxis; Neurodegenerative Disorders; Office of Administrative Management; Parkinson Disease; Patients; Prospective Studies; Protocols documentation; Recording of previous events; Research; Research Personnel; Research Project Grants; Research Support; Resources; Sampling; Scanning; Scotland; Secure; Site; Slide; Specimen; Sports; Stains; Tissue Donations; Tissue Sample; Tissues; Traumatic Brain Injury; Universities; brain research; brain tissue; central database; central nervous system injury; data management; design; digital; member; nervous system disorder; neuropathology; patient population; programs; repository; tissue archive; tissue resource

BRAIN BANK CORE SUMMARY Although we have made great progress in gaining a deeper understanding of traumatic brain injury (TBI) related neurodegeneration (TReND), we have not gotten to the point where appropriate thereapeutics are available. This is, in part, due to the limited number of suitable human brain tissue samples available to research institutions. In fact, there exists only one human brain tissue archive dedicated to TBI samples, located at the University of Glasgow in Scotland, UK. In order to overcome this lack of resource, the Brain Banking Core of CONNECT-TBI will bring together nine participating banks that will be capable of providing existing tissue samples from almost 2000 acute and over 800 chronic TBI cases. This Brain Banking Core will establish a unique and comprehensive central archive of all existing TBI related autopsy tissue, that will include a broad inventory of all available tissue and associated clinical data. The CONNECT-TBI Expert Consensus Group members will assess and score digitally scanned images. Within this Brain Banking Core will be high quality, robust clinical datasets and digitized histology sections that will not only support the Research Projects within this proposal, but support approved, external, researcher led studies. Furthermore, the BBC will establish a tissue donation network from all participating centers that will significantly enhance the number of available tissue samples. In all efforts, the Brain Banking Core will optimize best practice protocols and will ensure adherence to strict tissue handling, staining, and scanning protocols. Finally, the Brain Bank Core will facilitate the dissemination all TBI-related samples and data in support of the Research Projects which comprise the mission of CONNECT-TBI.

脑库核心 概括 尽管我们在更深入地了解创伤性脑损伤（TBI）方面取得了很大进展 相关的神经退行性疾病（TReND），我们还没有达到适当的治疗方法的地步 可用的。这在一定程度上是由于可用的合适的人脑组织样本数量有限。 研究机构。事实上，只有一个专门用于 TBI 样本的人类脑组织档案库， 位于英国苏格兰格拉斯哥大学。为了克服资源缺乏的问题，大脑 CONNECT-TBI 的银行核心将汇集九家参与银行，这些银行将能够提供 现有的组织样本来自近 2000 例急性 TBI 病例和 800 多例慢性 TBI 病例。这个脑库核心将 建立所有现有 TBI 相关尸检组织的独特且全面的中央档案，其中包括 所有可用组织和相关临床数据的广泛清单。 CONNECT-TBI 专家共识 小组成员将对数字扫描图像进行评估和评分。在这个脑库核心中将会很高 高质量、强大的临床数据集和数字化组织学切片不仅支持研究项目 在此提案范围内，但支持已批准的、外部的、研究人员主导的研究。此外，BBC 将 建立一个来自所有参与中心的组织捐赠网络，这将显着增加 可用的组织样本。在所有努力中，脑库核心将优化最佳实践协议，并将 确保遵守严格的组织处理、染色和扫描方案。最后，大脑银行核心将 促进所有与 TBI 相关的样本和数据的传播，以支持研究项目 构成 CONNECT-TBI 的使命。